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Vitamin D2 in Two-Per-Day Tablets

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mef
 Posted 9/12/2012 7:45:34 AM
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Hi,

I was wondering why 2000 IUs of Vitamin D2 (as ergocalciferol) are in the Two-Per-Day Tablets, instead of the recommended D3 variant. I am already taking D3 separately, and it seems to me it would be more convenient to have the Vitamin D3 as part of the Two-Per-Day Tablets.

What is the reason for choosing D2 vs D3? What is the recommendation for D3 intake for Two-Per-Day Tablets users that also get D2?

Thanks,

Post #7063
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 Posted 9/12/2012 7:50:33 AM
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Welcome to the Forums, Marco.

Vitamin D2 is in Two Per Day in keeping with the product's vegetarian formulation.  (Vitamin D3 is derived from wool.)

D Dye
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mef
 Posted 9/12/2012 8:09:19 AM
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Hi,

there is some literature out there that supports the use of D3 vs D2:

Conclusion:D3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2. For neither was there evidence of sequestration in fat, as had been postulated for doses in this range. Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency.

http://jcem.endojournals.org/content/96/3/E447.abstract

AND

The meta-analysis study was led by Professor Dr. Goran Bjelakovic.

Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Wetterslev J, Simonetti RG, Bjelakovic M, Gluud C. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD007470.

He analyzed 50 randomized controlled trials (RCTs) with a total of 94,000 participants that used some form of vitamin D and reported mortality rates as either primary or secondary outcomes. Within these RCTs, 32 of the studies used D3 (74,000 subjects) and 12 of them used D2 (18,000 subjects). He found there was a 6% relative risk reduction when supplementing with vitamin D3, as opposed to a 2% relative risk increase when supplementing with vitamin D2

http://blog.vitamindcouncil.org/2011/11/16/meta-analysis-looks-at-efficacy-of-d2-vs-d3/

Any comments on this point of view? Any recommendation on the intake of vitamin D2 when one also wants to get the allegedly more potent and beneficial D3 variant?

Thanks,

Marco


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 Posted 9/12/2012 9:00:05 AM
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mef,
You could switch to the Two-Per-Day capsules, they use D3 not D2.
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mef
 Posted 9/13/2012 6:19:35 AM
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Thanks, DDye and Ross for the clarification. I had not noticed that difference between tablets and capsules before.

Regards,

Marco
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