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My blood test results. Are they in-line with LEF guidelines?

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 Posted 7/9/2013 4:37:53 PM
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If you look at LEFs Optimal range of 20-25 for Free T, it's at the high end of the value range across age brackets, so I think they're saying keep it at the high end of the range. Also note that their range is listed based on 'Direct' measurement and I believe yours is calculated, so your number may not necessarily apply to their range. If you look at the article I mention, you'll see that Total T stays relatively flat until > age 55, but Free T is highest from ages 25-34 then drops each subsequent period corresponding with an increase in SHBG each. So as I'm sure you know, SHBG is binding Free T and LEF wants you to keep Free T at the upper end and not drop as you get older. I didn't see Estradiol in your labs, so you may want to have a look at that and DHEA-S too. So as to your final question, the idea of keeping a man's testosterone at the level of a 20-something was probably postulated as common sense. One generally feels their best in their 20s, recovers quickly from injury, has lots of stamina, etc, etc, so who wouldn't want to keep up those good feelings?

As an aside, I've read your "case against dietary fats" link, but I have to tell you that fish oil does wonders for my cholesterol. There is also a theory that high cholesterol is caused by hypothyroidism and TSH isn't the best indicator. And perhaps consider getting the VAP cholesterol test or at least test for LP(a). Sorry for rambling. Thanks for sharing your testing and for the questions. I think that is helpful to everyone. 
Post #9466
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 Posted 7/9/2013 10:20:06 PM
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Don,

Thanks for the correspondence I appreciate it. Sometimes the forum get so quiet I can hear crickets chirping. Lots of reader but few participants.

Explain to me the difference between direct measurement and calculated free testosterone.

I did't test for Estradiol oe DHEA because I was trying to keep it as simple as possible, as It can be a bit overwhelming. 

to answer your question about testosterone and twenty something, I think there's a lot more going on in a young person biologically other than just hormones. For example the brain isn't fully developed so a young man is more  impulsive, and quick to temper, etc., his body is just naturally younger and more flexible, so I think testosterone and hormones in general is probably just one factor that makes a young man feel like a young man.

My last answer is a good segway to answer your question about my thesis concerning dietary fats. I think main thing that keeps us feeling young, vibrant, and strong, is the integrity of our cells. As we age we are exposed to more toxins, for example from the food that we eat, or the lack of food thereof, vices, stress,, lack of sleep, and a myriad of other things. A young person has less exposure to those things just by the mere fact that they have less years on this earth. Additionally, cells only have a certain amount of times they can divide before they die. As we age, more cells are entering their end of life.

Fats or lipids are the most unstable molecules. When the processed heated or otherwise altered, there is a greater chance for these molecules to become degraded, and become toxic to cells. The problem with dietary, processed fats is that it's very hard to tell the quality all times, especially if they are encapsulated. One may be subjecting themselves to  more harm than good to cells. This could also depend upon the quality choosen, but not necessariy. It all comes down to risk vs benefits for each individual. If fish oils are helping you then it's a choice you have to make whether the potential risk is worth the benefit or vice versa. its very parallel to people who use marijuana to ease their chronic pain. Excessive marijuana use has been shown to damage cells of the brain and the inhalation of smoke damaging cells of the lungs. However, they have chosen that the risk is worth a greater benefit.

-Tom

P.S.  My total and LDL cholesterol is high due to incorrect dietay choices all last year, as I got off track. Getting diet back on track will correct this.


