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Starving cancer cells

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 Posted 7/23/2013 6:50:57 AM
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"Scientists develop ground-breaking new method of ‘starving’ cancer cell"

"...Chris Proud, Professor of Cellular Regulation in Biological Sciences at the University of Southampton says: “Cancer cells grow and divide much more rapidly than normal cells, meaning they have a much higher demand for and are often starved of, nutrients and oxygen. We have discovered that a cellular component, eEF2K, plays a critical role in allowing cancer cells to survive nutrient starvation, whilst normal, healthy cells do not usually require eEF2K in order to survive. Therefore, by blocking the function of eEF2K, we should be able to kill cancer cells, without harming normal, healthy cells in the process...”

http://www.southampton.ac.uk/mediacentre/news/2013/jul/13_129.shtml

The paper is here:

http://www.sciencedirect.com/science/article/pii/S0092867413005321
Post #9608
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 Posted 7/23/2013 11:09:04 AM
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That looks very promising.  This is somewhat similar to the old idea of blocking blood flow to tumor cells.
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 Posted 7/25/2013 4:44:11 AM
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Let's wish him good luck (bold mine):

"...Thirdly, the fact that eEF2K is so tightly regulated implies it lays important role in controlling protein synthesis, and we are studying several aspects of this, e.g., its role in cancer cells, its function in heart and muscle physiology, and its role in controlling synaptic protein synthesis during learning and memory consolidation..."

http://www.southampton.ac.uk/biosci/research/projects/structure_function_and_regulation_of_eukaryotic_elongation_factor_2_kinase.page?
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 Posted 9/4/2013 10:04:36 AM
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Another way of starving cancer cells is diet, specifically NO SUGARS and other white offending foods like gluten.  A strict paleo diet can be very helpful.  Google starving cancer diet and you can watch a video that talks about it. 
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 Posted 12/12/2013 12:57:52 AM
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Cancer cells grow and divide much more rapidly than normal cells, meaning they have a much higher demand for and are often starved of, nutrients and oxygen.
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 Posted 12/14/2013 8:31:09 AM
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CZMUIR (9/4/2013)
Another way of starving cancer cells is diet, specifically NO SUGARS and other white offending foods like gluten.  A strict paleo diet can be very helpful.  Google starving cancer diet and you can watch a video that talks about it. 

I am just finishing reading Xandria Williams's "Vital Signs for Cancer prevention" (here). The book is a mine of recommendations, some of them quite new to us. We know about sugars but it is always good to see it repeated: "... If you do nothing else, if you decide there is one lifestyle change you will make to avoid cancer and improve your health, make it this: give up sugar, in all its forms, in anything" (p. 244)


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 Posted 12/16/2013 5:22:38 AM
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There is a lot of anecdotal evidence concerning the benefits of giving up sugar.  Have heard reports of significant weight loss, arthritis disappearing, and more with just this one change.

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 Posted 2/22/2014 9:53:42 AM
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Check out the book "Cancer as a Metabolic Disease".  A good read.  The PhD researcher recommends a restricted ketogenic diet of 500-700 Cal with 65% Fat, 30% Protein, 5% Carb and reducing BG to 55-65 mg/dL.   Once the metabolism changes to fat burning he has strong evidence that the normal cells become stronger and the cancer cells being weakened are consumed for useful inputs. He has repeatable results using the mouse model and anecdotal with humans.  All the science is explained.   He also has refuted the claim that cancer is driven primarily by DNA by a repeatable test replacing a mouse's healthy cell with a cancerous nucleus resulting in no cancer, and then replacing a cancerous cell's nucleus with a healthy nucleus resulting in continued cancer.   He argues persuasively that cancer is primarily due to mitochondria dysfunction and secondarily augmented by DNA.

Before my surgery, to get my BG to 62 mg/dL I had to restrict carbs to 5 grams per day and bump fat to 80%.   A therapeutic fast of 4-7 days with only water kick starts the keto process.
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 Posted 2/22/2014 9:55:37 AM
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I should add: the body will convert protein to glucose.  This is why I had to drastically reduce protein from the standard ketogenic ratios to achieve a BG of 62 mg/dL.
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 Posted 2/23/2014 12:50:18 AM
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Thank you Dan. Good point.

The book:
http://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/ref=sr_1_1?ie=UTF8&qid=1393149989&sr=8-1&keywords=cancer+metabolic

and a related article:
http://www.medscape.com/viewarticle/719423

Ketogenic diet reduces glycolisis. "Malignant rapidly growing tumor cells typically have glycolytic rates that are up to 200 times higher than those of their normal tissues of origin. This phenomenon was first described in 1930 by Otto Warburg and is referred to as the Warburg effect. The Warburg hypothesis claims that cancer is primarily caused by dysfunctionality in mitochondrial metabolism, rather than because of uncontrolled growth of cells. A number of theories have been advanced to explain the Warburg effect. One such theory suggests that the increased glycolysis is a normal protective process of the body and that malignant change could be primarily caused by energy metabolism.[15]"
http://en.wikipedia.org/wiki/Glycolysis

The most common glycolisis glucose breakdown path is the Embden–Meyerhof pathway (anaerobic, next to Kreb cycle which is aerobic) and I have read (X. Williams) that you can test (e.g. American Metabolics) an enzyme (PHI=phosphohexose isomerase). If PHI is high mitochondria are not working optimally and even more you need to eliminate sugar, increase B-vitamins etc.. I would also add PQQ which I will.


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