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high doses of vitamin D3

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 Posted 3/15/2013 5:16:11 AM
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Whiskey,

You are correct. Magnesium, manganese and potentially other mineral levels are all effected by Vitamin D intake.  I had problems getting enough manganese with high dose Vitamin D intake (10,000IU/day), even 50mg/day (21x RDA) wasn't enough. I reduced my Vitamin D intake to 5000IU and it looks like manganese at 30mg/day (13x RDA) should be enough for me for that level. My wife has similar issues as you with regards to very low magnesium levels even at 1200mg/day of magnesium citrate.

It's a good idea of course to test for levels and not just assume a particular mineral level is low. I test them every few months and adjust intake as necessary.
Post #8463
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 Posted 3/17/2013 1:42:09 PM
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I too have recently read Jeff Bowells book and while finding it very interesting I don't think I would supplement at the levels he did. But the fact that he did it does illustrate how safe it is for the average person to take at very high doses as long as they take K2.

My level at my last blood test was 38 ng/ml but since I am shooting for 50-80 ng/ml, I am currently supplementing with 10,000 IUs of D3 a day.

I can't help but wonder if my wife got her levels up higher if it would lower her high systolic blood pressure.
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 Posted 3/18/2013 5:35:58 AM
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Taking the topic verbatim I would caution against taking single doses of more than 100.000 IU. Look what this study found:

http://www.ncbi.nlm.nih.gov/pubmed/23052222

We investigated the short-term effects on bone turnover markers of high doses of vitamin D(3) in order to identify what initial therapeutic dose can be safely administered in vitamin D-deficient subjects. Thirty-seven elderly subjects [mean age 75 ± 3 (SD) years] were consecutively randomized to the administration of a single oral bolus of 600000, 300000, or 100000 IU vitamin D(3). Blood samples were taken at baseline and 1, 3, 7, 14, 30, 60, and 90 days after vitamin D(3) administration. Twenty-four subjects served as controls. No relevant changes in bone turnover markers [C-terminal telopeptides of type I collagen (sCTX) and bone-specific alkaline phosphatase (BAP)] were observed in the controls. In treated patients a dose-dependent effect on sCTX was observed. With the administration of 600,000 IU vitamin D(3) a significant increase of sCTX was observed already at day 1, and it was sustained for 2 months. The changes in sCTX with smaller doses were considerably lower and reached statistical significance only within the first 3 days with the 300,000 IU dose. BAP remained unchanged in patients given 300,000 and 600,000 IU vitamin D(3), while it significantly rose by 15-23 % throughout the observation period in patients given 100,000 IU. Our results indicate that the use of a vitamin D bolus exceeding 100,000 IU may be associated with acute increases of sCTX.
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 Posted 3/18/2013 4:38:35 PM
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I checked the site where many tried this big dose of vitamin D. They said they would report back but hardly any did. Report of results

One thing I noticed was mentioned in the book summary was the recommendation of adding more vitamin K2 in concert with more vitamin D.

There was a study, I don't have it off hand but it measured the vitamin k2 status after increasing the daily dose of vitamin D but not vitamin k2. The vitamin k2 levels had dropped down indicating that vitamin D introduced a mechanism that uses more K2.

I'm not sure but this could mean that using 8,000 IU of vitamin D could leave you short in vitamin k2 even if taking 300 mcg of MK-7. This still needs to be worked out but it would be nice to see 500 mcg mk-7 products on the market as this is not harmful and this much can be gotten in 50gm of natto on average.


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Post #8493
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 Posted 3/13/2014 10:11:27 AM
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Whiskey (3/15/2013)
My existing magnesium deficiency (which was quite severe and caused vitamin D resistance) worsened to very severe taking 5000 IU of vitamin D daily. I upped my dosage to 10 000 IU for a while but i could not raise my vitamin D levels.  A warning should be on all vitamin D supplements on the importance of magnesium when supplementing!

"Vitamin D, just like all other nutrients, works in harmony with several other nutrients to perform its many functions. Most importantly, vitamin D requires and 'uses up' magnesium to convert from supplements or sun into its active form in the blood. As such, it is a big mistake to simply take large doses of Vitamin D without taking the need for magnesium into consideration."

Know the importance of taking enough magnesium with your vitamin D:
http://www.naturalnews.com/029195_magnesium_vitamin_D.html

Vitamin D council - magnesium:

Thanks for the two links, I think I'm okay on the magnesium, but have concerns about the vitamin K requirements. I'm on the blood thinner (Warfarin) and I keep some vitamin K on hand in case I have a bleeding event. I take a 45mg pill and the bleeding stops within 30-60 minutes. But other than that, it defeats the purpose of the Warfarin.

However I know first hand how D3 supplements can help. My memory started improving when I started taking just 1000iu/day. After about a year I learned a little more about D3 and decided to up my dose to 5000+iu/day and now my memory is as good as it's ever been, and my ADHD symptoms have improved a great deal.

But then I read that you should take several things into consideration with your D3 supplementation, such as age (I'm over 55), weight (I'm way over 180 lbs) and I live in a Northern climate(Washington state). That's 3 strikes and the recommendation is to take 10,000iu/day which I started 4 weeks ago. I was tested last week and am still waiting for the results. I'm looking to be somewhere between 60-100 ng/ml. 




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 Posted 3/13/2014 11:45:47 AM
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calc (3/15/2013)
Whiskey,

You are correct. Magnesium, manganese and potentially other mineral levels are all effected by Vitamin D intake.  I had problems getting enough manganese with high dose Vitamin D intake (10,000IU/day), even 50mg/day (21x RDA) wasn't enough. I reduced my Vitamin D intake to 5000IU and it looks like manganese at 30mg/day (13x RDA) should be enough for me for that level. My wife has similar issues as you with regards to very low magnesium levels even at 1200mg/day of magnesium citrate.

It's a good idea of course to test for levels and not just assume a particular mineral level is low. I test them every few months and adjust intake as necessary.


Which test are you doing and which minerals are you getting results for?
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 Posted 3/13/2014 6:46:24 PM
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I got my test result when I called my doctor. It was 53 ng/ml. Not quite what I was hoping for, but that level could go up after I've been taking 10,000 iu/day longer that 3 weeks.
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