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IP-6 inositol hexaphosphate

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 Posted 6/19/2012 10:26:16 AM
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To LEF ...

IP-6, has received a great deal of attention because of its immune boosting capabilities. Phytic acid, another name for IP-6, is also known for its strong mineral binding capabilities.

Tumors often cause calcium to be release from bones causing hypercalcemia.

Would taking IP-6 be wise to take in a situation where a patient has decrease appetite, high calcium, and decreased immune function?

It appears to me IP-6 would help down-regulate blood calcium while at the same time boosting immune function. How would this effect overall bone health?

Thoughts?


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 Posted 6/19/2012 12:01:44 PM
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Although one study shows an inhibitory effect of IP6 on bone mineralization, the authors view it as part of a regulatory effect:   http://www.ncbi.nlm.nih.gov/pubmed?term=IP6%20bone Most research concludes that IP6 is associated with a reduction in osteoporosis. 

Life Extension's Cancer Adjuvant Therapy section recommends it: http://www.lef.org/protocols/prtcl-027d.shtml


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 Posted 6/20/2012 6:04:19 AM
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Sorry if I'm not addressing your question properly, but I've been taking IP6 for 6 months now to chelate excess iron and I have some input you may find interesting.  I don't have a lot of knowledge regarding your specific query.  

Aside from the anti-cancer and immune supporting action of IP6 (boosting NK cells), IP6 is also effective at binding free iron (which feeds cancer, bacteria, viruses and fungals) when it is taken properly.  Aside from these benefits, it also lowers inflammatory cytokines (TNF-a)!  

IP6 should always be taken on a very empty stomach (4 to 6 hours after meals and at least 30 minutes before eating) with a full glass of water to carry IP6 through your stomach and into your intestine swiftly for proper absorption.  Any food at all present in your stomach will largely deactivate most of the benefit you might get from IP6.  Similar problems will occur if you take it without adequate water to carry it swiftly through your stomach.  Mucus, prostaglandins, acids and gastric secretions can damage IP6 if they are not diluted with water.  

When taken properly, you really only need one or possibly two 500mg doses of IP6 per day.  I typically take it first thing in the morning or just before bed, and have noticed remarkable results at rather low doses.  Regarding the dosage, I believe some are confusing IP6 with simple inositol as I have noticed some advising dosing IP6 at several grams a day, which is the standard dosage  for simple inositol supplementation.  Many cancer forums advise taking IP6 with additional inositol, and perhaps this is where the confusion occurs.  

If I take IP6 at levels higher than 500mg, twice per day (total 1000mg/day) I get dental sensitivities, which is the only side effect I've noticed from IP6.  I have never taken more than this dosage and I believe it would be unwise to do so.  Additional simple inositol may boost the effectiveness of IP6, but I have not yet tried this regime.  

I also take low dose magnesium (citrate 200mg) with lunch (at least 6 hours away from IP6), and low dose zinc (Tri-Zinc 50), also well away from when I take IP6 to reduce the possibility of a shortage of these vital minerals.  Although studies have shown as long as IP6 is not taken with meals mineral depletion does not occur, it may be wise to "cycle off" of IP6 one week per month, or 3 days per week to allow your body to replenish trace minerals which could possibly become depleted with extended use of IP6.  After 3 months continuous use of IP6, I am now  cycling briefly off of it as I describe.  

There's a very good paper on IP6: "Effect of Inositol Hexaphosphate on Lipopolysaccharide-Stimulated Release of TNF-a from Human Mononuclear Cells" which contains a great deal of valuable information on IP6.  I highly recommend giving it a look if you are interested in this remarkable supplement.  

There's an Abstract here: http://www.pjoes.com/abstracts/2008/Vol17/No02/14.html

And the Full Study here: http://www.pjoes.com/pdf/17.2/283-290.pdf

IP6 has helped me to lower excess iron (documented by blood/ferritin testing) and the resulting inflammation it had caused due to a fatty liver, and I recommend it highly.  

Stay Healthy My Friends!  

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 Posted 6/20/2012 7:16:45 AM
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Thank you for your insight and the time posting that informative reply!

I think I found my answer.. This is a very good article for all to read (hyper-text linked headline to full article):

"Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic"

[1] "... Recent studies demonstrate that this antinutrient effect of IP6 can be manifested only when large quantities of IP6 are consumed in combination with a diet poor in oligoelements ... A long-term intake of IP6 in food or in a pure form did not cause such a deficiency in humans ... Grases et al confirmed our findings and also reported that abnormal calcification was prevented in rats given IP6 ..."
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[1] J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S.


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 Posted 6/20/2012 7:38:47 AM
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Another great read on IP6...  A remarkable supplement!  Thanks Tom. 

I would like more information on the recommendation for taking additional simple inositol with IP6 the cancer researchers are talking about.  What's the proper ratio, and what does the additional inositol provide?  Does IP6 already include the additional inositol?  

The way they speak of IP6 as the instrument of the testing/research and then in other areas speak of IP6 "plus inositol" as though it may be the same thing is confusing!  

I've read inositol is so effective at reducing cancer risk, it has even shown remarkable results in studies with current and former smokers for reducing their risk of developing lung cancer.  

