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 Posted 3/16/2014 3:14:28 PM
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Phase 3 of a new cream to control the mites but..................The latest thinking regarding the pathogenesis of rosacea is that this common chronic inflammatory skin disease is not caused by demodex mites, Propionibacterium acnes, or any other pathogen, she explained. In the current concept, cathelicidin proteins that are present in the epidermis as part of the vanguard of the innate immune system play a key role. When these proteins detect a foreign invader on the skin – bacterial, viral, or fungal – they release toxic enzymes, including cathelicidin LL-37, which kill the offending organism. High levels of LL-37 are proinflammatory, angiogenic, and activate the acquired immune system, effects that would explain the chronic skin redness and telangiectasias of rosacea. The trouble is, demodex is not a foreign invader.

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 Posted 3/19/2014 7:22:28 PM
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I'll ask the derm doc when I finally get to see him in a few weeks.

The demodex mites may be a foreign invader because they don't exist on human skin until around age 10. We are not born with them so they are acquired. The cathelicidin LL-37 angle is interesting as well. There may not be one rosacea. Some dermatologists feel there may be 3 or 4 separate and independent causes that manifest with the same symptoms. That is what makes it so hard to fix.

The honest answer is they just don't know. This is one they haven't figured out yet. All I can say is the tea tree oil and topical antibiotic worked for me. Still a bit pink but it's the best it's been in 2+ years.
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 Posted 3/20/2014 4:57:11 AM
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Rosacea seems to be associated with SIBO.

Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication.  -Pubmed



CONCLUSIONS:

This study demonstrated that rosacea patients have a significantly higher SIBO prevalence than controls. Moreover, eradication of SIBO induced an almost complete regression of their cutaneous lesions and maintained this excellent result for at least 9 months.



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 Posted 3/26/2014 9:29:53 AM
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Tim1361, congratulations with your positive progress. I never heard about mites before, good to know about this. I also have problematic skin on face. Few years ago I started noticing first small red spots on my face. Initially I didn't pay much attention but later I realize it might be not just temporary face redness but something more serious. I don't know if it's exactly rosacea but I started looking for ways to improve my skin condition naturally at home. I found various recommendations in the Internet, for example this list of tips is very simple and easy to follow. After a while I started noticing small improvements. But it took ages. I got better results once I tried different cremes. Finally I found out that Revitol rosacea cream worked the best for me. I'm using it regularly for about 3 moths.

I think I stated helping my skin relatively on early stage so I managed to get control over face redness. I still can't say I cured it completely but my face is much cleaner now.


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 Posted 3/26/2014 7:38:02 PM
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That is very interesting. Thanks for the pubmed link. Finding things on that site can be fun.

I wonder if that is why some people have reported eating raw garlic helped? Eliminating dairy (lactose? casein?) has also been reported to help some. Different ways to curb SIBO? Hmmmm.

I know the antibiotic my doctor gave me didn't do much. Perhaps it was the wrong antibiotic. He said it was the same one they used for h-pylori ulcer treatment as h-pylori is also implicated in some rosacea cases.

Good progress and hopefully others will find what they need quicker than the 2+ years it took me.

Cheers
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 Posted 3/27/2014 11:02:33 AM
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I assume the problem with antibiotics that don't work is because it's very difficult to identify the exact root cause of rosacea and as a result prescribe the treatment that will bet the most efficient. As I understood the real causes of rosacea are not really known and official medicine has only a list of most likely factors...
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