IP-6 inositol hexaphosphate


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By Tom. - 6/19/2012 10:26:16 AM
To LEF ...

IP-6, has received a great deal of attention because of its immune boosting capabilities. Phytic acid, another name for IP-6, is also known for its strong mineral binding capabilities.

Tumors often cause calcium to be release from bones causing hypercalcemia.

Would taking IP-6 be wise to take in a situation where a patient has decrease appetite, high calcium, and decreased immune function?

It appears to me IP-6 would help down-regulate blood calcium while at the same time boosting immune function. How would this effect overall bone health?

Thoughts?
By DDye - 6/19/2012 12:01:44 PM
Although one study shows an inhibitory effect of IP6 on bone mineralization, the authors view it as part of a regulatory effect:   http://www.ncbi.nlm.nih.gov/pubmed?term=IP6%20bone Most research concludes that IP6 is associated with a reduction in osteoporosis. 

Life Extension's Cancer Adjuvant Therapy section recommends it: http://www.lef.org/protocols/prtcl-027d.shtml
By synesthesia - 6/20/2012 6:04:19 AM
Sorry if I'm not addressing your question properly, but I've been taking IP6 for 6 months now to chelate excess iron and I have some input you may find interesting.  I don't have a lot of knowledge regarding your specific query.  

Aside from the anti-cancer and immune supporting action of IP6 (boosting NK cells), IP6 is also effective at binding free iron (which feeds cancer, bacteria, viruses and fungals) when it is taken properly.  Aside from these benefits, it also lowers inflammatory cytokines (TNF-a)!  

IP6 should always be taken on a very empty stomach (4 to 6 hours after meals and at least 30 minutes before eating) with a full glass of water to carry IP6 through your stomach and into your intestine swiftly for proper absorption.  Any food at all present in your stomach will largely deactivate most of the benefit you might get from IP6.  Similar problems will occur if you take it without adequate water to carry it swiftly through your stomach.  Mucus, prostaglandins, acids and gastric secretions can damage IP6 if they are not diluted with water.  

When taken properly, you really only need one or possibly two 500mg doses of IP6 per day.  I typically take it first thing in the morning or just before bed, and have noticed remarkable results at rather low doses.  Regarding the dosage, I believe some are confusing IP6 with simple inositol as I have noticed some advising dosing IP6 at several grams a day, which is the standard dosage  for simple inositol supplementation.  Many cancer forums advise taking IP6 with additional inositol, and perhaps this is where the confusion occurs.  

If I take IP6 at levels higher than 500mg, twice per day (total 1000mg/day) I get dental sensitivities, which is the only side effect I've noticed from IP6.  I have never taken more than this dosage and I believe it would be unwise to do so.  Additional simple inositol may boost the effectiveness of IP6, but I have not yet tried this regime.  

I also take low dose magnesium (citrate 200mg) with lunch (at least 6 hours away from IP6), and low dose zinc (Tri-Zinc 50), also well away from when I take IP6 to reduce the possibility of a shortage of these vital minerals.  Although studies have shown as long as IP6 is not taken with meals mineral depletion does not occur, it may be wise to "cycle off" of IP6 one week per month, or 3 days per week to allow your body to replenish trace minerals which could possibly become depleted with extended use of IP6.  After 3 months continuous use of IP6, I am now  cycling briefly off of it as I describe.  

There's a very good paper on IP6: "Effect of Inositol Hexaphosphate on Lipopolysaccharide-Stimulated Release of TNF-a from Human Mononuclear Cells" which contains a great deal of valuable information on IP6.  I highly recommend giving it a look if you are interested in this remarkable supplement.  

There's an Abstract here: http://www.pjoes.com/abstracts/2008/Vol17/No02/14.html

And the Full Study here: http://www.pjoes.com/pdf/17.2/283-290.pdf

IP6 has helped me to lower excess iron (documented by blood/ferritin testing) and the resulting inflammation it had caused due to a fatty liver, and I recommend it highly.  

Stay Healthy My Friends!  
By Tom. - 6/20/2012 7:16:45 AM

Thank you for your insight and the time posting that informative reply!