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 Posted 7/11/2013 3:52:12 AM
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Tom, you should do the VAP test to see what kind of LDL you have.  Also, it's always a good idea to check estradiol; in many cases, treating high estradio enables one to restore proper testosterone levels.
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 Posted 7/11/2013 3:52:15 AM
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Tom, your free T looks calculated (vs directly measured as per Don's link): you get exactly your 36.4 pg/mL by input albumin and SHBG in the standard evaluator given in Donatello's link: http://www.issam.ch/freetesto.htm or also: http://www.nebido.com/tools/index.php/en/default/index/free-calculator.
In my tests the standard way I am offered in Switzerland is the calculated one, while I got a couple of direct measurements in US (LabCorp). Of course, depending on the Lab and methods used the ref. ranges change. I got mad making sense of these numbers. Normal GP do not tell you much on hormone levels and balancing and AA doctors are very expensive to consult with. I settled down for the time being to try to look at trends along years, and try to target the high range of the ref range given by my own lab which I keep constant. From one lab to another one you can also try to extrapolate. I only once tried to supplement with testosterone cream to check but of course I am very cautious due to my prostate condition as many in this forum are now aware. There is also the salivary vs blood test "schools" but I prefer to look at blood tests. Your PSA looks very good, so I personally do not see a problem in a course of TRT and see how you feel: normally the doctor should have asked about symptoms of testosterone deficiency and not only look at the numbers. Should you decide to go for TRT of course do it with her/him, e.g. she/he should look also again at any change on PSA and how the DHT and E2 level are modified by the activity of your 5-alpha reductase and aromatase enzymes respectively.


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 Posted 7/12/2013 7:51:09 AM
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What will a VAP test will reveal? What are the types of LDL and why would this be important to know?

Yes I should probably have my E2 and dht tested. If it was found that dht was high I would not want to take finasteride to block conversion as that has serious side effects. If E2 was high than probably the course of action would be anastrozole once or twice a week.  Any side effects with males using that?

I've been taking the bio30 New Zealand propolis which has CAPE, which has been demonstrated to kill prostate cancer cells. So maybe it's been working to keep it away, and perhaps why my PSA is low.  I've also consumed a very good diet all my life up until last year.

-Tom.


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 Posted 7/13/2013 4:05:46 AM
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The VAP test measures the density of LDL.  Low density is good; high density is bad.  So if your LDL is low density, then no problem.
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 Posted 7/13/2013 8:08:59 AM
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http://www.lef.org/magazine/mag2007/may2007_report_vap_01.htm

"LDL Size Pattern: LDL particles vary in size, ranging from small, dense “Pattern B” particles to large, buoyant “Pattern A” particles. Smaller LDL particles are associated with an increased risk for heart disease. Small, dense LDL (“Pattern B”) is associated with insulin resistance or diabetes."

Off the subject a bit, this got me thinking.. Homoginized whole milk is forced with pressure through a screen that transforms the fat globules from large to tiny to prevent seperation of the cream (fat).  I wonder if consuming homoginized,  whole milk contributes to heart disease, versus  raw, unhomoginized milk. I wonder if drinkers of homoginized milk have 'Pattern B' LDL?

Just a thought.

-Tom.

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 Posted 7/14/2013 2:19:46 AM
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I wonder if consuming homoginized,  whole milk contributes to heart disease, versus  raw, unhomoginized milk. I wonder if drinkers of homoginized milk have 'Pattern B' LDL?

Not true for me. I consume ~0.5l organic, full fat homogenized UHT milk a day (in the form of home-made yogurt and with my coffee) for several years and have moderate, A-pattern LDL (last test was 100mg/dl) as well as high HDL (56) and low triglycerides (87). I wouldn't expect it to have any ill-effect, beacuse the amount of cholesterol even in large quantities of full fat milk is minuscule compared to to body's own pool and only a fraction of that is absorbed. I think all those worries regarding homegenization and heat treatment of milk are largely unfounded. Everyone agrees that yogurt is a particular healthy form of milk - especially those who demonize UHT milk. Ironically though, they forget that for the production of yogurt milk always has to be cooked and sterilized, just like UHT milk. I buy UHT milk so that I can skip that step.
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 Posted 7/14/2013 8:03:17 AM
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Good to know Timar, 
Thanks

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 Posted 7/17/2013 1:15:09 PM
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When testing estradiol,  should I test for free and total, or one or the other?.  Is it necessary to also test amortarase to see if levels are high causing conversion, or not necessary? Thanks 
-Tom

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Post #9544
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