Anyone taking TA-65


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By sami - 4/24/2011 1:20:32 PM
Currently taking TA-65 along with many LE supplements.  Anyone on the boards also taking this for telomere lengthening?
By MrGeorge - 4/24/2011 9:19:46 PM
This link may be interesting regarding TA-65.

http://www.longecity.org/forum/topic/31987-pure-cycloastragenol-is-now-available/
By LouD - 4/26/2011 2:39:02 AM
I took Astral Fruit for a while. I stopped because I saw no effects from it (unlike PQQ), and the Revgenetics guy didn't get any improvement when he had his telomeres tested.
By LouD - 4/26/2011 5:02:48 AM
syntax (4/25/2011)
    I will mention Dr. Denham Harman`s research again for those who are unaware of it and his results with BHT [ butylated hydroxytoluene ]. Those mice he dosed with BHT lived on average 40% to 50% longer. His critics claimed all he did was prevent the BHT dosed mice from getting cancer. Well if cancer is the big problem with maintaining telomere length, BHT and related compounds is at least part of the answer. This BHT as a life extender is far from being Dr. Harman alone`s opinion. I recently ran across a PHYSIOLOGICAL REVIEWS article that rates BHT number one of all the different compounds tested as a life extender for mice. I will dig up that article and post it :http://physrev.physiology.org/content/87/4/1175/T3.expansion.html%C2%A0
   There is not even a close second to BHT as a mean, or on average lifespan extender. You guys can laugh at me all you want, this BHT stuff really is a big deal.   ...syntax
    


If you look up one of the papers that showed an effect on mouse mortality, you find this:

Most of the increases in mean survival time were related to a reduction in early deaths (350--600 days) in BHT-treated mice.


Which isn't the same as life extension. Harman, too, found that maximum life span was not increased in mice, and became convinced that aging was a function (or dysfunction) of mitochondria. So it would be interesting to see a mouse study of PQQ + BHT.
By LouD - 4/27/2011 6:18:10 AM
syntax (4/27/2011)

   Anyway, YOU DO SEE the connection with maintaining telomere [ and hopefully increasing ] length and preventing cancer. Simple enough, right ? There seems to be a lot of evidence that having youthful telomere length can cause cells to remain youthful. The big downside has been a corresponding increase in cancer rates. So, if BHT can go a long ways as to preventing cancer, who can say what the results will be.


Yes, I agree that there is an inverse relationship between telomere length and cancer. The longer the telomeres the less the incidence of cancer. But you seem to be saying that long telomeres both prevent cancer and increase it. It's one or the other, not both.
By LouD - 4/27/2011 7:07:03 AM

Here's an interesting article which suggests that astragaloside IV is actually harmful to telomeres, cycloastragenol is neutral to slightly positive, while astragalus root plus extract is quite positive.

By LouD - 4/27/2011 8:44:09 AM
syntax (4/27/2011) There is an INCREASE IN CANCER RATES when telomere length is manipulated in such a way as to increase or maintain youthful telomere length. 


Maybe, but I haven't seen anything other than speculation on this. This article suggests the opposite:

Compared with individuals with the longest telomeres, those with the shortest were three times as likely to develop cancer over a 10-year period (HR 3.11, 95% CI 1.65 to 5.84), according to Stefan Kiechl, MD, of Innsbruck Medical University in Austria, and colleagues.

Those with the shortest telomeres were also 11 times more likely to die from cancer (HR 11.11, 95% CI 2.61 to 47.36), the researchers reported in the July 7 issue of the Journal of the American Medical Association.

By LouD - 4/27/2011 10:32:36 AM
If you look at the other link I posted, the one for astragalus root compared to Astragaloside IV and cycloastragenol, you'd see that the telomeres weren't increased uniformly over the six month trial:

"Standardised Astragalus Root Extract"

Lymphocytes: 7.0-6.9 = reduction of 0.1 kb
Granulocytes: 7.3-7.6 =Increase of 0.3 kb
Naive T-cells: 7.9-8.1 = Increase of 0.2 kb
Memory T-cells: 5.7-5.8 = Increase of 0.1 kb
B cells: 8.2-8.2 = No change
NK cells: 4.1-5.9 = Increase of 1.8 kb

So his NK cells (which are cancer fighting cells and had relatively short telomeres to begin with) got a big boost, while the others were almost unchanged over this 6 month period.
By sami - 4/27/2011 8:33:38 PM
Guys:

  TA-65 works by lengthening the short telomeres not extending the long ones.  It can be purchased from TA Sciences and from anti aging doctors who have a license to sell it.  Cost is 1,000.00 for a six months supply or 120 caps.  TA-65 is patented by Geron who discovered it in the process of making a cancer drug which is currently marketed under another name.  Dr. Calvin Harley one of the inventors of TA-65 still takes it regularily as do almost all of the people who were involved with it.  You can look up their studies as well as see most of them on You Tube, their stories are interesting.

 RevGenetics Astral Fruit is a mixed formula of Astragaloside IV .27 mg, Cycloastraganol 5.44 a capsule along with some enhancing factors like Purslane.

TerraEternal sells Astragaloside IV and is available on the web also, they are highly thought of by the Astragalus community.

You may not "feel" any benefits which is why they like you have testing for telomere length before you start and then again at the 3 month mark.  Most of us do notice some difference in stamina, and resistance to colds.  I found that all of a sudden one day I stayed with my PX90 workout all the way to the end and wasnt wasted.  One of the original founders found his time running a marathon increased and he was beating people who he formerly couldnt beat.  Some report lot more energy, I was very, very sleepy for the first three weeks instead.

There are studies that can be easily read by just googling  TA-65.   Jim Green has a interesting website at greentry.fortuncity.com/longevity and I understand Google has several blogs also.  Dr. Aubrey de Grey at The Immortality Institute in Cambridge, England has alot of information and studies on Astragalus and TA-65. 

Jim Green's site is interesting because he has taken over the counter Astragalus products not the designer variety and tracked his progress.  They seem to work and turned his grey hair back to almost black. 

  None of this stuff is the magic pill, its a synergy of factors including hormone balance, as well as good supplements and exercise which is as important as any pill you will ever take.

Hope this helps answer some questions.
By LouD - 4/28/2011 12:56:56 PM
Here's a forum with more than 1,200 posts on the subject of "Astragalus, Astragaloside IV and telomerase."


By sami - 4/28/2011 2:01:13 PM
Lou

 The Vida link was interesting, too bad he didnt include a source for high grade whole root.  I dont recall him mentioning cycloastragenol which is what is probably in TA-65.

 Enjoy your posts Lou, but I cant see a link on your last post.
By LouD - 4/30/2011 1:46:08 AM
sami (4/28/2011)
Lou

 I cant see a link on your last post.


The link was in the word "posts," but here it is, naked:

http://www.longecity.org/forum/topic/19921-astragalus-astragaloside-iv/

GreenPower is the poster there who did the self experiment where he found that regular astragalus (225 mg extract + 250 mg raw root powder) was the only one that worked (compared to astragaloside IV or cycloastragenol, see post #1077), and Anthony Loera is the guy selling Astral Fruit. Loera now seems convinced that his product isn't working. (Not the first time, apparently, as he's reformulated it at least twice already. See his post #1257.)