I think I found my answer.. This is a very good article for all to read (hyper-text linked headline to full article):

"Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic"

[1] "... Recent studies demonstrate that this antinutrient effect of IP6 can be manifested only when large quantities of IP6 are consumed in combination with a diet poor in oligoelements ... A long-term intake of IP6 in food or in a pure form did not cause such a deficiency in humans ... Grases et al confirmed our findings and also reported that abnormal calcification was prevented in rats given IP6 ..."
_____________________________
[1] J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S.
By synesthesia - 6/20/2012 7:38:47 AM
Another great read on IP6...  A remarkable supplement!  Thanks Tom. 

I would like more information on the recommendation for taking additional simple inositol with IP6 the cancer researchers are talking about.  What's the proper ratio, and what does the additional inositol provide?  Does IP6 already include the additional inositol?  

The way they speak of IP6 as the instrument of the testing/research and then in other areas speak of IP6 "plus inositol" as though it may be the same thing is confusing!  

I've read inositol is so effective at reducing cancer risk, it has even shown remarkable results in studies with current and former smokers for reducing their risk of developing lung cancer.  

By Transpower - 6/21/2012 3:56:54 AM
Tom:  I was going to recommend IP6 Inositol for your mother, but since I have not taken it myself I didn't.  One other, more traditional, treatment you might consider for her is proton therapy.
By Tom. - 6/21/2012 8:52:36 AM
Proton therapy might be an option if it weren't for the fact her non cancerous lung tissue has sustained damage from years of smoking. Any risk to surrounding tissue could seriously compromise breathing.
By albedo - 6/30/2012 8:23:29 AM
As a side note to an interesting post (sorry I am not able to reply precisely to the questions) ...

I have been supplementing with IP6 and Inositol (in the approximate ratio 4:1 as per the CellForte formulation) for a couple of years now. Main motivation is immune system support, normal cell growth and iron chelation (*). There is some evidence also for reducing kidney stones formation (*) and cholesterol (*). Next to the good read Tom is providing, I found THIS also particularly interesting wrt slowing prostate tumor growth (*). When supplementing with IP6 I recommend also to check blood phosphorus level, I recollect evidence for higher risk of cardiovascular diseases when that is too high.

(*) conditions/concerns I have
By evermore - 9/18/2012 7:10:16 AM
here's something interesting about using it if have cancers, but i not meaning to recommend it as solo therapy:

IP6 & Inositol  4 grams on empty stomach, such as at bedtime; twice daily could be more optimal if schedulable.  An example product is “Cell Forte IP-6 & Inositol” ultra-strength powder by Enzymatic Therapy www.enzy.com .   IP6 is inositol hexaphosphate with attached calcium and magnesium, which is a rice bran extract which was found having some effects in suppressing cancers and is a weak immune stimulant.   Part of its actions is by binding up iron which cancer usually needs more of, without affecting normal cells.   IP6 may also desirably alter the expression of ‘anti-cancer’ proteins produced by the p21 and p53 genes that help control cancer growth and apoptosis. 

 I am told that Bill Sardi (The Iron Time Bomb, author) reports several reported remissions :

 “An 80-year old man with terminal liver cancer took IP6 for a few weeks prior to a scheduled rescue procedure where an anti-tumor drug was to be injected directly into the liver. A cat scan performed just prior to the procedure revealed the liver tumor was completely necrotic — the tumor was a ball of dead cells.

A middle-aged woman whose husband worked for a prominent member of Congress, who had stage 4 breast cancer, experienced a rapid and complete remission following the consumption of IP6.

At age 70, a man was diagnosed with lung cancer. Radiologists had missed a lung tumor the size of a golf ball in an earlier x-ray. A year later it was the size of a softball. Chemotherapy reduced the tumor by 75 percent. In 1999 the man began taking IP6. By 2004 the lung tumor had completely disappeared, which was confirmed by bronchoscopy and x-ray.

A man with recurrent bladder tumors submitted to surgical removal in 1999, 2000 and 2001. He then embarked upon the use of IP6 as a dietary supplement and has not experienced a return of bladder tumors in 38 months.”

... however, what is not known is its frequency of actually causing cancers to "disappear" ... perhaps not often...

 .... and nothing said in these above briefs of cancer cases of what else the cancer patient could have took or did  (Budwig's diet, stop sugar intake, change cooking methods, took medicinal mushrooms or other beta glucans, exercise, curcumin, DIM (or more cruciferous veggies),.. or what?)

  want a non-chemo drug which may suppress cancer growth at least in a melanoma patient?   then research  drug disulfiram (Antabuse)  250mg or 500mg daily ... but this causes alcohol intake to be very nauseaous and would have to build up a tolerance to 500mg even without drinking alcohol .. zinc 150mg daily slightly improves its anti cancer results.

