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High fasting insulin with normal fasting glucose and a1c

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 Posted 8/5/2013 10:13:57 AM
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Anyone seen an odd blood test result like the following?
Glucose, Serum  - 80    mg/dL
Insulin         - 18.8 uIU/mL
Hemoglobin A1c  -  5.1 %

Insulin resistance like these results seem to imply would normally cause the other numbers to be much higher, right?


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 Posted 8/5/2013 4:44:14 PM
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Seems strange to me too. I would be interested in learning the cause if it is anything other than Lab error.

Almost looks like a healthy person with good glucose control and not insulin resistant decided to inject insulin just prior to the fasting blood test draw.
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 Posted 8/5/2013 6:46:42 PM
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Looks just like my condition, only much worse insulin level than mine (and I thought mine were bad).

My fasting insulin (~10) almost half yours but still more than double what LEF recommends --yet my glucose is 79 and A1c is 5.9.

Too high of insulin points towards some kind of insulin resistance problem, though I haven't figured out exactly what is going on with me yet. . .   I do have somewhat low HDL and slightly elevated blood lipids, but other than that, virtually everything in my blood work is, including ferritin levels is par excellence.  I got the motivation to lose 10 pounds to see if that was part of it, but still no.  I do have some family history of Type II diabetes and alzheimers, so likely a genetic component.

Any ideas here would certainly be welcome.



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 Posted 8/6/2013 5:31:52 AM
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My lipid panel/vap could use some major improvement as well. My current line of thought is that I have some sort of defect involving threonine/glycine/serine metabolism as they are all low on my amino panel. All my other essential/conditionally essential aminos are pretty good. I started taking glycine immediately after this test so hopefully it will make some improvement. The studies I have seen seem to indicate its possible that it would.

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 Posted 8/21/2013 9:40:21 AM
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After adding extra glycine to my daily intake (currently 24g/day) my levels have dropped a bit in only 2 weeks. Hopefully its on a trend downwards.
Glucose, Serum  - 77    mg/dL
Insulin         - 16.5 uIU/mL

That amount of glycine normalized my glycine blood level, but I probably don't need that much, so I will be tapering down to see how much I actually need. Switching to 12g/day today.
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 Posted 2/23/2014 4:01:19 PM
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I'm going to go back and be tested again in a few weeks. I think it may be related to the amount of manganese I have needed to take to have a normal manganese blood level. In 2012 it was taking over 50mg/day to balance (~ 5x UL), slowly it went down to 30mg/day and now I'm down to 16mg/day. Even 16mg/day is quite high though (~ 1.5x UL) and manganese deficiency has been associated with insulin and diabetes problems.
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 Posted 10/7/2014 5:51:20 AM
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I have a similar profile and it seems to be indicative of mild metabolic syndrome. I am diabetic and have my glucose controlled rather well, but the underlying metabolic syndrome usually shows up as high fasting insulin. One important supplement that is usually not mentioned is d-chiro-inositol. The formula that Swanson Vitamins carries pairs inositol with manganese. It is highly effective in decreasing insulin resistance. For some reason LEF has never delved into this supplement.

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 Posted 10/7/2014 9:13:43 AM
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On the bright side, your pancreas is still able to produce insulin. Its probably not too late to correct the situation. With fasting insulin elevated, I would assume the postprandial insulin response to be exaggerated as well. This can go on for a long time before it begins to show up as high serum glucose (fasting or postprandial) and/or high A1c.

This is why so many "pre-diabetics" are told they are OK when they are actually on the fast-lane toward diabetes. A1c and fasting glucose may seem relatively normal but the insulin response isn't normal and its hard to check (and is rarely ever done). Over time it takes more and more insulin to store away the same amount of glucose and eventually pancreatic function begins to go down in a blaze of glory. When it can't release enough insulin to normalize serum glucose, symptoms begin and we see a rise in fasting glucose, high A1c, etc.

I wish I had known these things 20 years ago. My pancreas still releases Insulin but I've become a bit numb to its effects hence I am fairly carbohydrate intolerant, especially in the morning. Now, I eat accordingly.

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 Posted 10/7/2014 12:15:54 PM
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Over time I've managed to get my fasting insulin down to 11.5, it dropped from 20.1 to 11.5 in about a month. I made several changes during that time, but only one thing I hadn't previously messed with. I started taking 5-HTP 3x/day, after noticing some apparently important defects in my TPH2 gene, which may be what helped lower it.

Edit: I also used a sauna a few weeks during that time which may have had an effect as well. So its likely between 5-HTP or sauna use.
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