GreenPower's positive result for NK cells is interesting, but keep in mind it is only one data point for one individual for one cell type.


By sami - 5/7/2011 12:33:23 PM
I have been experimenting with topic application of Astragalus on skin.  Currently I am applying a drop each day to a brown, blat mole to see what it does?  So far after one week I notice it appears to be breaking up?  Will continue to observe this and report what happens.

Sammi
By LouD - 5/9/2011 8:33:52 AM
sami (5/7/2011)
I have been experimenting with topic application of Astragalus on skin.  Currently I am applying a drop each day to a brown, blat mole to see what it does?  So far after one week I notice it appears to be breaking up?  Will continue to observe this and report what happens.

Sammi



That sound potentially dangerous. In any case, I found this study to be interesting:

People with large numbers of moles may age slower than expected, according to a study from King's. Researchers studied the skin and telomere length (a marker of biological ageing found on all cells in the body) of more than 1800 twins and found that people with a high number of moles had longer telomeres.

http://www.kcl.ac.uk/news/news_details.php?year=2007&news_id=604
By sami - 5/10/2011 6:20:00 PM
Lou:

 Why do you think applying Astragalus Root a drop to a skin mole would be dangerous?  I dont follow your reasoning?  So far I think it definitely does improve skin when applied topically.  I put some on my arms and the top layer flaked off leaving beautiful luminescent skin.

I am now mixing some drops in a cream and applying it.
By webcityUS - 7/16/2011 2:35:57 PM
Im starting on Immune Factor A, From Longevity Medical Center, Kirkland WA.

It has 6 mg Astragaloside IV.

http://www.longevitymedicalclinic.com/shop/product-info.php?pid115.html

It is less than 1/10th the price of the TA65 I took for a month.
By rich1136 - 8/12/2011 5:26:37 PM
Where are you getting T-65 for $1,000 for six months treatment?  I understand that the treatments are much more expensive.  If the real thing can be obtained for that amount, I am interested in contacting the folks who are making that possible.
By John2004 - 8/16/2011 3:13:37 PM
Even "if" T-65 works & turns out to be safe, it sounds far too expensive to benefit anyone but the wealthy. I can't believe anyone would spend this kind of money on something without some serious proof that the stuff really works, works fantastically well, and is safe. 
By Transpower - 8/22/2011 3:07:25 PM
I've been taking Solgar Astragalus Root Extract (225 mg extract, 250 mg root powder) for about a year now.  A bottle of 60 capsules costs only about $17, which is far, far less than what the makers of TA-65 are charging. Your one person/one data point makes me feel good about this supplement, but obviously much more research is needed.  Originally, my intention was solely to help immune function in flu season; the supposed increase in telomere length would certainly be a bonus.
By sami - 8/26/2011 2:23:09 PM
Geron's Astragalus based cancer drug is entering human trials soon.  Also Isagenix just introduced Product B a telomere activator developed by the master  formulator John Anderson of Dream Labs one of the original chemists on TA-65.  This product contains a lot of what was thought to be inhibitors of TA-65 by Geron and users were advised not to take both at the same time.  However one of the original developers of TA-65 has included these products, Resveratrol, Curcumin, Green tea in his formulation.  Anderson has conducted and screened numerous chemicals and combos for Product B.  Bottom line, if the guy that formulated the original says this stuff is working, my money is on him.
By LouD - 11/21/2011 7:43:39 AM
Here is a recent paper on the Patton Protocol: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045570/

The bottom line:

TA-65® activated telomerase in cultured human cells at concentrations seen in the plasma of subjects on the protocol. Paradoxically, although ≈40% of subjects showed an increase in mean telomere length over time, on average across all subjects there was a nonsignificant decline in mean telomere length.

The authors then wave their hands trying to explain this away by saying that there were fewer cells with short telomeres in a majority of subjects (of 13 total), but there's really nothing paradoxical about it, seems to me. The reduced number of cells with short telomeres could be the result of cell death. Also, there were relatively few subjects (13 is not enough) and no control subjects.

BTW, RevGenetics is now selling 30 caps of TA-65 for $220, which seems rather expensive for something that might not work.
By LouD - 11/24/2011 2:14:01 AM
Tom. (11/24/2011)
TA-65 is so, so, so expensive.  Something for the rich and famous.  I guess if I had millions of dollars I may take it. Of course after I researched it completely to see if there may be any side effects. The more things you add to your regimen that allow cells to divide or replicate or not die off you increase your chances of cancer equally.



In my opinion, the best and most effective longevity combination is PQQ and Astragalus* root extract, which together cost less than a dollar a day. So it's not just for the rich and famous. And as was discussed previously, telomere length has been found to be inversely related to the incidence of cancer**.

*Patent: Formulations containing astragalus extracts and uses thereof

http://worldwide.espacenet.com/publicationDetails/description?CC=WO&NR=2005044179A2&KC=A2&FT=D&date=20050519&DB=&locale=en_EP

**Quote: Compared with individuals with the longest telomeres, those with the shortest were three times as likely to develop cancer over a 10-year period...

http://www.medpagetoday.com/HematologyOncology/OtherCancers/21032
By MrGeorge - 11/24/2011 5:12:23 PM

I haven't heard of this Astragalus mentioned before so did some checking, and still gathering some information.

I did find a forum where some members are trying it out and there may be some links to follow from there so here's the site :

astragalus at LONGECITY
By arta65 - 1/2/2012 7:27:30 AM
I'm glad someone else has reported feeling sleepy. I just started less than two weeks ago and I feel really, really sleepy .. as in noticeably more sleepy. I hope this is just some initial adjustment and I start feeling more energetic soon. On that note, I wish there were more articles on what to expect when you first start taking TA-65 and how your body adjusts. Another thing .. as I am 40, I opted to take the low dose (one pill a day), but I noticed that the clinical studies were done with 2 or 4, although it is possible that the participants were older. 
By Trev Aussie - 2/27/2012 1:01:24 PM
I have been consuming Product B since July last year. It is much cheaper than TA-65, being less that $25/week for a full dose. After reviewing many of Dr Ed Parks videos on Youtube (search : drpark65) regarding TA-65 and recieving many testimonies from people who are also using Product B, I believe Product B is just as potent if not even more so than the TA-65.

Product B was developed by Dr Bill Andrews and John Anderson. Dr Bill Andrews was one of the discoverers of human Telomerase and published a paper in 1998 showing that Telomerized human cells grown in Vitro become immortal. Included in Product B are substances that have been proven to be Telomerase Activators in vitro.

We have seen people who have experienced dramatic changes in conditions such as Alzhiemers, Parkinsons, Fibromyalgia, Prostate, Varicose Viens, joint problems and many other conditions. These changes tend to indicate that cells are regenerating.

Improved skin, more energy, improved mental clarity and better and deeper sleep, are just about reported by everybody who takes it.

http://tiny.cc/92yoAllenWilsonPB 

I have many other video testimonies as well from people who have been taking the Product B, and it certainly appears to be working incredibly well.