 (“Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease” Mol Cancer Ther 2004;3:1049-1060.) 

N-acetyl-L-cysteine supplementing would likely decrease the anti-cancer effectiveness of disulfiram by decreasing ROS ( “Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma” BW Morrison, etal, Melanoma Res., 2010 Feb;20(1):11-20.)

By New Moon - 2/22/2013 7:08:33 PM

Hi Everyone ,

Just my thoughts on this IP6 is getting more positive by theday not going into too much detail I am 50ish I have  Hemochromatosis  and been on a downward spiral for some time now Joint pain, stomach pain thirsty all the time fatigued for about 3 years till I decided to get myself to the Docs not been there for around 5 years I have hep c also due to some stupid things we do when we are young, Im now just gone 50 and paying for it, drank lots partied hard paying for it so now I have to fix it , had blood tests done not  looking good,,,

 

Ferritin- 2537 ug/l     Range   30-500

Iron- 46.9 umol/l          "      5.0-30.0

Platelets- 77                  "       150-450

GGT- 152 u/l                   "       5-50

AST- 256 u/l                    "       10-40

ALT- 327 u/l                    "       5-40

 

Now to me looking at this it is not good had to have blood lettingdone for 2 months but really didn't like it, so looking around the web found IP6 lots of research later decided to get it, found Puritins Pride IP-6 Inositol Hexaphosphate 5 x 510 mg 120 caps around $60AU with shipping well I have started a diary as well just to keep track of my progress, well and I have to say I am amazed at how I am feeling even after a few days just my inner spark of energy alertness Just an overall feeling really good above all I am even feeling horny again some may laugh but due to my symptoms I have had no libido for a long time so to me this is a miracle!,have been taking 2 caps 1.2 grams morning and night on an empty stomach and will continue to do use this I do believe in it, I will get blood tests done againin 3 months and see if there is any change, will post results  Thanks IP-6 you are a Miracle. BigGrin 

By DDye - 2/24/2013 4:26:55 PM
Welcome to the Forums, New Moon.

D Dye
Moderator
By trevvb - 7/17/2013 6:56:41 AM
Hi , i am very interested in the use of IP6 (inositol hexaphosphate) as a precaution to high blood iron levels (hemochromatosis).
I was tested with 400mg/l iron in my blood some 12 years ago which was on the high side (i am 55yo now).
There is anecdotal evidence that my grand father died of multi organ collapse due to this condition so i may have an inherited condition (but he was in his 90,s so it may not have been)
I much prefer this technique to phlebotomy as i have a natural aversion to the sight of blood.
This treatment is relatively untested but anecdotal evidence suggests it is effective.
I am therefore very grateful to the posters "synesthesia" and "new moon" on this string for posting their experiences with taking IP6 + Inositol. I am about to start taking it as well and would be very interested in discussing their results to date as things progress - and linking in with any others who are thinking of this precautionary treatment.
Thanks all.
By DDye - 7/17/2013 7:05:47 AM
Welcome to the Forums, trevvb.

D Dye
Moderator
By synesthesia - 7/17/2013 12:17:03 PM
Hi trevvb, & welcome!  

I developed high iron from being a male in a world where  food is "fortified" with iron to combat epidemic anemia in menstruating females. Problem is, men tend to accumulate excess iron as they age and having to eat iron fortified foods every day doesn't help.  Man evolved in a world where dietary red meat was relatively rare and intestinal worms relieved us of any excess iron.  Now the worms are gone and red meat is a dietary staple, in addition to iron fortification of all flour, cereals, etc.  

Doctors and laboratories have set the "normal" limits for stored iron (ferritin) at remarkably elevated levels for men (300, 400 or more) not because these levels are healthy, but because elevated iron is so common in modern man.  The Iron Disorders Institute provides a far more informative picture of the difference between the normal accepted range for ferritin, and what optimal levels of ferritin are for healthy iron homeostasis.  Look Here:

 http://www.irondisorders.org/iron-tests/  

Under Serum Ferritin (SF)

"Serum ferritin measurements range from about 15–200 ng/ml for women and 20–300 ng/ml for men.  Although laboratory ranges vary, most are close to these values.  Approximately 95% of the population will fall within “normal” population range simply because ranges are calculated using standard statistical methodology.  Except for the lower ends of these ranges, which can predict anemia or iron deficiency anemia, the ranges per se do not define optimal or even healthy iron levels."

