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Asperger's Syndrome

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 Posted 6/19/2013 11:54:11 AM
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I haven't been officially diagnosed, since I didn't see any need to do so and I dislike psychiatrists, but quite a few people have claimed that I have it. Reading over the symptom list it appears they are probably correct. Also according to the DSM-V it no longer exists as a diagnosis.

I'm not sure how much of my increased nutrient needs are due to 'aspergers' since they don't actually know what causes it. In my case it appears I need much more than standard amounts of: pyridoxal phosphate (B6), methylfolate (B9), methylcobalamin (B12), chromium, manganese, choline, and probably niacin. I'm still in the process of verifying niacin. I do frequent blood testing via various LEF (cbc, aminos, etc), Doctor's Data (whole/rbc minerals), and SpectraCell (MNT) tests. I'll probably add a fatty acid blood test sometime soon to make sure there isn't any weirdness there as well.

Also I would not recommend megadosing nutrients without testing as everyone is different. For example, I currently need 30mg/day of manganese (UL is 11mg) to balance the blood test but my wife only needs 12mg/day.
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 Posted 6/21/2013 6:08:40 AM
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Yes, my carnitine blood level is definitely weird also. I've taken between 500mg-1500mg over the past few years and the total and free carnitine levels are always above range, even when the ratio is too high (acyl/free). I think it might be related to niacin/adiponectin levels but I'm still working on that angle.

Needing as much manganese as I do may also indicate mitochondria issues as its used for SOD2.
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 Posted 6/22/2013 2:40:41 PM
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My lithium level on the DD hair elements test came back undetectably low and after doing the DD blood mineral tests I found I need about 1.25mg/day, 1/4 of a 5mg pill, of lithium to balance the blood test. I haven't done a follow up hair test yet to see if it normalized that level as well. I've managed to balance all the rbc minerals tested according to the DD test except for chromium. RBC Chromium appears to not improve despite much increased intake (1200mcg/day), possibly due to interaction of low adiponectin and gtf. It also takes around 1300mcg/day of Iodine to to bring my serum blood level to center of normal. Though I'm not sure if these are final numbers since my bh4 level still seems low from looking at my amino panel, high tryptophan, upside down phenylalanine/tyrosine ratio, etc. Methylfolate seems to be helping improve those stats, which may influence the need for other nutrients. I'm currently at 2400mcg/day of methylfolate but it seems like it might still be low, I may eventually need to get a prescription for Deplin which is high dose methylfolate. Unfortunately determining if things like the niacin metabolites NADH, NADPH are low is hard since there aren't direct tests for them. Taking more niacin also puts a strain on methylation, which may already be low to begin with, so you have to be careful to balance everything.

I'm not really sure what my biotin status is, SpectraCell MNT claims its fine but I've come to suspect the MNT isn't that useful in the cases of genetic issues preventing activation of vitamins. As I understand it they just add additional vitamins to the wbc to see if it improves growth, in cases of genetic issues though this would not help much if at all. For similar reasons directly measuring serum/whole blood vitamin status may also be less than useful except in cases of gross deficiency. Measuring indirect factors like figlu, mma, and aminos may be more useful in determining effective deficiency.

Sorry for the long post, hopefully it wasn't too rambling.
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 Posted 6/23/2013 3:11:44 AM
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Inositol, in high doses, is known to help individuals with autism and Asperger's.  I've known people with Asperger's, so I'm a bit surprised that the APA has taken this out of the DSM.
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 Posted 6/23/2013 5:23:54 AM
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Carl, while this does not reply to your supplementation question, it might be interesting when looking at genotype:
"Association of DISC1 with autism and Asperger syndrome"
http://www.nature.com/mp/journal/v13/n2/full/4002031a.html
http://www.nature.com/mp/journal/v13/n2/fig_tab/4002031t1.html


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