I believe Telomerase Activation will prove to be one of the greatest medical break throughs and will not only help many people who are already experiencing degenerative conditions, but will help many of us avoid them and allow us to live a healthy active life for much longer.

I am in the process of collecting Testimonials from people who have been taking Telomerase Activator products and I would love to recieve the testimonies of more people who have been on the products.
By coochie - 2/28/2012 7:31:12 AM
Recent research indicates that teloremase activation increases the aggressivenss of prostate cancer in mice. In fact the researches postulated that chemotherapy may target natural ta. I would not take TAs under any conditions, even for free. Anecdotal test. mean little, factual research is everything. You can very easily improve the quality of your life with very safe, affordable supplementation. I would feel very sad and stupid if while taking TAs developed agressive prostate ca.
By LouD - 2/28/2012 7:56:19 AM
coochie (2/28/2012)
Recent research indicates that teloremase activation increases the aggressivenss of prostate cancer in mice. In fact the researches postulated that chemotherapy may target natural ta. I would not take TAs under any conditions, even for free. Anecdotal test. mean little, factual research is everything. You can very easily improve the quality of your life with very safe, affordable supplementation. I would feel very sad and stupid if while taking TAs developed agressive prostate ca.



But in a study of 1,000 humans, telomere length was found to be inversely correlated with cancer:

Incidence rates of cancer in the longest, middle, and shortest TL tertiles were 5.9 (95% CI, 3.9-9.0), 16.9 (95% CI, 12.9-22.2), and 22.8 (95% CI, 17.8-29.2), respectively. Source

And so what if it made one cancer more aggressive if it cut the rate of all cancers by a factor of 4?


By Trev Aussie - 2/28/2012 10:47:01 AM
coochie (2/28/2012)
Recent research indicates that teloremase activation increases the aggressivenss of prostate cancer in mice. In fact the researches postulated that chemotherapy may target natural ta. I would not take TAs under any conditions, even for free. Anecdotal test. mean little, factual research is everything. You can very easily improve the quality of your life with very safe, affordable supplementation. I would feel very sad and stupid if while taking TAs developed agressive prostate ca.


The research referred to above clearly indicates that telomerase activation increases the aggressiveness of prostate cancer in mice. The research had nothing to do with telomerase activation in humans. Mice do not age by Telomere shortening as do humans. Factual research in humans, not mice, is the only thing that will determine what happens in humans.

In the past a lot of factual research has been undertaken following observance of anecdotal findings. The research trials are setup to either prove or disprove what appears to be happening in the field.

The factual research in humans regarding the correlation between Telomere length and cancer incidence is reported in 'Fifteen-Year Follow-up of Association Between Telomere Length and Incident Cancer and Cancer Mortality'  and published in the JAMA . Incidence rates of cancer in the longest, middle, and shortest TL tertiles were 5.9 (95% CI, 3.9-9.0), 16.9 (95% CI, 12.9-22.2), and 22.8 (95% CI, 17.8-29.2), respectively.   Source 

In a recorded Podcast posted on 26th Feb 2012, Dr. Ed Park of Recharge Biomedical explains a new model of cancer based upon telomere erosion in stem cells. Actual cases of telomerase activation in cancer patients are discussed with Dr. Miki Shima. Dr Park states that of about 7,000 people who have been taking a Telomerase Activator he is only aware of 2 people who have been diagnosed with new cases of primary cancer.


The recorded podcast and the anecdotal results of cancer patients given a Telomerase Activator can be viewed by clicking here.
By Free10 - 3/8/2012 7:00:35 PM
I have been doing the vitamins and powders and all the rest since about 1980 and I say forget those and get the TA65. There is absolutely no comparison to it and all the rest sold today, with its age reversing effects over months and the worse shape your in probably the better. The capsules are fairly small and no real side effects seem to happen with it except some feel a little too tense or the blood pressure goes up some for a short period and then usually heads back for a more healthy level.
By LouD - 3/9/2012 2:45:47 PM
Free10 (3/9/2012)
I have been doing the vitamins and powders and all the rest since about 1980 and I say forget those and get the TA65. There is absolutely no comparison to it and all the rest sold today, with its age reversing effects over months and the worse shape your in probably the better. The capsules are fairly small and no real side effects seem to happen with it except some feel a little too tense or the blood pressure goes up some for a short period and then usually heads back for a more healthy level.



How do you know it's helping you?
By Free10 - 3/10/2012 9:25:55 AM
LouD (3/9/2012)
Free10 (3/9/2012)
I have been doing the vitamins and powders and all the rest since about 1980 and I say forget those and get the TA65. There is absolutely no comparison to it and all the rest sold today, with its age reversing effects over months and the worse shape your in probably the better. The capsules are fairly small and no real side effects seem to happen with it except some feel a little too tense or the blood pressure goes up some for a short period and then usually heads back for a more healthy level.



How do you know it's helping you?




Changes to the way I move, balance, and energy both mentally and physically. Changes to nails, toenails, skin. pain above knees when climbing a ladder or squatting down went away. Seem to stand straighter and have more flexibility. It is slow to see the changes over weeks and months and I have been taking it for a total of about 7 months, but not 7 months in a row. I was 63 when I started and rated 160% disabled by the VA (100% COPD and 60% spinal damage from Ankylosing Spondylitis). My O2 readings on my finger oximeter seem to be climbing and pulse levels dropping.

I was in bad enough shape to know if it did anything I would be able to see it, and I have 3 decades of experiences with of many other substances. I did a video myself on much of my body and face the first day I started it (March 1 2011) so I could see the changes, if any over time, and to document any changes visually. Boy was I in bad shape then. Watched the videos in the last few nights. Yuck super yuck LOL I get a VA check up and blood work done every 6 months so I have those records.

In the first few months I seemed to see more clearly and went from a shuffling gait (didn't know I was shuffling till the change happened back) to a much wider more powerful steps and I noticed to make a quick turn, at a stand still, I was pivoting on my heels again naturally and without effort.

This is just a brief sketch of how I know.

My lungs/respiration still is bad but not as bad as it was it seems, and any repairs take time and it seems to be doing them every day cell by cell and thats throughout my body.
By LouD - 3/17/2012 5:51:00 AM
Free10 (3/10/2012)
LouD (3/9/2012)
Free10 (3/9/2012)
I have been doing the vitamins and powders and all the rest since about 1980 and I say forget those and get the TA65. There is absolutely no comparison to it and all the rest sold today, with its age reversing effects over months and the worse shape your in probably the better. The capsules are fairly small and no real side effects seem to happen with it except some feel a little too tense or the blood pressure goes up some for a short period and then usually heads back for a more healthy level.



How do you know it's helping you?




Changes to the way I move, balance, and energy both mentally and physically. Changes to nails, toenails, skin. pain above knees when climbing a ladder or squatting down went away. Seem to stand straighter and have more flexibility. It is slow to see the changes over weeks and months and I have been taking it for a total of about 7 months, but not 7 months in a row. I was 63 when I started and rated 160% disabled by the VA (100% COPD and 60% spinal damage from Ankylosing Spondylitis). My O2 readings on my finger oximeter seem to be climbing and pulse levels dropping.

