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High fasting insulin with normal fasting glucose and a1c

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 Posted 8/5/2013 10:13:57 AM
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Anyone seen an odd blood test result like the following?
Glucose, Serum  - 80    mg/dL
Insulin         - 18.8 uIU/mL
Hemoglobin A1c  -  5.1 %

Insulin resistance like these results seem to imply would normally cause the other numbers to be much higher, right?


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 Posted 8/5/2013 4:44:14 PM
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Seems strange to me too. I would be interested in learning the cause if it is anything other than Lab error.

Almost looks like a healthy person with good glucose control and not insulin resistant decided to inject insulin just prior to the fasting blood test draw.
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 Posted 8/5/2013 6:46:42 PM
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Looks just like my condition, only much worse insulin level than mine (and I thought mine were bad).

My fasting insulin (~10) almost half yours but still more than double what LEF recommends --yet my glucose is 79 and A1c is 5.9.

Too high of insulin points towards some kind of insulin resistance problem, though I haven't figured out exactly what is going on with me yet. . .   I do have somewhat low HDL and slightly elevated blood lipids, but other than that, virtually everything in my blood work is, including ferritin levels is par excellence.  I got the motivation to lose 10 pounds to see if that was part of it, but still no.  I do have some family history of Type II diabetes and alzheimers, so likely a genetic component.

Any ideas here would certainly be welcome.



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 Posted 8/6/2013 5:31:52 AM
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My lipid panel/vap could use some major improvement as well. My current line of thought is that I have some sort of defect involving threonine/glycine/serine metabolism as they are all low on my amino panel. All my other essential/conditionally essential aminos are pretty good. I started taking glycine immediately after this test so hopefully it will make some improvement. The studies I have seen seem to indicate its possible that it would.

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 Posted 8/21/2013 9:40:21 AM
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After adding extra glycine to my daily intake (currently 24g/day) my levels have dropped a bit in only 2 weeks. Hopefully its on a trend downwards.
Glucose, Serum  - 77    mg/dL
Insulin         - 16.5 uIU/mL

That amount of glycine normalized my glycine blood level, but I probably don't need that much, so I will be tapering down to see how much I actually need. Switching to 12g/day today.
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 Posted 2/23/2014 4:01:19 PM
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I'm going to go back and be tested again in a few weeks. I think it may be related to the amount of manganese I have needed to take to have a normal manganese blood level. In 2012 it was taking over 50mg/day to balance (~ 5x UL), slowly it went down to 30mg/day and now I'm down to 16mg/day. Even 16mg/day is quite high though (~ 1.5x UL) and manganese deficiency has been associated with insulin and diabetes problems.
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