Joint pain caused by resveratrol?


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By lemmor - 10/21/2011 7:52:00 AM
I would want to hear from someone in this forum who suffers joint pains while taking resveratrol. In my case, 8 months ago I was very active playing tennis and run 20 minutes on the treadmill without feeling pain in my knee joints and ankle.

But now, I can't play tennis anymore because of the lingering pain in my left knee.I run less that 10 minutes last week and my ankle started to ache. I am very worried because I'm a very active person and I'm afraid I may not be able to do my usual exercise or even go to the gym.

Is it a possible side effect of resveratrol? I only take 75mg resveratrol with 90mg quercetin. I had never experienced such knee pain before taking resveratrol.
By MrGeorge - 10/22/2011 6:02:30 PM
What other nutrients are you taking?

It could be a coincidence also.

You can search "resveratrol joint pain". There's others with this problem.

http://immortalhair.forumandco.com/t1177-resveratrol-joint-pain
By COQ10 - 10/23/2011 6:16:28 PM
Albedo,

We now have Krill oil for inflammation!!!

r
By LouD - 10/24/2011 6:39:49 AM
There may be something to this. I've had knee pain for months now, and after eliminating resveratrol for 48 hours, the pain was cut in half.
By lemmor - 10/27/2011 9:35:52 AM
Thanks for the info, Tom. I already stopped taking resveratrol. I'm taking glucosamine with MSM for joint nourishment and hoping for some improvements on my knee pain in the coming weeks.
By Rob9737 - 10/27/2011 11:44:05 AM
I developed the worst case of tennis elbow of my life while taking 250mg of resveratrol, but I have no way to prove that it is what caused my problem, though I was alway suspicious that it was the culprit.  There are quite a few anecdotal accounts in chat rooms, for whatever they are worth, of people developing tendinitis while taking resveratrol.  But without well-designed studies there really is no way to tell.  Cheers!
By LouD - 10/27/2011 1:01:58 PM
I've been taking 200 mg or so daily for several years, but only noticed a problem several months ago. I was also not taking a mineral supplement with copper.

Mega-doses May Induce Side Effects

"Once mega-doses of resveratrol (more than 500 mg) began to be employed, side effects like anemia, Achilles heel tendonitis, anxiety reactions, numbness in the fingers, began to be reported," says Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), a leading brand resveratrol dietary supplement." This is probably because resveratrol is a copper chelator and excessive chelation will impair the availability of copper which is needed for collagen formation and nerve regeneration," he says. "Resveratrol is relatively safe, but not absolutely safe at any dosage. There are drawbacks," he adds.

Some online suppliers of resveratrol pills, who have no medical training, irresponsibly recommend up to 7000 milligrams of resveratrol a day. There is also evidence that supra-high dose resveratrol inhibits the absorption of folic acid (vitamin B9), an essential nutrient needed for DNA repair. [European JournalNutrition 46: 329-36, 2007] High doses have not been tested in humans for long-term use.

By charmed - 10/27/2011 6:57:05 PM
Is the source of the resveratrol a variable? Knotweed vs muscadine grapes?
By charmed - 10/28/2011 12:47:28 PM
I have read that some people have gastric problems with knotweed and wondered if all the cases of joint pain happened to people taking that source of resveratrol.  I take Neocell resveratrol, which is only sourced from grapes.
By LouD - 10/31/2011 3:35:03 AM
DDye (10/28/2011)
Yes.  Life Extension's resveratrol contains trans-resveratrol from Polygonum cuspidatum extract (root) and whole red grape (Vitis vinifera) extract.


I was most recently taking the NOW Foods resveratrol, which, according to its label, is derived from the same sources as the LEF resveratrol. After stopping it for 2 days, my knee pain was reduced by about half, and after a week of abstinence, overall aches and pains are down by about two thirds. My knees, which had seemed swollen, have now returned to normal, and this morning I was able to do a deep knee bend for the first time in more than a year.
By APMLARA - 11/9/2011 1:18:35 PM
Hello. I'm new here and I didn't like the fact that the use of resveratrol can cause anemia as a side effect. Is that real? Or only coincidence? I'm taking trans resveratrol- 400mg per day - for almost 6 months. My parents are also taking the same amount too and none of us have experienced anything wrong at all until now. But why it would cause anemia?? I would like to understand how it happens. The fisiology behind it. If someone could give any information, I'd apreciate a lot. Thank you. Ana 
By LouD - 11/10/2011 2:01:54 AM
APMLARA (11/9/2011)
Hello. I'm new here and I didn't like the fact that the use of resveratrol can cause anemia as a side effect. Is that real? Or only coincidence? I'm taking trans resveratrol- 400mg per day - for almost 6 months. My parents are also taking the same amount too and none of us have experienced anything wrong at all until now. But why it would cause anemia?? I would like to understand how it happens. The fisiology behind it. If someone could give any information, I'd apreciate a lot. Thank you. Ana 


