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Melatonin and Blood Sugar

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 Posted 8/1/2012 6:12:13 AM
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I've been having sleep issues for the past 5 years and my Doctor ordered a saliva cortisol test. When the results came in the graph showed my cortisol was lowest in the morning and the highest at night. Reverse of what they should be. 

My Doc told me to take 6 mg of melatonin 30 minutes before bed which I did. The only problem occurred the next morning when i checked my fasting blood sugar level. It was 125 which is about 25 points higher than my norm. 

I continued for 2 more weeks with the melatonin but each morning my blood sugar level is 20 to 30 points higher than usual. So I am going to stop taking it tonight. Has anyone else experienced this problem ?

Any recommendations on lowering cortisol at night naturally...    
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 Posted 8/3/2012 6:22:34 AM
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A couple of years ago when I was having trouble sleeping because of a stressful situation I got into the habit of taking high dose melatonin (over 10 mg per night).  During the past year I started monitoring my glucose level and found that my fasting glucose in the morning was very high, usually 115 or higher.  My doctor prescribed Metformin,  and I also tried various supplements that supposedly lower blood glucose, but nothing worked. 

Both yesterday and today my morning fasting glucose reading was below 90, and it just happens that I had reduced my melatonin to 4.5 mg.  If I hadn't seen your post I would not have made the connection.  I will now test reducing the melatonin further and see what happens.  It would be amazing if it turns out that the melatonin was raising my blood sugar that much.

This is a subject worthy of study.
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 Posted 8/3/2012 6:26:56 AM
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Welcome to the Forums.

Have used melatonin nightly for years and have had a number of a.m. fasting blood glucose tests which have all been normal or low.  Nevertheless, we are all biochemically unique and perhaps there is a connection, or it may be coincidence.

D Dye
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 Posted 8/3/2012 7:21:29 AM
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How much melatonin have you been taking?  If it raises glucose it may only happen at higher doses.  It would be nice to see a trial with people taking different dosages.
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 Posted 8/3/2012 9:08:39 AM
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My dose is 500 mcg.

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 Posted 8/3/2012 10:00:35 AM
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I have been taking 3 mg daily of melatonin for over 15 years with no effect
at all on my blood sugar.
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 Posted 8/3/2012 4:32:48 PM
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The first night I didn't take melatonin (6 mg) my blood sugar returned to my normal fasting level which is about 98 - 102. The melatonin had spiked my fasting blood sugar at least 25 points each of the 2 weeks I took it. Tomz, glad to see I wasn't the only person with this issue. 
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 Posted 8/3/2012 5:33:49 PM
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I'm not certain but from what I see searching online it appears niacin can sometimes increase blood glucose levels. If you take enough melatonin it may cause your body to shift tryptophan metabolism over to more niacin production which might be the cause for the higher glucose levels some of you see.
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 Posted 8/4/2012 3:51:27 AM
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My dose is 1 mg, sublingual.  I think 6 mg may be too high for you....
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