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vitamin b12 folic acid

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 Posted 8/22/2013 8:01:24 AM
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Can vitamin b12 and eventually folic acid favor cancer? At what doses, time of assumption and age?

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 Posted 8/22/2013 11:08:51 AM
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Tumors cells use the B vitamin folate, as do healthy cells.  While studies have shown that folate has a protective effect against some cancers, once a cancer has developed, there are drugs that treat the tumor by starving it of folate. 

Since some individuals do not metabolize supplemental acid well, it appears to be better to supplement with folate, which is identical to the form of the vitamin provided by food.

While high vitamin B12 levels have been correlated with an increased cancer risk by some studies, i am not aware of a causative role for the vitamin. Nevertheless, new information is being published every day, and there are levels for every nutrient at which they are associated with adverse effects. 


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 Posted 8/31/2013 11:41:43 PM
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DDye (8/22/2013)
Tumors cells use the B vitamin folate, as do healthy cells.  While studies have shown that folate has a protective effect against some cancers, once a cancer has developed, there are drugs that treat the tumor by starving it of folate. 

Since some individuals do not metabolize supplemental acid well, it appears to be better to supplement with folate, which is identical to the form of the vitamin provided by food.

While high vitamin B12 levels have been correlated with an increased cancer risk by some studies, i am not aware of a causative role for the vitamin. Nevertheless, new information is being published every day, and there are levels for every nutrient at which they are associated with adverse effects. 

Agree. I think LEF is using folate in the Mix and B Complex right? For the active form L-Methylfolate this article can be useful: http://mthfr.net/l-methylfolate-methylfolate-5-mthf/2012/04/05/


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 Posted 9/1/2013 4:32:33 AM
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If you're taking B12 as an energy supplement, I would recommend Rhodiola as a substitute--it seems to work much better for most people.
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 Posted 9/1/2013 4:34:53 AM
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Transpower,

Thank you for all of your contributions.  You have been consistent in your efforts to help people over the years, and Life Extension appreciates it.

D Dye
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 Posted 9/2/2013 12:51:33 PM
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DDye, you are very welcome....
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 Posted 12/12/2013 1:01:57 AM
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After a median 39 months of treatment and an additional 38 months of post-trial observational follow-up, 288 participants (8.4 percent) who did not receive folic acid plus vitamin B12 vs. 341 participants (10.0 percent) who received such treatment were diagnosed with cancer, a 21 percent increased risk.
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 Posted 12/15/2013 11:06:18 AM
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It really doesn't make any sense to give those numbers without the 95% confidence intervals or at least a mention of to the study you are refering to. There are a few RCTs with folic acid which have observed a borderline-significant increase in cancer risk but the most recent and comprehensive meta-analysis published in Lancet did not.
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 Posted 12/26/2013 9:37:52 AM
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Transpower (9/1/2013)
If you're taking B12 as an energy supplement, I would recommend Rhodiola as a substitute--it seems to work much better for most people.


When I have several supplements under consideration, I start with substances we know the body requires, like B-12. They're usually cheaper and have a broader effect.

I've taken rhodiola. It's a great energy/mood supplement, but for people with chronic health problems, vegans and older people, B-12 is likely deficient and can cause problems besides low energy. Solving the energy problem alone may conceal other subtler issues. Happily there's a blood test for B-12.

Many people can't take stimulating supplements because of sleep issues or over-stimulation. Anyone with anxiety or sleep problems, or who gets over-amped from minor stressors may need to avoid stimulants.

I have found that calming supplements can boost energy. If you can calm yourself down enough, you get better rest and recovery. It takes longer to see results, but it's more lasting.

Elaine
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