"Optimal SF (Serum Ferritin) ranges for men and women are 25 – 75 ng/ml" (emphasis mine)

-----------------------------------------------

I understand blood donation is not for everyone, and I'm amazed at the number who do donate regularly.  I'm in the medical profession (a technician) so I didn't have major issues with it.  I started on IP6 after I found I had elevated stored iron (ferritin around 200) and found the blood bank would only take me every 8 weeks.  As each donation reduces ferritin by about 30 points, this would have taken nearly a year for me to reach my target of ferritin/50, as iron rebounds to a certain extent between donations.  

I found IP6 really accelerated my "de-ironing" process, as when combined (blood donation and IP6), I easily overshot my target and wound up with ferritin in the teens after only a few months on IP6 and 3 blood donations.  Interestingly, when I took a break from donating and IP6, my ferritin quickly rebounded up towards 100 again in just a few months time.  I believe this is due to the fact that although some iron is stored in the blood as ferritin, much more is stored in the liver which is the primary storage site for waste/excess iron.  Once blood levels are drawn down, iron starts moving from the liver to the blood, and this results in the quick rebound in blood ferritin.  This takes a great load off your liver, but means truly de-ironing your entire body takes time to extract excess iron from storage tissues like the liver.  

After another few months of more careful de-ironing, cycling off IP6 for a month after blood donation and donating less frequently, my ferritin has stabilized right around the sweet spot of 50.  I look and feel younger!  My insulin reactivity is better and I don't get shaky and weak if I skip breakfast anymore.  My ruddy reddened face and neckline have lightened, and my hair is even fuller with less gray around the temples (high iron displaces copper and copper is what gives hair its color).  I feel as though I've found the fountain of youth!  

I never took more than 2, 500mg (total 1000mg/day) of IP6 per day...  When I tried this (taking more) I developed dental sensitivities, and once my iron got really low, my tongue would even get sore (a sign of anemia).  I'm now down to just one IP6, 3 times a week maintenance and no longer need to donate blood.  The trick with having IP6 work effectively is to take it only on a very empty stomach with a full glass of water.  If taken with food, or within 3 to 4 hours after meals, IP6 will simply strip minerals (including some important ones, like zinc/magnesium) out of the meal and become too loaded up with desirable minerals to chelate much iron from blood plasma.  I also supplemented some low dose zinc and mag citrate (taken with my mid-day meal, well away from the IP6)  to insure I wasn't chelating too much zinc or magnesium.  

First thing in the morning worked well for me, 30 minutes before breakfast; and last thing before bed if taking 2 per day.  I experienced no side effects at all other than the above mentioned dental sensitivities when taking too much, and the sore tongue when I briefly became anemic from donating blood and taking IP6 at the same time.  IP6 was very easy on my stomach and I had no problems taking it first thing in the morning.  

The (stand alone) ferritin blood test is quite cheap and your doc shouldn't mind ordering this for you every few months to monitor your results.  You don't even need to be fasting for the stand alone ferritin test.  Life Extension also offers a stand alone ferritin test at a very reasonable cost in their blood lab catalog.  Bottom line...  Ferritin (stored iron) into triple digits may look "normal" in the reference ranges of your lab report, but it is not "OPTIMAL" for best health.  Best to keep it in double digits for a long life with good health!  

Good Luck, and let us know about your experiences.  
By synesthesia - 7/17/2013 1:23:38 PM
I wanted to mention...  Curcumin and Querceitn are also both known iron chelators and tea (green and black) as well as coffee block absorption of dietary iron.  Some believe this may be one clue to their mysterious antioxidant, anti-cancer and beneficial properties.  

Anything in the diet that helps control excess iron seems to be associated with good health.  One study even showed the longevity benefit of Calorie Restriction CR/diets could be mimicked (in fruit flies) simply by feeding a normal, though iron restricted diet.  It may turn out we don't need to starve ourselves to gain the potential extended longevity of CR diets...  Just control iron!  