Even grape juice can cause a problem:

"The same antioxidant compounds in dark grape juice that are noted for their health benefits in fighting heart disease may have a downside, according to new research in the Journal of Agricultural and Food Chemistry. In cell studies, scientists with the U.S. Department of Agriculture and Cornell University found that polyphenols in purple (also called red) grape juice can inhibit the uptake of iron, which could increase the risk of iron-deficiency anemia...

"Dark grape juice reduced iron availability by 67 percent, while prune juice produced a 31 percent reduction. Light-colored juices, on the other hand, actually had the opposite effect; they increased iron uptake. Pear juice produced the highest uptake levels, followed by apple, orange, grapefruit and white grape juices."

http://www.sciencedaily.com/releases/2002/12/021213062321.htm

So it might be wise to take resveratrol and a multi-mineral supplement on alternate days. And if you've had a problem with anemia, you might want to avoid formulations with quercetin, which is an iron chelator and is in the LEF capsule formulations.

If you look at the Longevinex brand formulation, you'll see this, in part:

Quercetin: Iron chelator

Resveratrol: Copper chelator, controls iron via hemeoxygenase . . .

Rice Bran Phytate: Iron, copper chelator. Anti-calcifying agent.




By MrGeorge - 11/12/2011 3:16:02 PM
Lately I've been on a sulfur kick and have run into sulfur's effect on healthy joints. Perhaps the resveratrol is depleting sulfur levels in some way. Could be it prevents it from being absorbed properly or chelates it. Could be that it is directed somewhere else and away from the joints.

Noticing that some have joint problems and many have alleviated those problems to some degree with MSM it might be worth looking at.
By - 12/30/2011 6:59:11 PM
Is it possible that your pain is from the quercetin.  Every time I take a product that has quercetin in it I have joint pain.  I have taken a product and did not know quercetin was in the product and when the joint pains started I would look closely only to find that quercetin was was on the ingredients.  You can buy resveratrol without quercetin but you have to look closely.  Try it without quercetin and see if the joint pains go away.
By LouD - 1/7/2012 3:11:56 AM
lloyd (12/30/2011)
Is it possible that your pain is from the quercetin.  Every time I take a product that has quercetin in it I have joint pain.  I have taken a product and did not know quercetin was in the product and when the joint pains started I would look closely only to find that quercetin was was on the ingredients.  You can buy resveratrol without quercetin but you have to look closely.  Try it without quercetin and see if the joint pains go away.



Mine wasn't. I still take quercetin nearly every day, but I've cut out reservatrol completely. It's too dangerous, in my opinion.
By charmed - 2/21/2012 7:11:29 AM
A new study showing cancer benefits for muscadine based resveratrol (like NeoCell)

http://www.sciencedaily.com/releases/2012/01/120127140939.htm
By LouD - 3/19/2012 9:36:19 AM
charmed (2/21/2012)
A new study showing cancer benefits for muscadine based resveratrol (like NeoCell)

http://www.sciencedaily.com/releases/2012/01/120127140939.htm


And the researcher says, "It depends in large part on a healthy cell's ability to wait out damage," which is less than encouraging for people taking this for years without a break.
By limpy - 8/17/2013 2:11:40 PM
I'm 78, have Arthritis on my right knee and have been taking 500Mg of Trans-Resveratrol for years-I have tried different supplements for my joint pain-I was also using a frozen gel pack on that knee every night for about 45 minutes-About 10 months ago, I started taking the LEF Bio-Collagen with Patented UC-II and my pain does not bother me anymore-I exercise for 50 min 6 days a week dancing heavy metal rock and feel no pain-Before I could not sleep on my right side because my knee started to hurt, now days it does not bother me-I only take one pill a day and will keep taking them-

