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 Posted 6/9/2013 9:18:08 PM
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Post #9199
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 Posted 6/10/2013 4:11:41 AM
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Leftist garbage, as would be expected from the New York Slimes.  The AMA is in cahoots with pharmaceuticals.  There are thousands of studies which refute everything in this pathetic article.  I read Investor's Business Daily, the only decent newspaper left in the country.
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 Posted 6/10/2013 6:20:50 AM
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In my opinion mega-dosing continually outside the context of disease therapy is unnatural and may be harmful.

We know potential risks exist. For example; chronic intake of synthetic vitamin A and pseudotumor cerebri. Vitamin A deficiency is rare in industrialized nations but many multivitamins contain 10,000 IU of retinyl palmitate (the upper safe limit).  Excess vitamin D and hypercalcemia and hypertension. Overexpressed growth hormone (HGH injections) and carcinogenesis, and the latest news concerning excess B's and neuropathy. As I've pointed out in my thesis (see link in my signature line) the potential genotoxic, and cytotoxic properties of processed/molested lipids.

To date no large-scale, life-long, epidemiological studies exist that prove nor disprove synthetic vitamins can extend life past the expected mortality table (70-100 chronological years, respectively). Nor has such a study taken place to determine if biological complications from life-long mega-dosages may or may not ensue.

On the other hand, relatively moderate, short-term, and noteworthy scientific studies, and anecdotal evidence exists that supports positive outcomes regarding certain supplements. Examples that come to mind include; Vitamin C for viruses, glucosamine for joints, lutein for ocular health, etc.

That said, each person must do their own research and determine what is best for them.  

-Tom.


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Post #9202
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 Posted 6/10/2013 11:27:17 AM
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I haven't had time to locate each of the studies that the author cites; have only just located the first one, here, which interested readers should review:

http://www.nejm.org/doi/full/10.1056/NEJM199404143301501

That study actually reports a mix of results both good and bad and the opinion writer (who should know better) chose only to report the bad. The good results were not supportive of his thesis, so were ignored. This appears to be a case of starting with a conclusion and selecting the facts needed to support it - and ignoring any that don't fit.

It wasn't hard to find a later study that shows a decrease in mortality using a slightly different regime that included vitamin C and an older cohort:
http://www.sciencedaily.com/releases/2009/02/090214084823.htm

If Dr. Offit had been more objective in his analysis and opinion, I suspect his piece probably wouldn't have gotten much attention or even been published (not newsworthy.) I'm not sure whether this is a case of starting with an outrageous thesis to garner attention to make a reasonable public alert (i.e. be careful of claims made by supplement makers and sellers) and then back-tracking once the attention is had, or whether the doctor is acting disingenuously or has some sort of self-serving motivation.
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 Posted 6/10/2013 2:48:57 PM
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Members of Life Extension seek to take the optimal amount and kind of supplements to prolong health and longevity.  We constantly test our protocols and revise them as necessary.  You are in charge of your own life, and therefore you have to experiment with what works best for you. There is a tremendous scientific literature on supplements--read each and every article in Life Extension magazine and look at the references! And stop listening to the nonsense of the New England Journal of Medicine--they just want you to pay doctors for prescriptions--which are, actually, poisons (sometimes necessary, but usually not).  Always try natural compounds first.
Post #9205
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 Posted 6/12/2013 6:39:55 AM
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 Posted 6/12/2013 8:17:17 PM
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Perhaps the case then can be made that antioxidants are best taken in cycles during a course, letting the body absorb/excrete and benefit from them, then cycling off?  Say, for instance, heavy doses one day/lesser doses another, or perhaps not taking any antioxidants at night in a diurnal cycle?