Also...  Vitamin-C, when taken with meals, GREATLY increases iron absorption from the meal/C combination, so I now consider vitamin-C an "empty stomach" supplement.  

Stay Healthy My Friends!  
By trevvb - 8/2/2013 6:38:02 AM
Hi again,

Thanks for those great two posts synesthesia  -  you are a very well informed person and your "real" experiences with taking IP6 are invaluable.
Well i will keep this short apart from to say that my IP6 arrived yesterday and i took my first one today. (before breakfast on an empty stomach with a glass of water).
I am lucky in the fact that i have no symptoms of high blood iron levels  -  so am not likely to notice any preceived change through taking the tablets.
However my previous real results of high iron and my hereditory potential (see previous post) strongly suggest my current iron levels are going to be high.
Thus taking these tablets will i know be doing something positive and will give me a certain amount of "feelgood" factor.
I am planning to only take one tablet (500mg) a day for five days a week based on your comments and from others on other websites.
This is because i believe my iron level is not acutely high , and i do not want to overdose with the result of iron and other mineral levels getting too low.
This is more about maintaining a healthy balanced level - even though i am not actually measuring it.
I will check in every now and then and update on any experiences i notice (or not as the case may be) - but also to update on your progress and that of any others who message in.
Once again thanks for all your advice and knowledge sharing.
This old "internet communication" potential can really be a great thing cant it !

"Live long , prosper and stay healthy"
By albedo - 8/2/2013 8:30:02 AM
With reference to my previous post in this thread and my most recent blood tests results, the iron and ferritine have normalized. I am happy about this. There is a good chance this is due to the IP6 but there are confounding factors due to other iron chelators such as green tea (I am drinking it and supplementing with the extract from LEF). Also, if you look at those results, phosphorous remained normal which I am happy with.

Hence, overall I am happy with IP6.

As the composition of the formula I am taking is the following ...



... I just wonder if someone has experience with impact (if any) on calcium levels. In my last results Ca is a bit on the high end, despite in the normal range and similar to my past years values, so I am not worried.
By Transpower - 8/2/2013 3:46:07 PM
I take 4 grams of (regular) inositol each day, in divided doses.  It keeps me calm and focused on my work.  I asked my orthomolecular physician about IP6--and his response was that it's "too early to tell" if one should take it.  The Web has some articles about how it seems to "cure" cancer.  Let us know how IP6 works for you.
By albedo - 3/28/2014 1:23:43 AM
Regarding IP6 you might check out Bill Sardi's page:

http://www.longevinex.com/articles/a-unifying-theory-of-aging-part-3/

where he also writes about role and control of iron in aging.
By Transpower - 3/28/2014 6:00:17 AM
Albedo:  Are you now taking Inositol IP6?
By albedo - 3/29/2014 2:54:55 AM
Trans, I am taking THIS.
By DDye - 4/1/2014 7:39:52 AM
Welcome to the Forums, FB.

D Dye
Moderator
By Funnybone - 4/1/2014 8:10:32 AM

Hello!

Not sure if this is the right place to message you about this, I did try your pm but it doesn’t work for me.

Could you please shed some light? I have recently discovered I have too much iron and wanted to know more about how to use IP6.Do you know how much iron is being removed and by what dosage? An average, less than, more than? 

I’ve been taking IP6 (Inositol hexaphospateand inositol 1,020 mg mixed with 100 mg calcium, 145 mg phosphorus, and 30 mg magnesium, which are part of the supplement) to help with the oxidation process,but never realised it could remove iron from the blood. Do you think this is a good combination and could you tell me what you are using please?

Also, I would be interested to know what other supplements and antioxidants help with too much iron, would it be ok for you to make some suggestions? I’m new this problem and am finding that there’s a great deal to understand. 

I have also been taking 500 mg vitamin Cwhen (if) I wake up in the middle of the night, initially to help boost my immune system, but then realised it chealates iron. I have started researching to understand if this is a good idea or not when I found your post. Do you know if it’s safe to take vitamin c in this way? I thought it might be ok as it’s so far away from food, but not sure if there are other reasons I shouldn’t betaking it (apart from helping to absorb more iron from food).

Any help you can give me is very much appreciated.