I was in bad enough shape to know if it did anything I would be able to see it, and I have 3 decades of experiences with of many other substances. I did a video myself on much of my body and face the first day I started it (March 1 2011) so I could see the changes, if any over time, and to document any changes visually. Boy was I in bad shape then. Watched the videos in the last few nights. Yuck super yuck LOL I get a VA check up and blood work done every 6 months so I have those records.

In the first few months I seemed to see more clearly and went from a shuffling gait (didn't know I was shuffling till the change happened back) to a much wider more powerful steps and I noticed to make a quick turn, at a stand still, I was pivoting on my heels again naturally and without effort.

This is just a brief sketch of how I know.

My lungs/respiration still is bad but not as bad as it was it seems, and any repairs take time and it seems to be doing them every day cell by cell and thats throughout my body.


Had you previously tried astragalus extract (which is a hundred times cheaper)? And are you taking PQQ?
By Free10 - 3/17/2012 8:54:52 AM
LouD (3/17/2012)
Free10 (3/10/2012)
LouD (3/9/2012)
Free10 (3/9/2012)
I have been doing the vitamins and powders and all the rest since about 1980 and I say forget those and get the TA65. There is absolutely no comparison to it and all the rest sold today, with its age reversing effects over months and the worse shape your in probably the better. The capsules are fairly small and no real side effects seem to happen with it except some feel a little too tense or the blood pressure goes up some for a short period and then usually heads back for a more healthy level.



How do you know it's helping you?




Changes to the way I move, balance, and energy both mentally and physically. Changes to nails, toenails, skin. pain above knees when climbing a ladder or squatting down went away. Seem to stand straighter and have more flexibility. It is slow to see the changes over weeks and months and I have been taking it for a total of about 7 months, but not 7 months in a row. I was 63 when I started and rated 160% disabled by the VA (100% COPD and 60% spinal damage from Ankylosing Spondylitis). My O2 readings on my finger oximeter seem to be climbing and pulse levels dropping.

I was in bad enough shape to know if it did anything I would be able to see it, and I have 3 decades of experiences with of many other substances. I did a video myself on much of my body and face the first day I started it (March 1 2011) so I could see the changes, if any over time, and to document any changes visually. Boy was I in bad shape then. Watched the videos in the last few nights. Yuck super yuck LOL I get a VA check up and blood work done every 6 months so I have those records.

In the first few months I seemed to see more clearly and went from a shuffling gait (didn't know I was shuffling till the change happened back) to a much wider more powerful steps and I noticed to make a quick turn, at a stand still, I was pivoting on my heels again naturally and without effort.

This is just a brief sketch of how I know.

My lungs/respiration still is bad but not as bad as it was it seems, and any repairs take time and it seems to be doing them every day cell by cell and thats throughout my body.


Had you previously tried astragalus extract (which is a hundred times cheaper)? And are you taking PQQ?


I tried PQQ along with TA65 both for the first time in March 2011, so would be hard to evaluate the PQQ for me since there is a major shift with the TA65 alone in energy. I did try some astragalus IV just prior to March, but it or the regular astragalus root is not the same as the chemical in TA65 though it is found in trace amounts in some species of astragalus. Now imagine having to consume many pounds of root just to get out that one chemical found in one capsule of TA 65 and you see why it is expensive. There is a reason it is expensive and it is not greed. It is just it is very rare and expensive to extract.

If you wanted a cheaper way to tryout TA65 here is what I would do, now that I am a little more familiar with it. I would buy the 2 bottles, which are to provide 1 pill a day for 6 months dosage, and instead take 2-3 pills but every other day. This will give you a 4-6 month trial period with it and you may find medicines or vitamins you have been buying may no longer be needed over those months saving on there costs.

I like DHEA but it gives me urinary problems it seems now and my hair seems to want to thin out with it. Now the one thing that still works for me I like is DMAE powder, which I sprinkle in my coke. If it gives you a headache or tense neck and shoulders you are doing a tad too much LOL It has a tangy taste. I have taken it all the time for 3 decades. Pills and capsules of it cost more than powder. I use to take Tyrosine for decades as well too but stopped when LEF stopped selling the powder which was easy to put in my coke too and had no taste plus cheaper.

I need to reorder some DMAE and some other things to experiment with on getting rid of senescent cells even faster than what TA65 does.
By mtnrider - 3/24/2012 1:27:55 PM
If anyone is interested, I have an analysis of TA-65 that was done on Oct 19, 2010 by American Analytical Chemistry Lab Corp for TA-65 and the results for one (1) capsule were:

Astragaloside IV .27mg

Cycloastragenol 5.44 mg

It is reccomended to take 1 to 4 capsules per day (been on it for a year and I used to take 2/day and now take 1/day as it is so expensive).

I will be looking for a less expensive way to get the active ingredient cycloastragenol as the TA-65 cost and sales only through MD's (who have a healthy mark up) has gotten too much for me.

mtnrider
By coochie - 3/25/2012 2:20:10 PM
Either your analysis is wrong or TA is ripping you off. Look at Terraternal's web and  Astragaloside IV is 40mg per dose at 60/month (98% pure) and Cycloastragenol is 10 mg per dose at 80-160/month(?). Anyway I wouldn't take any TA sups. Take sulforaphane, cheap and wonderful.
By mtnrider - 3/26/2012 5:43:26 AM

I am quite certain the Lab analysis is correct, and at 10 mg per day (2 caps of TA-65) that makes the TA-65 about $300 per month. So, yes it is a bit excessive in profit when others, as you have indicated, produce and sell it at 1/2 the cost.

The current MD sellers of TA-65 have lots of anecdotal cases with their own theory as to why TA-65 is responsible for seen health improvements, but not one actual study published about TA-65 that I can find.

I really started out with high hopes, but after watching this for a few years, it appears to be very questionable. Seems like the MD sellers are operating in a strong conflict of interest setting, but are quite comfortable with the extra income TA-65 is making them.   Time for me to make a change and at least find sources for the main active ingredient, Cycloastragenol.

I am interested in how much sulforaphane you take and how long you have been taking it. What have you noticed with this supplement?

thanks,

mtnrider
By Free10 - 3/31/2012 6:02:56 PM
mtnrider (3/26/2012)

I am quite certain the Lab analysis is correct, and at 10 mg per day (2 caps of TA-65) that makes the TA-65 about $300 per month. So, yes it is a bit excessive in profit when others, as you have indicated, produce and sell it at 1/2 the cost.

The current MD sellers of TA-65 have lots of anecdotal cases with their own theory as to why TA-65 is responsible for seen health improvements, but not one actual study published about TA-65 that I can find.

I really started out with high hopes, but after watching this for a few years, it appears to be very questionable. Seems like the MD sellers are operating in a strong conflict of interest setting, but are quite comfortable with the extra income TA-65 is making them.   Time for me to make a change and at least find sources for the main active ingredient, Cycloastragenol.

I am interested in how much sulforaphane you take and how long you have been taking it. What have you noticed with this supplement?

thanks,

mtnrider


Each cap of TA65 is 8 mg (not 5) so 2 caps is 16mg and 4 are 32mg per day.

http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract
By mtnrider - 4/2/2012 6:33:51 AM
You are a bit confused...

