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IP-6 inositol hexaphosphate

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 Posted 3/29/2014 2:54:55 AM
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Trans, I am taking THIS.

Post #12415
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 Posted 4/1/2014 7:39:52 AM
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Welcome to the Forums, FB.

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 Posted 4/1/2014 8:10:32 AM


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Not sure if this is the right place to message you about this, I did try your pm but it doesn’t work for me.

Could you please shed some light? I have recently discovered I have too much iron and wanted to know more about how to use IP6.Do you know how much iron is being removed and by what dosage? An average, less than, more than? 

I’ve been taking IP6 (Inositol hexaphospateand inositol 1,020 mg mixed with 100 mg calcium, 145 mg phosphorus, and 30 mg magnesium, which are part of the supplement) to help with the oxidation process,but never realised it could remove iron from the blood. Do you think this is a good combination and could you tell me what you are using please?

Also, I would be interested to know what other supplements and antioxidants help with too much iron, would it be ok for you to make some suggestions? I’m new this problem and am finding that there’s a great deal to understand. 

I have also been taking 500 mg vitamin Cwhen (if) I wake up in the middle of the night, initially to help boost my immune system, but then realised it chealates iron. I have started researching to understand if this is a good idea or not when I found your post. Do you know if it’s safe to take vitamin c in this way? I thought it might be ok as it’s so far away from food, but not sure if there are other reasons I shouldn’t betaking it (apart from helping to absorb more iron from food).

Any help you can give me is very much appreciated.

Post #12462
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 Posted 4/1/2014 8:49:42 AM


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Funnybone, from everything I've read and understand, vitamin C is a factor with iron absorption in the gut.
Alcohol is another thing that increases iron absorption in the gut.
For healthy people, absorption is probably the biggest issue when it comes to iron,  because typical diets contain at least 20 times the amount of iron your body actually needs, but so very little of it actually gets absorbed.  Some experts suggest eating less meat, less alcohol, and less vitamin C when iron stores are excessive.

The body more readily absorbs iron from meat than plant sources (many plant food stuffs also contain a bit of IP6 which blocks some mineral absorption --but that is  another matter entirely, since most advocating IP6 around here suggest taking it separate from an actual meal).
When I found-out that my blood was too high in iron about ten years ago, I immediately ceased iron-fortified foods and stopped with all supplements containing iron, switched to a more plant-based diet, then I dutifully started donating blood every chance the blood bank allowed me to do it, it took about 4 or 5 years of this to achieve healthy ferritin levels.
Right now, my body is in the fortunate state of having optimized ferritin iron levels hovering just barely below 50ng/mL, but this comes with a new burden of needing to be careful about iron stores in the other direction. The danger of anemia comes into play at levels below about 20 ng/mL, but long before that there are negative side-effects of going below 50 ng/mL: the worst is that you are actually making your cardiovascular system less efficient by not having adequate iron, but more noticeably is that some forms of hair loss can be a possible side-effect.


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 Posted 4/1/2014 6:07:30 PM


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Hi Funnybone, & welcome!  You've come to the right place.

Congratulations on discovering your iron elevation...  Doctors don't routinely test for this and many are oblivious to the dangers they face from chronically elevated iron.  

IP6 supplements often state they "contain" calcium, phosphorous and magnesium, because these minerals are bound-up by IP6 to provide these minerals for the seedling.  Humans are not supposed to be able to break down the IP6 to provide these minerals in a usable form, and in fact, IP6 will attract and bind additional (but trivial) amounts of these minerals in human plasma.  If additional free minerals are actually added to the IP6 supplement, the IP6 will quickly get loaded up with these added minerals and won't chelate too much iron.  

IP6, when taken alone on an empty stomach quickly enters the body intact and binds free/serum iron in blood plasma, but does not affect iron bound to proteins like hemoglobin or ferritin.  Never take IP6 with food, as it will bind important dietary minerals in the gut, but will get too loaded up with these to pick up free iron in blood plasma.

When plasma iron falls, due to ingestion of IP6, the body will break down ferritin (stored iron) to keep up with demand for iron to build red blood cells and over time, stored iron/ferritin should also fall.  

A single blood donation will remove more iron than IP6 will chelate over several months, but be warned...  The needle they use at the blood bank is a BIG one!  About the size of a pencil lead.  It has to be, or it would take forever to drain off a pint.  If you do donate blood, donate only "whole blood".  Not plasma or platelets.  The iron is in the red blood cells!  Good hydration is the key to a happy donation experience.  Never go to the blood bank in the morning (when most are fairly dehydrated), but a couple of hours after lunch.  Drink water within the hour before you donate, and afterwords in the canteen before you leave.  

Vitamin-C will increase iron absorption from dietary sources if taken with meals...  Vitamin-C taken on an empty stomach is a good thing though!  Drinking Tea and Coffee with meals will reduce absorption of dietary iron...  Also a good thing!  

Virtually all breakfast cereals are HIGHLY fortified with iron, and often contain vitamin-C too, so folks with high iron should simply avoid these iron bombs.  Liver is also very high in iron and is something to avoid.  

I believe in "cycling" IP6 to be certain I'm not over-chelating important minerals like zinc.  I usually take it Monday/Wednesday/Friday for a month, and then take a week off to let trace minerals stabilize.  Chelation is not something you want to do fast, but is best done slowly.  If you take pure IP6 properly (on an empty stomach with a full glass of plain water), you WILL get results, and both serum and ferritin iron should fall.  

Happy to blab on about this if you have any other questions.  There's a great site on iron called Health-e-Iron here:
Almost too much information, but once you start reading, it quickly becomes quite fascinating.  

Get that iron lowered by hook or by crook...  No big rush, but you'll feel better and enjoy better health when you do!  


Eliminate all other factors and the one that remains must be the truth (Sherlock Holmes)
Post #12472
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 Posted 4/3/2014 1:45:23 AM


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Thank you so much for your replies fastingly and Synesthesia,

I will look into the link you've given me for more information.

However, I understood that the IP6 I'm taking is probably not able to do as good a job as an IP6 without the added minerals. Therefore, could you please tell me which IP6 you are using?

Couple you please suggest a regime to follow that includes other supplements?

Finally, do you know of any multivitamin supplements that do not have either iron or vitamin C?
Post #12485
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 Posted 6/30/2014 4:51:49 AM


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Excellent information contained in your post.  Thank You.  I joined the forum because of your post, and I plan to be an active participant.   I think the suggestion of taking supplements with a full glass of water makes a tremendous amount of sense.   Also, taking IP-6 on an empty stomach, and separate from mineral supplements is also a vital piece of information.  Thanks again.,

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