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 Posted 6/21/2012 3:56:54 AM
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Tom:  I was going to recommend IP6 Inositol for your mother, but since I have not taken it myself I didn't.  One other, more traditional, treatment you might consider for her is proton therapy.
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 Posted 6/21/2012 8:52:36 AM
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Proton therapy might be an option if it weren't for the fact her non cancerous lung tissue has sustained damage from years of smoking. Any risk to surrounding tissue could seriously compromise breathing.

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 Posted 6/30/2012 8:23:29 AM
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As a side note to an interesting post (sorry I am not able to reply precisely to the questions) ...

I have been supplementing with IP6 and Inositol (in the approximate ratio 4:1 as per the CellForte formulation) for a couple of years now. Main motivation is immune system support, normal cell growth and iron chelation (*). There is some evidence also for reducing kidney stones formation (*) and cholesterol (*). Next to the good read Tom is providing, I found THIS also particularly interesting wrt slowing prostate tumor growth (*). When supplementing with IP6 I recommend also to check blood phosphorus level, I recollect evidence for higher risk of cardiovascular diseases when that is too high.

(*) conditions/concerns I have


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 Posted 9/18/2012 7:10:16 AM
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here's something interesting about using it if have cancers, but i not meaning to recommend it as solo therapy:

IP6 & Inositol  4 grams on empty stomach, such as at bedtime; twice daily could be more optimal if schedulable.  An example product is “Cell Forte IP-6 & Inositol” ultra-strength powder by Enzymatic Therapy www.enzy.com .   IP6 is inositol hexaphosphate with attached calcium and magnesium, which is a rice bran extract which was found having some effects in suppressing cancers and is a weak immune stimulant.   Part of its actions is by binding up iron which cancer usually needs more of, without affecting normal cells.   IP6 may also desirably alter the expression of ‘anti-cancer’ proteins produced by the p21 and p53 genes that help control cancer growth and apoptosis. 

 I am told that Bill Sardi (The Iron Time Bomb, author) reports several reported remissions :

 “An 80-year old man with terminal liver cancer took IP6 for a few weeks prior to a scheduled rescue procedure where an anti-tumor drug was to be injected directly into the liver. A cat scan performed just prior to the procedure revealed the liver tumor was completely necrotic — the tumor was a ball of dead cells.

A middle-aged woman whose husband worked for a prominent member of Congress, who had stage 4 breast cancer, experienced a rapid and complete remission following the consumption of IP6.

At age 70, a man was diagnosed with lung cancer. Radiologists had missed a lung tumor the size of a golf ball in an earlier x-ray. A year later it was the size of a softball. Chemotherapy reduced the tumor by 75 percent. In 1999 the man began taking IP6. By 2004 the lung tumor had completely disappeared, which was confirmed by bronchoscopy and x-ray.

A man with recurrent bladder tumors submitted to surgical removal in 1999, 2000 and 2001. He then embarked upon the use of IP6 as a dietary supplement and has not experienced a return of bladder tumors in 38 months.”

... however, what is not known is its frequency of actually causing cancers to "disappear" ... perhaps not often...

 .... and nothing said in these above briefs of cancer cases of what else the cancer patient could have took or did  (Budwig's diet, stop sugar intake, change cooking methods, took medicinal mushrooms or other beta glucans, exercise, curcumin, DIM (or more cruciferous veggies),.. or what?)

  want a non-chemo drug which may suppress cancer growth at least in a melanoma patient?   then research  drug disulfiram (Antabuse)  250mg or 500mg daily ... but this causes alcohol intake to be very nauseaous and would have to build up a tolerance to 500mg even without drinking alcohol .. zinc 150mg daily slightly improves its anti cancer results.

 (“Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease” Mol Cancer Ther 2004;3:1049-1060.) 

N-acetyl-L-cysteine supplementing would likely decrease the anti-cancer effectiveness of disulfiram by decreasing ROS ( “Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma” BW Morrison, etal, Melanoma Res., 2010 Feb;20(1):11-20.)



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 Posted 2/22/2013 7:08:33 PM
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Hi Everyone ,

Just my thoughts on this IP6 is getting more positive by theday not going into too much detail I am 50ish I have  Hemochromatosis  and been on a downward spiral for some time now Joint pain, stomach pain thirsty all the time fatigued for about 3 years till I decided to get myself to the Docs not been there for around 5 years I have hep c also due to some stupid things we do when we are young, Im now just gone 50 and paying for it, drank lots partied hard paying for it so now I have to fix it , had blood tests done not  looking good,,,

 

Ferritin- 2537 ug/l     Range   30-500

Iron- 46.9 umol/l          "      5.0-30.0

Platelets- 77                  "       150-450

GGT- 152 u/l                   "       5-50

AST- 256 u/l                    "       10-40

ALT- 327 u/l                    "       5-40

 

Now to me looking at this it is not good had to have blood lettingdone for 2 months but really didn't like it, so looking around the web found IP6 lots of research later decided to get it, found Puritins Pride IP-6 Inositol Hexaphosphate 5 x 510 mg 120 caps around $60AU with shipping well I have started a diary as well just to keep track of my progress, well and I have to say I am amazed at how I am feeling even after a few days just my inner spark of energy alertness Just an overall feeling really good above all I am even feeling horny again some may laugh but due to my symptoms I have had no libido for a long time so to me this is a miracle!,have been taking 2 caps 1.2 grams morning and night on an empty stomach and will continue to do use this I do believe in it, I will get blood tests done againin 3 months and see if there is any change, will post results  Thanks IP-6 you are a Miracle. BigGrin 



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