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Could pyrroloquinoline quinone (PQQ) be the key to immortality?

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 Posted 11/30/2010 12:06:11 PM
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In the article "Rejuvenate Your Cells by Growing New Mitochondria" - LE Magazine Super Sale 2010/2011, the concept of mitochondrial biogenesis was introduced...

"Their findings shed light on results from favorable prior studies. For example, PQQ deficiency in juvenile mice results in a 20-30% reduction in the number of mitochondria in the liver, elevated blood glucose, and impairment in oxygen metabolism. These are hallmark indicators of mitochondrial dysfunction. Yet when PQQ was put back into the diet, these pathological effects were reversed, along with an increase observed of new mitochondria.

This and additional animal model data taken together confirm PQQ’s ability to significantly boost mitochondrial number and function—a key to cellular anti-aging and longevity."

With that, I ask...

How long do you think this can extend your life by?



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 Posted 11/30/2010 12:29:31 PM
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It's impossible to provide an answer without a human clinical trial, and this type of longitudinal study has never been done, nor would it be practical.  Since some of the methods of extending maximum life span in animals affect the mitochondria positively, it could be that an agent that increases mitochondrial function might improve human LS, but that's hypothetical at this point in time.  While not ruling out a benefit on whole organism aging, it appears likely that the compound could improve health over an average or above average life span, or contribute to an increase in mean LS.   
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 Posted 1/21/2011 12:33:06 PM
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The current (February) issue of LEF magazine has a major article on PQQ.

However, all (or most) of the supplementation studies seem to be with animal models,

so the possible health benefits with humans can only be inferred.

I am interested in hearing more of the connection between PQQ and NMDA.
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 Posted 3/11/2011 3:32:14 PM
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If a person had some defective cells, cancer,  or a problem with DNA, might something like PQQ magnify the problem by creating new but defective Mitochondria ? Could PQQ cause cancer to become more aggressive or spread ?
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 Posted 3/16/2011 11:45:12 AM
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re:  If a person had some defective cells, cancer,  or a problem with DNA, might something like PQQ magnify the problem by creating new but defective Mitochondria ? Could PQQ cause cancer to become more aggressive or spread ?

From Dr Smith:

No because you are talking about specific genes producing specific proteins that are specific to the mitochondria. If someone had defects in the these specific genes, the symptoms would show up early in life, such as childhood muscular dystrophies.


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 Posted 3/21/2011 9:08:51 AM
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I really don't believe that spurring mitochondria re-growth is the answer, in itself.

Please read this article:

http://www.healthiertalk.com/telomeres-big-boss-aging-3397

Re-growth of the telomeres themselves is. Pete

* Another good read here:

http://www.healthiertalk.com/fountain-youth-or-fountain-death-my-experiences-telomerase-activation-2978


"Be polite, be professional, but always have a plan to kill everyone you meet."
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 Posted 5/11/2011 2:12:00 PM
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hey,  are we going to let someone get away calling vinegar's carboxylic acid group .. an carbonyl group ???

NO WAY !
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 Posted 2/5/2012 7:51:23 AM
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PQQ sure has some positive feedback in other places in these bogs.

I am on the side of life extension probability with PQQ, but only when with some yet not totally defined life-style, diet and supplemental regiments.

otherwise, see that PQQ causes increase in cAMP  and that forskolin does likewise and that forskolin's increase in cAMP is thought of as the mechanism for forskolin causing metastasis of cancers (nevermind that a few years back some ND pronounced forskolin as having some anticancer effects).

then there is Astragalus extracts now on sale for the life-extension effects of re-activating your telomerase enzyme activity.  And its several human studies and testimonials to show it as probably the best effective Fountain-of-Youth available. 

however, this re-activating of telomerase has the bad side of likely causing abnormal cells (and plenty exists in older people?) to progress to becoming cancerous (which even gets activation of its telomerase activity)

take those Astragalus extracts (cycloastragenol, etc) at your own risk!   If mice experiments are to humans, then for example a guy who might have been 'cured' of prostate cancer and then takes these extracts, then gets breast cancer because of this cancer progression senario.  

What lifestyle, diet, supplementals would lessen the bad side of Astragalus or other telomerase enzyme activity activators?

other worldly point:  remember excess Sugar causes glycation of proteins, etc, which would negate the life-extension benefit of calorie restrictive dieting and perhaps even negate its mimics (metformin, resveratrol, etc) ...  blood sugar below 90mg% is best,  and debatable if 75mg% is even better [though only if blood sugar does not surge high after eating?]

Resveratrol may not be the answer, ... as in melanoma injected mice ( www.pubmed.org ), resveratrol caused more metastasis and usually next to no inhibition on tumor growth.


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 Posted 2/6/2012 4:38:34 AM
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There appears to be a tricky relationship between extended life span and cancer.  Cancer cells are immortalized and many of the things that benefit healthy cells benefit cancer cells as well.  Even in animals that are calorie restricted, which lowers IGF-1 (which can promote cancer), the animals eventually die, mainly of cancer.  There's also a trade off sometimes between quality of life and disease promotion.  The ultimate hypothetical example would be someone in suspended animation for whom all disease would be halted or absent.

Regarding resveratrol, there a number of studies showing that it has an anticancer effect.  For example, http://www.lef.org/newsletter/2011/1011_How-Resveratrol-Helps-Combat-Breast-Cancer.htm

It is my belief that research will find a pathway to extend life that avoids cancer.  It may come about through manipulation of various genes


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 Posted 2/6/2012 5:36:34 AM
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Evermore, see also the answer to your question at http://ask.lef.org/540/PQQ-and-Mitochondrial-bio-genesis-questions?Update=1
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