My TA-65 bottles list 8mg of TA-65 per capsule, but they do not say what the 8mg is composed of...

Thus the value of a lab analysis.

The certified lab analysis, of which I am confident in, shows 5.44 mg of Cycloastragenol, the active ingredient, per capsule.   I have ordered this cycloastragenol at a much reduced price, from an online company which states 98% purity.  So, I will post when I get a chance to test it out and compare with the TA-65 that I have been taking. 

So far, I am a believer in the TA-65 and I am just trying to get the price a bit more reasonable by not having to go thru an MD marketeer with their substantial markup that they are adding to the product cost.

mtnrider
By Free10 - 4/3/2012 8:52:00 AM
mtnrider (4/2/2012)
You are a bit confused...

My TA-65 bottles list 8mg of TA-65 per capsule, but they do not say what the 8mg is composed of...

Thus the value of a lab analysis.

The certified lab analysis, of which I am confident in, shows 5.44 mg of Cycloastragenol, the active ingredient, per capsule.   I have ordered this cycloastragenol at a much reduced price, from an online company which states 98% purity.  So, I will post when I get a chance to test it out and compare with the TA-65 that I have been taking. 

So far, I am a believer in the TA-65 and I am just trying to get the price a bit more reasonable by not having to go thru an MD marketeer with their substantial markup that they are adding to the product cost.

mtnrider


The 8mg is the claimed active ingredient they call TA65 that they say is in the capsules, so I am not confused. And I know this, that any other supplier may not have any of what they are using in what they sell or it might have contaminants..might. Also this is a patented product and anyone trying to sell the same would be in violation of those patents from Geron and probably would be shut down fast.

Don't get me wrong I wish it was $5 a bottle and induced a lot more telomerase safely.
By coochie - 4/3/2012 9:22:29 AM
TA can be obtained, in original formula, thru Revgenetics for 2/3 what the docs are selling it for. I'm sure the docs order tests and charge for consultation, what a rip. Terraternal sells the main ingredients of TA. Sulforaphane is maybe my favorite sup. It can be obtained cheaply thru Vitacost's Broccolli sprout extract-2 caps supplying aorund 3 mg/2 caps. The advantage here is you are also getting glucosinolates, which are amazing liver detoxifiers. I also take Swans pure sulforaphane (0.4mg/cap) thruout the day. Sul is rapidly absorded and cleared, therefore frequent dosing is best. I try to take a total of 5mg/day. The benes of this chemeical are amazing. Taking it for 4-5 months and do not really feel any different. I felt pretty damn good before I started taking it. It prevents cancer, repairs joints and diseased blood vessels, it is great for eye health and chronic h. pyelori GI infections etc. But chlorogenic acid is great too. We are definitely living in the Golden Age of Supplementaion and very few MDs have a clue.
By mtnrider580 - 4/3/2012 9:50:46 AM
On the TA-65 bottles that I have been using, it clearly states as the sole ingredient:

"Astragalus Root Extract (TA65MD)     8mg"

The bottle does NOT state what that 8 mg is, and "Astragalus Root Extract" can mean anything extracted from the astragalus root...

The certified lab test showed what I stated earlier which is 5.44mg Cycloastragenol and .27 mg Astragaloside IV (lastly Astragenol at <.01mg).  You can believe a lab test or a product lable with no "details" as to what comprises the 8mg, it is you choice.  It seems good enough information for me to test out the Cycloastragenol. 

I am frustrated with this stuff being marketed only through high profit MD's that have a conflict of interest in pushing this stuff.  Some of the MD's are making more on sales of this than on their medical practise (similar to the Juice Plus my own MD pushes with full force on all patients, it is his major income generator!).  I am looking forward to giving the Cycloastragenol a try... if there are no results I will simply drop it.   BTW, as soon as the TA-65 mfr got wind on the report, they "immediately" pressured the web site that posted the report to pull it.  I was smart enough to get a copy before it was pulled.  Like you have stated, they may go after the cycloastragenol mfr as well since there is considerable money currently changing hands, but untill then, the cycloastragenol is available.
By Free10 - 4/3/2012 11:45:27 AM
Rev Genetics stopped selling it's version fast and started selling TA65 for the same price everyone else does. Rev Genetics is also the source for the claimed lab test. I have had a copy of it for a long long time and it is still available if you know where to look.

If you buy it from the doctors or TA Sciences web site the price is the same. I think the original idea of using doctors to sell it was because it was a new chemical being introduced in the population, that seemed totally safe and with their watchful eye on those buying it this added a layer of safety to the consumers if problems did pop up. Also they could be a good source for data on any benefits seen from it.

Now a days probably anyone can sell it and get it at discount if they are willing to pre order a large amount of it and sign contracts. Thats another thing, these doctors had to put up a large amount of their money to pre order a large amount of it to get any profit off of it...an investment. With only less than 10,000 people total taking it so far since they started years back I doubt any of them are making a killing off of it. Many people take it for 6 months and thats it, while some others use it longer depending on finances and their health goals.
By mtnrider580 - 4/3/2012 4:25:51 PM
Free10, it sounds like you are one of the sellers of TA-65 as you have provided much inside info, and it is appreciated. 

Rev Genetics did stop selling the Cycloastragenol because TA Sciences/Geron put legal pressure on them to stop.  Now Rev Genetics complains about the other firms selling Cycloastragenol... a complete about-face. 

The TA-65 does seem to produce results that I have noticed and if it is the Cycloastragenol, which it certainly appears to be, I sure hope a double blind study of one of two will be forthcoming in the near future.  The subject of telomeres and telomerase activators represents the most compelling explanation of sickness and ageing I have ever seen.  

LE needs a supplement called TA-66 and put everything that is currently known to lengthen/support telomeres as ingredients.  And, of course, keep evolving the ingredients as new discoveries are made.  It would be an absolute hit.
By Free10 - 4/3/2012 10:53:49 PM
coochie (4/3/2012)
TA can be obtained, in original formula, thru Revgenetics for 2/3 what the docs are selling it for. I'm sure the docs order tests and charge for consultation, what a rip. Terraternal sells the main ingredients of TA. Sulforaphane is maybe my favorite sup. It can be obtained cheaply thru Vitacost's Broccolli sprout extract-2 caps supplying aorund 3 mg/2 caps. The advantage here is you are also getting glucosinolates, which are amazing liver detoxifiers. I also take Swans pure sulforaphane (0.4mg/cap) thruout the day. Sul is rapidly absorded and cleared, therefore frequent dosing is best. I try to take a total of 5mg/day. The benes of this chemeical are amazing. Taking it for 4-5 months and do not really feel any different. I felt pretty damn good before I started taking it. It prevents cancer, repairs joints and diseased blood vessels, it is great for eye health and chronic h. pyelori GI infections etc. But chlorogenic acid is great too. We are definitely living in the Golden Age of Supplementaion and very few MDs have a clue.


http://denvernaturopathic.com/sulforaphaneandmyrosinase.htm
By Free10 - 4/4/2012 11:47:08 AM
mtnrider580 (4/3/2012)
Free10, it sounds like you are one of the sellers of TA-65 as you have provided much inside info, and it is appreciated. 

