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Vitamin E - bone mass

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 Posted 4/25/2012 9:48:24 PM
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Hello!

Can you please comment this article?

http://www.nature.com/nm/journal/v18/n4/full/nm.2659.html

Because of intake LEF's 2-per-day (containig Vit E) I need more info about it. Any recommendations?


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 Posted 4/26/2012 4:56:08 AM
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My suggestion is to make sure you are using a supplement that contains the other tocopherols, particularly gamma tocopherol.  See http://www.ncbi.nlm.nih.gov/pubmed/22308007

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 Posted 5/2/2012 1:43:51 AM
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Temperion,

forget this "study".

The dosage is equivalent 42 grams alpha-tocopherol for a 70 kg human!!!!!!
(0,6g/kg bw).

Have you ever heard from anyone taken so much alpha-tocopherol?
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 Posted 5/3/2012 5:31:13 AM
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Maybe Vitamin E out of proportion with the rest of nutrients will do that, but I have higher than average bone density for both DEXA T and Z scores and I take 800IU/day. I take plenty of everything else though as well.

Not only do studies often give huge quantities of substances, much more than any sane person would take, but they often do it in isolation which maximizes the chance of problems.

Earl, direct scaling from small animal studies is not an accurate way to estimate for human quantities. If I remember correctly there is a surface area calculation that is supposed to be a little more accurate. In any case it seems likely it would take much more than what is in the LEF vitamins to cause a problem.
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 Posted 5/5/2012 3:01:29 PM
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calc (5/3/2012)
Earl, direct scaling from small animal studies is not an accurate way to estimate for human quantities. If I remember correctly there is a surface area calculation that is supposed to be a little more accurate.



Hi calc

if you come across any comparisons between body weight calculations vs. surface area could you post them in this thread?
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 Posted 5/6/2012 12:12:00 AM
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FasterThanU (5/5/2012)
calc (5/3/2012)
Earl, direct scaling from small animal studies is not an accurate way to estimate for human quantities. If I remember correctly there is a surface area calculation that is supposed to be a little more accurate.



Hi calc

if you come across any comparisons between body weight calculations vs. surface area could you post them in this thread?


I attach herewith a paper which can be interesting on the human equivalent dosage.


 Human Equivalent Dose.pdf (8 views, 86.05 KB)
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 Posted 5/6/2012 4:00:44 AM
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Thanks for bringing that paper to my attention.  I had never previously heard of using body surface area as the conversion factor, rather than weight.
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 Posted 5/7/2012 8:21:42 PM
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Albedo, thanks for the link! :-)

If I did the math correctly it would only be 3.4g of alpha-tocopherol for a 70kg human, but thats still a massive amount. 800 IU by comparison is only 536 micrograms, or roughly 0.015% of the potential dosage for humans.
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