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PQQ and Mitochondrial bio-genesis questions?

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 Posted 11/27/2010 8:02:13 PM
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A while ago life extension had a presentation on PQQ which stated that recentresearch indicated PQQ actually allowed mitochondria to multiply.

They showed a muscle biopsy showing that after 3 months of supplementationthe muscle cells had about 20 times the mitochondria they had beforesupplementation.

What was the dosage in that lab study?

Also,doesthe nutrient get into cells with less blood supply like tendons,ligaments, and other connective tissues? Does this nutrient have thesame effect on, or is it more diminished on those tissues?

It seemsto me this is being referred to as an anti-aging nutrient to reversedegeneration caused by aging. I'm only 31, but I have degenerate softtissue conditions caused by overuse, and was wondering if their wereany studies about how PPQ could perhaps help reverse degenerativeconditions caused by other things then just aging. (Like tendinosis)

Also,I know eyes have the highest concentration of mitochondria then anyother type of cell in the body. Is it possible that a deficiency in PQQis a potential cause of sight deterioration?

Also, if 20mgs aday is good, is 30 or 40 mg/day better, or are there diminishingreturns, or a limit as to what the body can absorb and use?

Alsohave their been any longer term studies? I'm thinking that eventuallyall your cells will have as much mitochondria they're able to use, andas soon as that's reached a maintenance dose would not be any lesseffective then higher dosages.

Sorry, I have a lot of questions.I understand you might not have all the answers, but if you couldanswer what you know, and theorize about what you can that's left Iwould appreciate it. I'm really thinking about buying some, but it'skind of expensive.

Has anybody here had experiences with it?

Tracy


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 Posted 11/29/2010 2:59:36 AM
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Great questions... looking forward to any replies.  Could PQQ repair joints, cartilage, ligaments, etc.?
In my research about mitochondria, I also discovered that even though the body has ways of disposing of excess mitochondria, you can have too many mitochondria.  An over-abundance  of mitochondria can trigger cell division and muscle hypertrophy but if this happens in the airways it causes or worsens Asthma. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150970/

That article refers to an overdose of calcium influx triggering mitochondrial biogenesis; does that imply that high levels of Vitamin D would also induce mitochondrial biogenesis?

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 Posted 11/29/2010 8:02:41 AM
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Michael A Smith, MD provided the following information:

  1. The study showing the muscle biopsies was done in rats. The human equivalent dose from that study is 20 mg/day (we actually suggest 10 to 20 mg/day for general supplementation).
  2. All nutrients have limited uptake by tissues with low blood supply. If the member is looking to optimize the health of such tissues (tendons, ligaments etc...) I would suggest the upper range of the effective dose which is 40 mg/day.
  3. Again, like all nutrients and drugs, there is an effective dose. Taking more than the effective dose may decrease benefit and increase side effects. This is true for any drug or supplement. The good news is that for supplements, in most cases, they don't become dangerous but you gain no additional benefits by doing higher doses beyond the effective dose. The effective dose of PQQ is 10-40mg/day.
  4. There are no long term studies on PQQ in humans (yet!). Keep in mind that most pharmaceuticals lack long-term studies.
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 Posted 12/4/2010 4:47:20 AM
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Also quercetin shows mitochondria biogenesis:

http://ajpregu.physiology.org/cgi/content/short/296/4/R1071
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 Posted 12/9/2010 6:40:54 AM
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albedo - not trying to hijack someone else's thread here, but I read your article and had already purchased some quercetin and had some questions about it.

What do you think?

http://community.vitaminshoppe.com/n/pfx/forum.aspx?folderId=3&tsn=3&nav=messages&webtag=vs-supplements&tid=2110


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 Posted 12/9/2010 2:06:26 PM
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I have been taking pqq for nearly a month now.  I believe it has enhanced both my mental and physical function.
Will try to update after a couple more months.
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 Posted 12/9/2010 7:16:36 PM
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Interesting, but how much are you taking?

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 Posted 12/10/2010 8:17:48 AM
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Most days I take 20 mg , remainder 10 mg.  Depends on level of planned activity (workouts).
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 Posted 12/11/2010 12:08:40 PM
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spy1 (12/9/2010)
albedo - not trying to hijack someone else's thread here, but I read your article and had already purchased some quercetin and had some questions about it.

What do you think?

http://community.vitaminshoppe.com/n/pfx/forum.aspx?folderId=3&tsn=3&nav=messages&webtag=vs-supplements&tid=2110


It is a bit off topic here but I recollect this is a problem for quercetin as well as resveratrol and many other substances. There was a discussion in the old forum (here) wrt resveratrol.

The primary dietary sources of quercetin are citrus fruits, apples, onions, parsley and tea.

I do not have a scientific proof but I sometime take resveratrol and quercetin with some phosphatidylcholine (contained in lecithin) to increase absorption.

“… However,the combination of lipids and emulsifiers enhanced the absorption of quercetin significantly...”

http://www.ncbi.nlm.nih.gov/pubmed/11879062

You can look also at specific product formulations such as RevGenetics MCT

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 Posted 12/12/2010 5:05:43 AM
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albedo - Thank you.  Pete

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