Best regards and stay healthy 
By Sameer - 9/15/2013 10:18:44 PM
Yes i think you are right as you have been taking this pill from quiet some time with out any side effects, so it is not matter to be bothered!!
By MachineGhost - 9/17/2013 11:12:52 PM
I've taken 250mg of trans-resveratrol (50% knotweed) for a decade now.  In that time I've had the cartilage on my right jaw joint completely disappear and my first fingers and big toes are curving inwards.  All of my joints now crack when moving, whereas only my right shoulder (mouse arm) did before.  There is no pain.  Since the latter got worse during the second half of last year during the time when I [re]added pterostilbene, quercetin, curcumin and UC-II and increased the weights, it is clear there is something going on with these bioagents.  The cracking spread while taking the UC-II which I stopped early.  I've dropped trans-resveratrol and curcumin a month ago and pterostilbene followed suit this week as I've seen no improvement.

Resveratrol/pterostilbene could deplete too much estrogen, however my estradial was 10% above the optimal range, unless it depletes the other estrogens that weren't checked?  Knotweed is chemically similar to quinolone which can cause joint destruction.  Curcumin inhibits mTOR which is critically necessary for muscle growth to occur and very likely growth of other tissues.  UC-II I now consider to be a bad idea; it is teaching your immune system what to recognize in minute quantities so it could potentially cause an autoimmune problem which wasn't even there to begin with.  I almost feel like suing the manufacturer of UC-II if it would be worth it.

And the kicker is I cannot even tolerate even 1 gram of MSM, at least all at once, without getting painful headaches, nevermind a whole tablespoon.  So it looks like I'll be going back to the Doctor's Best Glucosamine/Chondroitin/MSM (and avocado unsaponifiables now and then) as I was when regenerating the cartilage on my jaw.  Insurance only provides credit for an overpriced, low-dose version (21st Century) in their OTC Medicare pharmacy that doesn't even last the requisite number of months. Doze
By MachineGhost - 9/19/2013 7:11:46 AM
Came across the below when checking out strontium [emphasis added]:

According to the manufacturer, strontium ranelate should be taken 2 hours apart from food, milk and derivative products, and medicinal products containing calcium. Should be taken 2 hours before antacids. Treatment should be suspended while taking oral tetracycline and quinolone antibiotics, as these chelate the strontium ion.
By DDye - 10/27/2011 9:41:57 AM
Please report your results.  My own regimen has included resveratrol for years with no evident adverse effects. 
By DDye - 10/28/2011 4:03:18 AM
Yes.  Life Extension's resveratrol contains trans-resveratrol from Polygonum cuspidatum extract (root) and whole red grape (Vitis vinifera) extract.
By DDye - 11/10/2011 4:27:04 AM
A modest reduction in iron levels could be a good thing according to the studies referenced below. In answer to AMPLARA, am not aware of any studies that have demonstrated that resveratrol causes anemia in its users.  If it can have this effect as noted in an earlier post, it's not common.

One study http://www.ncbi.nlm.nih.gov/pubmed/19409912 even concludes, "Resveratrol is a potent inhibitor of suicidal erythrocyte death during energy depletion, oxidative stress and isoosmotic cell shrinkage. The nutrient could thus counteract anemia and impairment of microcirculation under conditions with excessive eryptosis."

Yearly or twice yearly blood testing will uncover anemia if one is concerned about the possibility.  Resveratrol is consumed by me daily and my iron level has been normal, even with a vegetarian diet.

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2. Wells BJ, Mainous AG 3rd, King DE, Gill JM, Carek PJ, Geesey ME. The combined effect of transferrin saturation and low density lipoprotein on mortality. Fam Med. 2004 May;36(5):324-9.

3. Klipstein-Grobusch K, Grobbee DE, den Breeijen JH, Boeing H, Hofman A, Witteman JC. Dietary iron and risk of myocardial infarction in the Rotterdam Study. Am J Epidemiol. 1999 Mar 1;149(5):421-8

4. van der A DL, Peeters PH, Grobbee DE, Marx JJ, van der Schouw YT. Dietary haem iron and coronary heart disease in women. Eur Heart J. 2005 Feb;26(3):257-62.