Rev Genetics did stop selling the Cycloastragenol because TA Sciences/Geron put legal pressure on them to stop.  Now Rev Genetics complains about the other firms selling Cycloastragenol... a complete about-face. 

The TA-65 does seem to produce results that I have noticed and if it is the Cycloastragenol, which it certainly appears to be, I sure hope a double blind study of one of two will be forthcoming in the near future.  The subject of telomeres and telomerase activators represents the most compelling explanation of sickness and ageing I have ever seen.  

LE needs a supplement called TA-66 and put everything that is currently known to lengthen/support telomeres as ingredients.  And, of course, keep evolving the ingredients as new discoveries are made.  It would be an absolute hit.


I indeed did check out trying to get a distribution deal with TA Sciences on it a little over a year ago though I am not a doctor and found out some of the way it seems to be setup. I have been following the subject of telomerase immortalization of cells since Mike West's Geron earliest days. But really had second thoughts on doing it and didn't.

A lot of people are trying to find something that works as well as TA65, but they have to realize many others like Geron and Sierra Sciences have been doing this for many years now already with their high volume testing labs. Geron has found some but all are patented by them. Geron is suppose to take one of them and put it into clinical trials soon or hoping too. Bill Andrews has said he has found about 40 of them, but they are either weak inducers or toxic, or both. I am afraid where the technology is going on disease and aging with telomerase and senescent cells LEF might not be able to go. My suggestion to them is to find things that may clean out senescent cells which grow larger by the year in percentage of our cells as we age, for now.

Think about this. If telomerase can keep our cells young and prevent the diseases known today then it will wreck a lot of research money, medical, and the whole nutrient field and not to mention the drug companies. Now, throw in regeneration and stem cells efforts and you really see the future. We will all still die sooner or later though from disasters and accidents. It is the nature of the Universe.
By sami - 6/21/2012 9:07:28 PM
Taking TA-65 again after a 6 month absence along with Product B by Isagenix.  Bill Andrews one of the scientists on TA-65 development team helped formulate this along with John Anderson of Isagenix.  Bill takes both TA-65 and Product B.  Product B is about to publish a year long study in human subjects this August. 

In starting Ta-65 I had to go through the two weeks of tiredness, and annoying short term memory farts, but seem to be stabalized now.  Also notice that sleep is deep, but shorter. 
By Lot Light - 6/25/2012 10:37:35 PM
WAKE-UP.

4 DAYS HAS PASSED SINCE ANY POSITIVE NEW POST.

THIS IS BEST APPROACH ON PLANET FOR EXTENDING LIFE.


Proof: http://www.longecity.org/forum/forum/6-supplements/     (464,997 views)

Where is everybody? On telomere sleep cycles? ;]




Q1: Is this good for helping to improve quality of life?
Q2: What are other compounds that work?
Q3: Are there simple ways that work?
Q4: Have any companies found chemicals or solutions for telomere extending?
Q5: Is telomere extending helpful? What if we forget about this... any other Waay?
Q6: Can we forgive the expensive solutions out there for this and come up with dataa?
By Free10 - 6/29/2012 4:23:03 PM
I for one have been in the hospital for about 40 day (spinal damage). Enough saidSmile
By Investigator - 6/30/2012 4:35:53 AM
I have been taking TA-65, full-dose ($8,000 @ year) for 2 years; my wife, for an illness, 1 1/2 - 2 times that dosage, for about 1 1/2 years.

I'm impressed by the science/research, & consider it so powerful, that we've pretty much stopped many of the telomerase inhibitors, including curcumin, quercetin, melatonin.

One could probably take those items 6-10 hours away from TA-65, but it seems some of the ways at least some of those supplements work, is similar to TA-65 -- i.e., by supporting immune system.

BTW, it seems the best way/time to take TA-65 is at bedtime, along with a small amount of fat; we generally use 1/2 tsp of cream cheese.

If you take the TA-65 as above, you will find you have more pronounced dreams.

In addition to info direct from T.A. Sciences, & although I've only consulted with him once or twice, I think Ed Parks, MD, is super knowledgeable & focuses his practice on TA-65 (I don't have any connectionSmile


http://www.rechargebiomedical.com/dr-park.php

Other than improvement in near-term vision -- as reported on TA-65 studies -- I don't know if I can point to any one thing I can say TA-65 has done, since I take 100+ supplements, anyway.

TA-65 is very expensive, but it is the only substance that has been shown to increase telomere length.
By mtnrider580 - 7/2/2012 5:42:42 AM
I also took TA-65 for about 1.5 yrs and had good results.  I am an avid bicyclist and general fitness person (now 58 yrs old).  But for the last 6 months, because of the high cost of the TA-65, I switched to taking the active ingredient in TA-65, Cycloastragenol, 25mg once a day, at night with coconut manna (which it totally delicious).  This is 5x the active ingredient of the TA-65 and costs me just $292 for 2 months worth  ($1800 per yr).

Anyway, my health is better than any point in my life, and I feel wonderful before, during and after the biking.  My performance has been steadily going up as I age!

I do eat healthy, and take a whole battery of supplements, mostly recommended by LEF via blood tests and then there is the workouts, which I believe are very important for me as well.  If I work out every day or every other day, I feel fantastic.  If I take more than one day off, I start to feel a bit sluggish and the workouts become a chore, my performance suffers and the life bliss dissipates a bit.  So it seem like it is everything I am doing is interrelated and right now I don't want to mess with the formula.

So my feeling is that if you can afford the TA-65 go for it.  If your supplement budget has some limits then take the Cycloastragenol (I do get the vivid dreams with it, just like the TA-65).  
By Lot Light - 7/5/2012 7:35:03 PM


....urcumin, quercetin, melatonin.

One could probably take those i


Hi, these items you call inhibitors... can you point to science for the negative effects? Smile
By spy1 - 7/29/2012 8:26:03 AM
At the risk of getting fussed at for not having read ALL six pages of this, I'd like to hazard a question - exactly how long does it take for TA-65 to maximize one's telomeres length? Is there a baseline, like a standard of how long they were when you turned 18 or 21 or something?

Once they're maximized, why would you continue taking the TA-65 rather than just getting off of it for a good while and just starting it back up again when a bloodtest (or whatever in the world you check telomere length with) indicates that you actually need to?

Or does it never actually maximize them totally back to what they were, thus making it necessary to take it, literally, forever?
By Free10 - 7/29/2012 9:04:38 AM
Baseline would be really at the time a person was conceived, or even born really, and by 18-21 the telomeres have already shortened. Besides this everyone would have differing lengths, according to life events and genetics for any set age.

How long you take it is up to the individual but getting off it the body starts returning slowly back to where it was and thats not good LOL

What I find interesting is no one asked mtnrider580 where they found their Cycloastragenol that worked well for them.
By mtnrider580 - 7/30/2012 12:12:24 PM
I get 60 caps of 25mg for about $290, every 2 months, auto-delivery, from www.crackaging.com.   I am the healthiest I have been in my entire life.  Frequent urination (irritated bladder?), prostate issues (very slow urination), ... everything gone.  Slow urination continues a bit and is not as fast as when I was in my 30's, but much better than before.

