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Curcumin - Inflammation - Cancer

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 Posted 3/28/2013 4:58:01 AM
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There are a lot of studies on curcumin role in cancer chemio prevention. The following (in vivo, 2012) study adds to the positive stack. As usual, there are also counterbalancing studies too (I posted elsewhere and can find that back) but feel the balance might shift one day in favor of curcumin due to the increasing evidence of the inflammation - cancer link and the role of curcumin to reduce inflammation.

Maybe curcumin's role, as well as other substances, in mitigating metastasis, is important when considering that we all likely have pre- or cancerous cells in our bodies.

I do not have full access to the full study (and time to do). I just wonder about dosage and/or means to increase absorption in the study, in case you have the info.

Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2
"... We show that Curcumin inhibits translocation of NFκB to the nucleus through the inhibition of the IκB-kinase, IKKβ, leading to stabilization of the inhibitor of NFκB, IκBα, in PC3 prostate carcinoma cells...

... chronic inflammation can induce a metastasis prone phenotype in prostate cancer cells by maintaining a positive pro-inflammatory and pro-metastatic feed-back loop between NFκB and CXCL1/-2. Curcumin disrupts this feed-back loop by the inhibition of NFκB signalling leading to reduced metastasis formation in vivo...."

http://carcin.oxfordjournals.org/content/early/2012/10/01/carcin.bgs312.abstract


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 Posted 3/29/2013 9:51:05 PM
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 Posted 10/7/2013 4:42:07 AM
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 Posted 10/19/2013 8:25:39 AM
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Interesting Sameer! I do not realize the link to curcumin though.
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 Posted 10/19/2013 4:09:39 PM
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There is no link.  I certainly hope we are not getting spammed.
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 Posted 10/20/2013 12:47:51 AM
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DDye (10/19/2013)
There is no link.  I certainly hope we are not getting spammed.

Good point DDye, I am afraid we are.
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 Posted 1/17/2014 6:55:05 AM
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I am sorry to duplicate entirely this update from LEF but I found it interesting. This in-vitro effect of curcumin is known since sometime and it keeps being confirmed. Moreover, prevention should prime and go along with treatment.

Curcumin sensitizes colon cancer cells to chemotherapy

http://www.lef.org/ezine/art09_04_17.jpg

Friday, January 17, 2014. An article published in the journal PLOS One reports the finding of Mehdi Shakibaei of Ludwig Maximilian University in Munich, Germany and colleagues of a chemosensitizing benefit for curcumin, a compound occurring in turmeric, in colon cancer cells resistant to treatment with the chemotherapy drug 5-fluorouracil (5-FU). Resistance to 5-FU occurs in as many as 15% of colorectal cancer patients, and the rate of recurrence is estimated to be as great as 50% to 60%, due in part to cancer stem cell survival.

The current study utilized cultures of two high density colorectal cell lines that were sensitive to 5-fluorouracil and cultures of their 5-FU resistant clones. One of the two non-resistant lines and its resistant clone were deficient in their DNA mismatch repair (MMR) systems, which results in genetic instability, increased susceptibility to neoplastic transformation and greater development of chemoresistant cells. Cells were treated with varying concentrations of 5-FU or BCM-95 curcumin, or received pretreatment with curcumin followed by exposure to one of four concentrations of 5-FU.

While 5-FU dose-dependently reduced the proliferation of the non-resistant cell lines, curcumin alone decreased proliferation in all cell lines, showing the most significant effects in the lines that were not MMR-deficient. Pretreatment with curcumin four hours prior to 5-FU administration revealed a benefit in 5-FU sensitive as well as resistant cells after 24 hours. Either treatment or their combination also decreased markers of cancer stem cells in all lines, with the greatest benefit observed in association with combination therapy.

"Our results demonstrate that with curcumin the proliferation of MMR-deficient and proficient colorectal cancer cells as well as their corresponding 5-FU resistant derivatives was suppressed and the effect of 5-FU was potentiated in a dose-dependent manner, thereby reducing the proliferation of colorectal cancer cells significantly," the authors write. "We demonstrate that curcumin potentiated the antitumor effects of 5-FU in the parental as well as the 5-FU resistant derivatives of these cells in a three dimensional high density environment resembling the in vivo situation."

"In this report, we provide novel evidence and previously unrecognized effects of curcumin, showing that curcumin individually or in combination with the conventional colon cancer chemotherapeutic agent 5-FU could serve as an effective therapeutic strategy to prevent the emergence of chemoresistant colon cancer cells by reducing cancer stem cells," they conclude. "Our data suggest that a combination treatment of phytochemicals together with conventional chemotherapeutic agents can be very beneficial for the patients in enhancing the clinical therapy and simultaneously reducing side effects through lower dosage requirements."

Source is HERE.



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