5. Tuomainen TP, Punnonen K, Nyyssönen K, Salonen JT. Association between body iron stores and the risk of acute myocardial infarction in men. Circulation. 1998 Apr 21;97(15):1461-6.

6. Tzonou A, Lagiou P, Trichopoulou A, Tsoutsos V, Trichopoulos D. Dietary iron and coronary heart disease risk: a study from Greece. Am J Epidemiol. 1998 Jan 15;147(2):161-6.

7. Alissa EM, Ahmed WH, Al-Ama N, Ferns GA. Relationship between indices of iron status and coronary risk factors including diabetes and the metabolic syndrome in Saudi subjects without overt coronary disease. J Trace Elem Med Biol. 2007 21(4):242-54.

8. Pierre F, Tache S, Petit CR, Van der Meer R, Corpet DE. Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. Carcinogenesis. 2003 Oct;24(10):1683-90.

9. Stevens RG, Graubard BI, Micozzi MS, Neriishi K, Blumberg BS. Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer. 1994 Feb 1;56(3):364-9.

10. Mainous AG 3rd, Gill JM, Everett CJ. Transferrin saturation, dietary iron intake, and risk of cancer. Ann Fam Med. 2005 Mar-Apr;3(2):131-7.

11. Nelson RL. Iron and colorectal cancer risk: human studies. Nutr Rev. 2001 May;59(5):140-8.

12. Moyo VM, Makunike R, Gangaidzo IT, et al. African iron overload and hepatocellular carcinoma. Eur J Haematol. 1998 60:28–34.

13. Thompson KJ, Shoham S, Connor JR. Iron and neurodegenerative disorders. Brain Res Bull. 2001 55:155–64.

14. Sian-Hülsmann J, Mandel S, Youdim MB, Riederer P. The relevance of iron in the pathogenesis of Parkinson's disease. J Neurochem. 2011 Sep;118(6):939-57.

15. Jeong SY, Rathore KI, Schulz K, Ponka P, Arosio P, David S. Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci. 2009 Jan 21;29(3):610-9.

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By DDye - 9/18/2013 4:08:39 AM
Any members who believe that Life Extension supplements are causing a particular symptom or symptoms, please email me your name and address along with a description of the symptom, the name of the product you are taking and the lot number from the bottle.

Thank you.

D Dye
ddye@lifeextension.com
By Tom. - 10/22/2011 3:12:39 AM
In the old forum someone experienced the same joint pain side effect and posted a topic on it. (link)

Resveratrol has been shown to increase nitric oxide, via an increase in nitric oxide synthase. (link)

A study published in 2006 shows a potential, direct relationship to nitric oxide production and arthritis. (link)

A 2008 article talks about both a catabolic and protective role of nitric oxide in inflammation and pain of arthritis. (link)

Arginine and citrulline are amino acids that can raise nitric oxide production. Arginine can also be metabolized from the combination of citrulline and aspartic acid.

Based upon this information It may not be the resveratrol itself but the accumulative sum of all things increasing nitric oxide production.  If this theory is correct maybe you should reduce your intake of foods or supplements that are high in arginine or citrulline while taking resveratrol and see if that helps.

Based upon this information the direct relationship may be for some:  resveratrol > nitric oxide > inflammation > joint pain.

-Tom
By albedo - 10/23/2011 1:29:15 AM
I developed a mild tendinitis and have small signs or arthritis on my shoulder. It migth be a pure coincidence but will give resveratrol a break even at the low doses I have been taken (similar to your 75mg) and see what happens, while following physiotherapy. A good place to search information (but by no means the only one, it is simply another forum I am followig) is http://www.longecity.org ("maxwatt" writes a lot there on his experience with resveratrol)
By albedo - 10/30/2011 10:02:12 AM
COQ10 (10/23/2011)
Albedo,

We now have Krill oil for inflammation!!!

r

Yes I know that COQ10 (btw there is an interesting article on this in the last LEF magazine). Have you any particular experience you can report on using krill? I might give a try maybe with my wife who suffers of osteoarthritis (OA) in her hands. We are very carefully about inflammatory nutrients and regularly check blood CRP which plummeted since we take care (not sure though if CRP is good indicator of inflammation due to OA). Thank you for your suggestion.
By Tom. - 11/9/2011 10:37:24 PM
DDye,
As the "editor" do you laugh, sigh, or shrug your shoulders and wonder why? Wink
-Tom