Personally, I'm thinking of reducing my antioxidant intake on fasting days and upping the intake on meal days in a cyclic fashion.
While the benefits of antioxidants are indisputable, Dr. Offit may not be entirely wrong either.  Mega-dosing on vitamins and antioxidants can't be both entirely beneficial AND dangerous.
Plenty of evidence seems to say some forms of vitamins are more beneficial and safer than others and time and dosing schedules may play a big role.  Wasn't there a study a few years back that showed high doses of melatonin being harmful to the eyes in the presence of bright light so melatonin only to be taken at night (but who would take large doses of melatonin while trying to stay awake I wonder) . . . and another study that showed resveratrol showing reduction in any benefits if taken at night rather than during the day? . . . and yet another study that showed taking vitamin C before exercise reducing the adaptation benefits of exercise? Or studies showing that excess carotenoids can limit the power to fight infections?  Anyone else recognize any of this?  I'll take the time to look more of this up later, just some thoughts before heading to bed. . .



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 Posted 6/13/2013 4:46:38 AM
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Anything has potential unwanted effects and upper tolerable limits, including oxygen and water.  And yes, care should be taken when consuming supplements and new knowledge incorporated into one's regimens when it comes to light. 

The results of one study on a particular subject are not considered sufficient evidence to establish a fact, but can point one in a direction in which additional research can be conducted to verify a particular hypothesis.  There have been tens of thousands of studies that have shown benefits for nutritional supplementation, elevated blood levels of nutrients, or diets that contain higher than average amounts of a particular nutrient.  Studies with negative findings are a minority, yet if these findings are confirmed, one shouldn't fall into the error of all or nothing thinking, i.e., that nutritional supplementation is harmful.

We often hear that one can get all the vitamins and minerals one needs from food.  With an ideal diet one may get all the nutrients one "needs," for survival to an average age if one is not unfortunate enough to have a genetic propensity toward a particular disease or is exposed to one, or is injured in some way.  Many of us would like to go beyond the limits of nature and achieve optimal health and longevity.  As the alchemists of old said, "Nature unaided always fails."  It is up to the human brain to find a way to enable humans to change the limits nature has imposed on human life span.  Nutritional supplements may not enable humans to exceed what is considered maximum life span (age 122) but may help more people achieve a longer life span in good health.  And people are free to disagree and not use them.

Roger Williams, PhD, in his book Nutrition and Disease wrote " . . . in nature, yeast cells are always hampered by inadequate environment and imperfect nutrition.  Otherwise, they would have engulfed the earth long ago.

Brief reflection gives rise to the conclusion that imperfect nutriton must have been the universal rule for single-celled creatures ever since life began on earth. 

How about human beings?  Are they apart from all the rest of nature in this respect? 

Do all the cells in our bodies always get an optimal assortment of all the nutrients--minerals, amino acids, and vitamins--that they need?"

Williams, Roger. Nutrition Against Disease. Bantam (New York) 1973; p 27-28.

Copyright laws prohibit me from including more, but this scientist, who discovered vitamin B5, presents the case for supplementation perfectly.  We really don't know what the human being is capable of in terms of optimal health because we've never had optimal nutrition and are still finding out what it is.  At the same time, overnutrition in terms of calories is a sure path to a reduction in years lived and optimal health.


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 Posted 6/13/2013 6:01:19 AM
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One must also not forget spiritual nourishment and sustenance.  A strong body cannot sustain with weak spirit. The mind is the conductor and the body the instrument, and together in harmony beautiful music is made.

-Tom.


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Seize every opportunity to put your best foot forward.

Anything worth doing is worth doing well.
If you don't stand for something, you will fall for anything
If everything seems under control you're just not going fast enough. - Mario Andretti
You can't expect to do business today, with yesterday's tools, and be in business tomorrow. - Author Unknown
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The case against dietary fats >>  CLICK HERE
Post #9226
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 Posted 6/13/2013 7:12:01 AM
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My 82 year boss has been on different drugs and no vitamin/mineral supplements for years for her various ailments.

She is now very tired with no energy and in pain most of the time.

So those that believe this article will safe a lot of money but probably end up suffering  like my boss.
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