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Caloric Restriction

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 Posted 6/18/2012 8:26:07 AM
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Caloric restriction has been shown to work simply by restricting Methionine intake.  A new study has shown that adding 8% Glycine to the diet causes the kidneys to expel methionine and provide the 50% maximum lifespan increase that methionine restriction (caloric restriction) provides.

Glycine is inexpensive and tastes like sugar, so it is an easier regimen than dietary restriction.  Methionine sulphoxide accumulates in the body and is a marker for aging (cataracts are composed of 60% methionine sulphoxide). 

But does a glycine regime started late in life reduce the methionine sulphoxide already accumulated?

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 Posted 6/19/2012 4:47:41 AM
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From Michael A. Smith, MD:  "Methionine sulfoxide doesn’t build up. It readily converts into methionine through the activity of methionine sulfoxide reductase – one of the more stable enzymes in the human the body. It’s such a stable enzyme because methionine sulfoxide is so damaging to protein. So it needs to convert to methionine very quickly – and it does. Having a buildup of methionine sulfoxide would mean an inborn error of metabolism in the reductase enzyme and this would manifest at birth basically. I don’t think this would be compatible with life."



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 Posted 6/22/2012 5:57:20 AM
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 Posted 6/22/2012 7:45:39 AM
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TomBlalock (6/18/2012)
Caloric restriction has been shown to work simply by restricting Methionine intake.


If it were that simple wouldn't a vegetarian diet have the same CR effect?

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 Posted 6/22/2012 7:50:07 AM
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That has been hypothesized.

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 Posted 6/25/2012 8:08:31 AM
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Vegetarian diets are high in methionine, just not nearly as high as "normal" diets.
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 Posted 6/25/2012 8:40:51 AM
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 Posted 6/26/2012 6:07:17 AM
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Yes, "relatively low in methionine" for vegetarian diets.  However, not likely to produce 80% reduction in methionine:

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 Posted 2/23/2014 10:21:57 AM
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TomBlalock (6/22/2012)
Methionine sulfoxide reductase A and B are downregulated with age:





Calorie restriction restores gene expression to a more youthful state, iirc.  It also does additional beneficial changes in gene expression.   It would be interesting to see if it upregulates these enzymes back to a more youthful state.
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 Posted 3/25/2014 5:46:23 AM
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Looking around for glycine food sources, gelatin sure stands out. 
Would anyone advise against adding significant amounts of gelatine in their diet ?

Interesting, because when I was a kid, lots of people regularly took gelatin.  Popsicles I ate all summer were chock-full of gelatin, gravy, etc. Many people I knew regularly used Knox gelatine as a cooking ingredient. My grandmother often made a tea with soluble gelatine.  People took gelatin pills filled with gelatin to make their nails grow.

There is still strong interest in taking gelatin as a supplement, but now it's been re-branded and sold as expensive "collagen with hyaluronic acid" Laugh  

 



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