By fastingly - 4/1/2014 8:49:42 AM
Funnybone, from everything I've read and understand, vitamin C is a factor with iron absorption in the gut.
Alcohol is another thing that increases iron absorption in the gut.
For healthy people, absorption is probably the biggest issue when it comes to iron,  because typical diets contain at least 20 times the amount of iron your body actually needs, but so very little of it actually gets absorbed.  Some experts suggest eating less meat, less alcohol, and less vitamin C when iron stores are excessive.

The body more readily absorbs iron from meat than plant sources (many plant food stuffs also contain a bit of IP6 which blocks some mineral absorption --but that is  another matter entirely, since most advocating IP6 around here suggest taking it separate from an actual meal).
When I found-out that my blood was too high in iron about ten years ago, I immediately ceased iron-fortified foods and stopped with all supplements containing iron, switched to a more plant-based diet, then I dutifully started donating blood every chance the blood bank allowed me to do it, it took about 4 or 5 years of this to achieve healthy ferritin levels.
Right now, my body is in the fortunate state of having optimized ferritin iron levels hovering just barely below 50ng/mL, but this comes with a new burden of needing to be careful about iron stores in the other direction. The danger of anemia comes into play at levels below about 20 ng/mL, but long before that there are negative side-effects of going below 50 ng/mL: the worst is that you are actually making your cardiovascular system less efficient by not having adequate iron, but more noticeably is that some forms of hair loss can be a possible side-effect.
http://www.webmd.com/skin-problems-and-treatments/hair-loss/news/20060516/hair-loss-may-be-iron-deficiency
By synesthesia - 4/1/2014 6:07:30 PM
Hi Funnybone, & welcome!  You've come to the right place.

Congratulations on discovering your iron elevation...  Doctors don't routinely test for this and many are oblivious to the dangers they face from chronically elevated iron.  

IP6 supplements often state they "contain" calcium, phosphorous and magnesium, because these minerals are bound-up by IP6 to provide these minerals for the seedling.  Humans are not supposed to be able to break down the IP6 to provide these minerals in a usable form, and in fact, IP6 will attract and bind additional (but trivial) amounts of these minerals in human plasma.  If additional free minerals are actually added to the IP6 supplement, the IP6 will quickly get loaded up with these added minerals and won't chelate too much iron.  

IP6, when taken alone on an empty stomach quickly enters the body intact and binds free/serum iron in blood plasma, but does not affect iron bound to proteins like hemoglobin or ferritin.  Never take IP6 with food, as it will bind important dietary minerals in the gut, but will get too loaded up with these to pick up free iron in blood plasma.

When plasma iron falls, due to ingestion of IP6, the body will break down ferritin (stored iron) to keep up with demand for iron to build red blood cells and over time, stored iron/ferritin should also fall.  

A single blood donation will remove more iron than IP6 will chelate over several months, but be warned...  The needle they use at the blood bank is a BIG one!  About the size of a pencil lead.  It has to be, or it would take forever to drain off a pint.  If you do donate blood, donate only "whole blood".  Not plasma or platelets.  The iron is in the red blood cells!  Good hydration is the key to a happy donation experience.  Never go to the blood bank in the morning (when most are fairly dehydrated), but a couple of hours after lunch.  Drink water within the hour before you donate, and afterwords in the canteen before you leave.  

Vitamin-C will increase iron absorption from dietary sources if taken with meals...  Vitamin-C taken on an empty stomach is a good thing though!  Drinking Tea and Coffee with meals will reduce absorption of dietary iron...  Also a good thing!  

Virtually all breakfast cereals are HIGHLY fortified with iron, and often contain vitamin-C too, so folks with high iron should simply avoid these iron bombs.  Liver is also very high in iron and is something to avoid.  

I believe in "cycling" IP6 to be certain I'm not over-chelating important minerals like zinc.  I usually take it Monday/Wednesday/Friday for a month, and then take a week off to let trace minerals stabilize.  Chelation is not something you want to do fast, but is best done slowly.  If you take pure IP6 properly (on an empty stomach with a full glass of plain water), you WILL get results, and both serum and ferritin iron should fall.  

Happy to blab on about this if you have any other questions.  There's a great site on iron called Health-e-Iron here:
http://www.healtheiron.com/
Almost too much information, but once you start reading, it quickly becomes quite fascinating.  

Get that iron lowered by hook or by crook...  No big rush, but you'll feel better and enjoy better health when you do!