I feel great.  But remember, I do take a load of other, more typical vitamins and herbs as well and heavy aerobic and resistance exercise every other day.  My difficult and frequent urination issues were driving me nuts and having just that gone is a HUGE relief.  But the added benefit of just feeling wonderful and young is a big blessing.   I never get headaches or colds or anything.   And again, I am in no way affiliated crackagin.com or anyone in the supplement business.  I am a 58 yr old retired engineer, now gentleman farmer and mountain biker.  I had a very hard time finding out what was in the TA-65 as the info was pulled off the internet.  But once I got a copy of the lab report, I ordered this stuff and have never looked back.

The one lingering thing that has me wondering is why is there no double blind study on this stuff if it works so good?  It could be that all my other supplements are carrying the load, but without some hard data, I don't want to mess with what I am doing.  I never want to go back to the down hill, typical aging, spiral that I was in.
By Free10 - 7/30/2012 2:06:58 PM
mtnrider580 (7/30/2012)
I get 60 caps of 25mg for about $290, every 2 months, auto-delivery, from www.crackaging.com.   I am the healthiest I have been in my entire life.  Frequent urination (irritated bladder?), prostate issues (very slow urination), ... everything gone.  Slow urination continues a bit and is not as fast as when I was in my 30's, but much better than before.

I feel great.  But remember, I do take a load of other, more typical vitamins and herbs as well and heavy aerobic and resistance exercise every other day.  My difficult and frequent urination issues were driving me nuts and having just that gone is a HUGE relief.  But the added benefit of just feeling wonderful and young is a big blessing.   I never get headaches or colds or anything.   And again, I am in no way affiliated crackagin.com or anyone in the supplement business.  I am a 58 yr old retired engineer, now gentleman farmer and mountain biker.  I had a very hard time finding out what was in the TA-65 as the info was pulled off the internet.  But once I got a copy of the lab report, I ordered this stuff and have never looked back.

The one lingering thing that has me wondering is why is there no double blind study on this stuff if it works so good?  It could be that all my other supplements are carrying the load, but without some hard data, I don't want to mess with what I am doing.  I never want to go back to the down hill, typical aging, spiral that I was in.


Big double blind studies cost big big bucks and that's partially why they have not been done probably, but then again they are usually only done for FDA drug approvals which TA65 does not need, just to be out there with no medical disease treatment claims and aging is not a disease to them yet it seems to be the center for all diseases not caused by genetics, viruses, or bacteria.

The other things you take may help with different things and probably help with the healthy functioning of the body, but in my experience they work better when the cells are younger and seemed to lose effect as I aged when it came to basic nutrients. As long as you feel great and seem to be getting better over time I sure would not change anything LOL There may be better ways out there and I am looking around to see if maybe the TA65 chemical might work even better with say some of the other plant's extracts it is refined from now.

You might find this interesting LOL

http://www.youtube.com/watch?v=cosOjqRePtk&feature=plcp
By WilliamJ - 8/3/2012 10:57:18 AM
I am using the original TA-65 - very good stuff! You can order it (Europe) at www.anti-aging-labs.com. I am also in contact with Life Length (http://www.lifelength.com/) where you can have one of the best Telomere Tests in the world. All together not so cheap, but what's EUR 4,95 per day - some people do smoke or drink wine at the same price tag a day. It's all about choices.
By Lot Light - 8/13/2012 5:58:10 PM
Welp, not to spook anybody but it is true there is a lawsuit about Cancer and T-65.

While, I hope this is not the fact... someone should think about this and hope we can test harder and maybe have science to prove this is good stuff.

http://www.nature.com/news/lawsuit-challenges-anti-ageing-claims-1.11090
By Free10 - 8/14/2012 5:07:38 AM
Lot Light (8/13/2012)
Welp, not to spook anybody but it is true there is a lawsuit about Cancer and T-65.

While, I hope this is not the fact... someone should think about this and hope we can test harder and maybe have science to prove this is good stuff.

http://www.nature.com/news/lawsuit-challenges-anti-ageing-claims-1.11090


There is a lawsuit by an ex-employee the company claims was let go for lack of sales on his part, and he claimed he was required to take it and that a cancer he got must have come from taking it and that the company is not reporting the cancers gotten by those taking it. The science looks to be stacked against this lawsuit though, and it looks like a typical class action suit to reap a few bucks for some law firm in a settlement.

Cancers can exist for long periods before being noticed and diagnosed.
By Lot Light - 8/14/2012 3:11:48 PM
I hope that guy is ok.

I do think more tests should be conducted before human trials. There are some ideas on this in other forums. The human risk factor, if concluded is a non-issue for disease, ... then maybe it is really the eternal magic pill we have all been waiting for. Thanks
By Lot Light - 8/14/2012 3:17:21 PM
I also want to add it is unfair to link Cancer & T-65 together immediately.

It is also unfair to link "science is stacked against the cancer claim".

While nobody knows if this person took T-65 for a long period of time and if it caused the prostate cancer.

It is also unknown if such taking T-65 was for long enough to potentially cure the cancer or help in any other way.

While, these findings I think do not represent any true fact... it is food for thought and jumping to any CONCLUSIONS is wrong and unfair.

Hopefully the trial and evidence will come forward.
By Lot Light - 8/14/2012 4:25:02 PM
Also i hope the moderator(s) will think about future posts here and post messages forward to ethical standards.
By livelong&prosper - 8/21/2012 5:33:22 PM
Hey there,

Love all your posts...

I have had a look around the net and stumbled on the "war" over on another forum between Anthony from Revgenics and some guy wanting to start his own outfit in Europe. 

It seems Anthony is going to great pains to hide the lab test report on TA-65!

I tried to access it through some "secure link" he provided but it says "time expired" and doesn't let you.

Can someone email me the report?

sjoh7729@dodo.com.au ??

I'm about to start on 98% pure cycloastrogenol.

Thanks a million guys, cheers to a long life for all Smile
By livelong&prosper - 8/23/2012 5:15:10 PM
Hey guys,

Does anyone have the COA for the new TA-65 MD version ?

Apparently it is different slightly. All customers apparently get the COA of the new stuff so someone must be able to tell us. Smile

Cheers,
By Free10 - 8/23/2012 6:37:07 PM
livelong&prosper (8/21/2012)
Hey there,

Love all your posts...

I have had a look around the net and stumbled on the "war" over on another forum between Anthony from Revgenics and some guy wanting to start his own outfit in Europe. 

It seems Anthony is going to great pains to hide the lab test report on TA-65!

I tried to access it through some "secure link" he provided but it says "time expired" and doesn't let you.

Can someone email me the report?

sjoh7729@dodo.com.au ??

I'm about to start on 98% pure cycloastrogenol.

Thanks a million guys, cheers to a long life for all Smile


Here are the results of the COA and if you follow the link it leads to the COA and discussion

TA-65 according to the COA is:  Astragaloside IV - .27mg / serving  Cycloastragenol      Astragenol - .01mg / serving     Cycloastraganol - 5.44mg / serving

www.longecity.org/forum/topic/52792-ta-65-analysis-repost/
By Lot Light - 9/15/2012 5:40:41 PM
Hi there!

