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 Posted 2/13/2011 9:03:15 PM
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Just a simple question.



PQQ aids in mitochondrial biogenesis and the more mitochondria we have in each cell the greater each cells potential to create energy becomes.

If the above is true would PQQ be a useful supplement for the purpose of fat burning, particularly in older individuals (50+) irrespective of its other health benefits ?
Post #1435
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 Posted 2/26/2011 12:18:14 PM
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Dr Michael Smith any comments ?
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 Posted 3/2/2011 2:46:05 AM
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Mikee5 (2/14/2011)
Just a simple question.

PQQ aids in mitochondrial biogenesis and the more mitochondria we have in each cell the greater each cells potential to create energy becomes.

If the above is true would PQQ be a useful supplement for the purpose of fat burning, particularly in older individuals (50+) irrespective of its other health benefits ?


I think this is right.

I've been taking PQQ for 2 months and I've been able to triple the time I spend in the gym. I was about 20-25 lbs overweight, and though I've gained 5 pounds on PQQ, this seems to be all muscle, as the band of fat around my waist has diminished and my jeans are looser. The fat I do have no longer feels cool to the touch. Now it's almost as warm as muscle.

BTW: I'm 59. Eight years ago I was running and spending and hour or two in the gym every day. I was using the bottom weight on most of the Nautilus machines. But six months on Crestor almost killed me. I gained weight I couldn't lose. I stopped running. So I stopped taking this pharmaceutical poison, but the road was a long way back, and it didn't seem I'd ever get there until I began taking PQQ in December. Last week I tried Crestor again for 2 days, thinking the combination of PQQ and CoQ10 would eliminate the terrible side effects. But no, whatever the statin is doing doesn't seem related to CoQ10, as even 500 mg didn't help. 


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 Posted 3/4/2011 10:23:04 AM
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The number of mitochondria does not determine whether or not a person burns fat. With more mitochondria, you are more efficient at burning any energy source. What determines whether or not fat is used in the production of cellular energy is the availability of blood glucose and glycogen stores. Fat is less accessible for cellular metabolism as it must first be reduced from its complex form, triglyceride, to the simpler components of glycerol and free fatty acids. So although fat is a good energy depot, it's energy release is too slow for very intense activity and in order for the body to use fat, there must be a subsequent loss of sugar sources.

Michael A. Smith, MD
Clinical Information Specialist
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 Posted 4/14/2011 11:52:22 AM
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I started taking PQQ (20mg per day, 10mg in morning and 10mg at bedtime) plus 500mg of acetyl L-carnitine in the mornings. I was hoping to get an energy boost because I am so tired and pained all the time. Months later, I was diagnosed with adrenal fatigue and have discovered that I have symptoms for chronic fatigue syndrome and fibromyalgia, too.

I have had problems with high blood lipids for years. Although fish oil, red yeast rice, tocotrienols, niacin, plant sterols, etc. all seemed to help, my LDL particles were small and dense and the VAP test said I had probable metabolic syndrome plus I could not consistently get the LDL and triglycerides down to healthy level even though they had improved with the other supplements.

It looks like the PQQ and ALCAR made a huge difference in lowering my LDL cholesterol, triglycerides, and reshaping the LDL cholesterol to be larger particles that are less atherogenic.

I asked some questions about this on another site with information on PQQ, wondering if it is the PQQ or the ALCAR that is responsible or maybe they are synergistic?

The writer of the material I had read there about PQQ then wrote an article citing several studies of ALCAR showing the effects that I have observed and recommending that it be used with lipoic acid which I was already taking anyway.

http://emediahealth.com/2011/04/12/l-carnitine-helps-reduce-ldl-cholesterol-triglycerides-blood-glucose-and-insulin-in-fatty-liver-disease-and-diabetes-patients/

She speculates that the PQQ may improve the effect by boosting the number of mitochondria and thus combined with the ALCAR enabling more burning of blood fats in the mitochondria.  I also noticed about 10 pounds of weight loss while I've been using the PQQ and ALCAR, but had been thinking that was due to my really low cortisol levels from the adrenal fatigue.

I'm taking replacement cortisol now and that seems to be helping some, but it's clear from the multiple tests I had done from just before the PQQ + ALCAR to a month and a half afterwards to a couple months later that the big change in blood lipids lines up with the PQQ + ALCAR.

I have problems with low CoQ10 levels, too, for which I've had to supplement with several hundred mg per day of CoQ10 to get up to mid-range blood test results for it. So I'm going to cut out the small dosage of red yeast rice (600mg) and policosanol (10mg) I've been taking and see what happens since it seems the PQQ + ALCAR has done more than the red yeast rice did.

I'm also going to try increasing the ALCAR, too, to 2g per day because of the studies linked to from that article I mentioned above.

PQQ is still quite expensive for even 20mg per day, if it were not I might try more of that, also.


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 Posted 4/30/2011 3:34:27 AM
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Limabean thank you for your very interesting post.
I too think PQQ is expensive (on top of everything else that I take), so it is good to hear of positive results.

What else are you taking to support your health and what dose fish oils?

Kind regards
FlyingPud
Post #2386
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