Sorry for delay in reply.

At least some basic sense into the mind of the author, so:

1] Posts are at least critical to positive or negative of this topic thread
2] Super long posts should be truncated and not posted or edited
3] Random posts or desires to 'craft' or by people posting many messages to obliterate cool posts is eliminated
4] Good questions are given time to be replied to

This is a good thread guys! I think the ladies and gentlemen out there would
love to see this forum really zone in on this amazing molecule.

Hopefully it is good. Thanks
By Jrrocco - 10/14/2012 8:39:07 AM
Anybody taking TA-65 or Astragaloside IV / Cycloastragenol noticing their facial skin firming up? If so how long did it take to see noticeable improvement if any?

Comments appreciated.

By Free10 - 10/14/2012 4:23:31 PM
Jrrocco (10/14/2012)
Anybody taking TA-65 or Astragaloside IV / Cycloastragenol noticing their facial skin firming up? If so how long did it take to see noticeable improvement if any?

Comments appreciated.



I think mine might be, but how long will depend on a lot of issues I think, such as age and how much you take. A recent study showed that taking omega 3s might also lengthen telomeres in some people over I believe 4 months, but no telomerase activity was measured.
By ruby - 10/18/2012 6:34:51 AM
Your info sounds inspiring.  I have been taking TA 65 for about 4 months now and honestly do not see
any change.  Same old aches and pains and no skin changes.  Perhaps, taking it for a longer period of time
will give a better comparison to the before and now.  I am currently am slowly changing my diet to include
more juicing and hopefully that will assist with perhaps nutrients that I may be missing.
Any suggestions would be appreciated. Thank you.
By sami - 12/22/2012 8:26:31 AM
I have been experimenting with whole astragalus root, using Gaia liquid ratio 1:1.5, 30 drops=1Ml.  Used 5 ml at bedtime for two weeks and again noticed a 3 pound weight jump.  I had the same thing with TA-65.  This is either water retention or something about Astragalus re-sets the hypothalmas and causes weight gain.  It could increase carbohydrate storage somehow? I also took too large a dose one day and had a huge problem with the runs the next day.   I dont understand the weight gain thing and actually called Dr. Parks regarding this, and he said his clients have not complained about it.

  During this time I felt good, not a burst of OMG energy but stamina, took it at bedtime and slept very soundly. 

  Also experimented with Product B which has since been reformulated.  Didnt notice much of anything but did not have a weight gain on it.  I am upset with Isagenix as they have not made their supposedly double blind study due out last August public.  I can only speculate its because it was dissapointing.  If you notice all the testomonials and marketing information never mentions specific studies done with Product B but only with telemere research in general which was mostly done with TA65.  Also some web published by Vida Institute showed the personal telemere before and after results taking cycloastragenol, astragalus, and whole root extract.  The whole root extract showed the most telemere lengthening for the short strands. 

  Seems these other products just do not have the credible science behind them that TA-65 does have, but I wish TA-65 and other users of like products would be more forthcoming with experiences, side effects to help all of us get a clearer picture of these relatively unknown substances for anti aging use.

Sammi
By casey mama - 12/27/2012 6:57:11 AM
I recently took the ALCAT Test which measures by blood work your sensitivities to over 300 various foods, herbs, chemicals, additives, etc., and my results showd a severe intolerance to Astralagus. Prior to the ALCAT Test, I had no idea what Astralagus even was. Then I read about TA-65 and wanted to take it but am afraid to.

Has anyone else had the ALCAT Test or aware of an allergy or sensitivity to Astralagus? I'm bummer not to be able to take advantage of the benefits of  TA-65.
Casey Mama
By Jeanneatthebeach - 2/19/2013 1:53:24 AM
I am new to the forum but not to LEF. I took TA-65 from Dr. Sears for 8 months. I could not see or feel any difference. However, I take a lot of supplements and eat very healthy. I assumed that was the reason.
By Lot Light - 8/2/2013 9:31:25 PM
Since February, this forum has lowered ... has T-65 proven as a major breakthru or is it a bomb? So many people testify that it looks great and maybe it is the future.
By Piper - 9/10/2013 10:26:23 AM

Personally I would have already tried TA-65 if it was not so expensive.  Frankly, I think they could make more money if the price was slashed because their sales would probably triple.   Then there would be more people doing reviews and therefore even more input…which would be great as well.   

Is there anything that is similar…that doesn’t cost over $200 a month?  Any info would be great!

By JohnMc - 9/23/2013 2:11:08 PM
I was interested in trying this product. Does it actually do what it claims to do or is it rubbish?
By JohnMc - 9/24/2013 4:12:26 AM
DDye (9/24/2013)
Welcome to the Forums, JohnMc.

D Dye
Moderator


Thanks D Dye
By xnlife - 9/24/2013 9:15:31 AM
Good proven multivitamin with calcium magnesium vitamin D resvratrol,and omega 3 Q10

Cost effective way to live longer!Pay less on health care 


Way cheaper than TA 65

xnlife is to extend life
By tonnyb - 3/28/2014 3:31:00 PM
Has you or anyone tried the Astragalus & PPQ combo and had pre and post testing of Telomere length?

Would love to here results.

Thank you
By xnlife - 3/31/2014 8:23:23 PM
OK I will bite {what is not that expensive ?} TA 65 cost per month is ?? 
For my supplements monthly cost is $85.00 per Month 

Good proven multivitamin with calcium magnesium vitamin D resvratrol,and omega 3 Q10

Cost effective way to live longer!Pay less on health care 
By Transpower - 4/1/2014 12:01:38 PM
Most people here take Astragalus, not TA-65.
By Aussie Girl - 4 hours ago
I've been taking it for 3 months. I'm 41 and noticed that a few grey hairs I pulled out were grey on the end ...and BROWN on the root end!! They had started growing with colour in them again. Amazing. 
Of course its not ALL my grey hairs but does prove the TA65 made a difference. (I noticed it after taking it for 3 weeks and it was 3 weeks worth of growth. My husbands a hairdresser and he confirmed it was 3 weeks of growth and there's no way greys start growing with colour gain once they've turned grey).

Also, I won a bottle of the TA65 Skin Cream which I don't want so am selling it on ebay (Australia) at $400 (RRP $500) and free international postage. If anyones interested please contact me 
By DDye - 4/4/2012 4:42:28 AM
To mtnrider, we wouldn't rule out the possibility, however . . . http://www.lef.org/magazine/mag2009/aug2009_Turning-on-Immortality-The-Debate-Over-Telomerase-Activation_01.htm
By DDye - 8/14/2012 4:34:01 PM
Lot Light, please explain.

Thanks.

D Dye
By DDye - 10/18/2012 6:45:59 AM
Welcome to the Forums, ruby.

D Dye
Moderator
By DDye - 12/27/2012 7:39:53 AM
Welcome to The Forums!

D Dye
Moderator
By DDye - 2/19/2013 4:13:41 AM
Welcome, Jeanne!

D Dye
Moderator
By DDye - 9/24/2013 4:11:04 AM
Welcome to the Forums, JohnMc.

D Dye
Moderator