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Need help with lung cancer

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 Posted 4/18/2012 7:07:18 AM
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Hi everyone,
Over the years I've enjoyed interacting with all of you and helping where I can. Now I need your help, knowledge.

My mother has recently been diagnosed with stage 4, poorly differentiated, metastatic, non small cell lung cancer.  The mass is in her right lung and has metastasized into the pleural space (the space between the lung and the chest cavity). She's already had talc pleurodesis surgery and is in the hospital in recovery. She is off breathing tubes and eating semi solid food now. She has long been a supporter of life extension type practices, eating right, supplementation and exercise. Her chronological age is 72 but her biological age is more like 52.  She's said she would like to try chemotherapy.

A couple of things I read ...

First and foremost I'll get her started on Artepillin C (3,5-diprenyl-4hydroxycinamic acid), and CAPE (caffeic acid phenethyl ester) as I wrote about HERE

Other therapies I've read so far..

Curcumin has shown remarkable promise in conjunction with chemotherapy, partly because it acts as an angiogenesis inhibitor and COX-2 inhibitor. Although curcumin's bioavailability of benefits is very low.  However a synthetic analog of curcumin known as 1,5-bis(2-methoxyphenyl) penta-1,4-dien-3-one or (B63).  B63 has shown "... a higher chemical stability in cultural medium and a better intracellular profile than curcumin." Read the study abstract HERE.  How would I go about getting this compound? Does anyone know?  What would you recommend as the best form of curcumin?

LEF recommends "statin" drugs as an adjunct therapy, however, data also exist against the use of statins for the chemoprevention of cancer as written in this CHEST journal article.. READ HERE What is LEF position on this information?

If you know of any other therapies, protocols, etc... please let me know and I'll look into it.  

Thanks in advance for your support.

-Tom


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 Posted 4/18/2012 7:28:17 AM
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Hi Tom, Sorry to hear about your mother's situation.

Here's a link to get some foundation on the disease and a better feel for solutions.

http://www.lef.org/protocols/cancer/lung_cancer_01.htm

I'm sure others will have some ideas too.

I know the LEF has a curcumin supplement that's much more absorbable than regular curcumin.

If I think of anything else I'll post.


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Post #5744
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 Posted 4/19/2012 7:17:36 AM
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Hi Tom,

My aunt had the same cancer, and same operation. A non smoker to boot. After a year or so it was discovered that the origin might be from her ovaries.  

Please make sure that the doctor checks the Ovaries.

Prayers to you mom..............

After 4 and a half years my aunt passed away this past October. She was one sweet lady.......

rich
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 Posted 4/20/2012 4:30:57 AM
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Sorry to hear of this, Tom.  Arnold Smith, MD in Greenville, Mississippi, has had success with his protocol for non-small cell lung cancer.  See http://cancernet.com/

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 Posted 4/21/2012 9:20:28 AM
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Thanks George, Rich, DDye...

Yes, I've read that the innate immune system is cirtical in the prevention of cancer. Dr. Arnold Smith uses immunotherapy combined with chemo and radiation to help the patient.   My mom isn't a candidate for chemo or radiation because she is too weak.  Along the lines of Dr. Smith, I've also read that strengthening the immune system nutritionally can help. Have any of you heard of Dr. Lorraine Day? She apparently cured her breast cancer via natural remidies. check out her story and see pictures on Her website here  What do any of you think of this?

-Tom


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Seize every opportunity to put your best foot forward.

Anything worth doing is worth doing well.
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If everything seems under control you're just not going fast enough. - Mario Andretti
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 Posted 4/21/2012 11:02:08 AM
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Hi Tom. I am sorry to hear about this and remember the same case with my mother, at 82 though.

There are a number of good resources around you can consult and I am sure you already know, such as:

http://www.cancer.gov/clinicaltrials/ for ongoing clinical trials and preliminary results,
http://nccam.nih.gov/ for complementary and alternative approaches,
and of course http://www.cancer.org/

A discussion forum I often consult is also longecity (search on NSCLC)

If chemio is used, integrative approaches might improve the outcome, e.g. acupuncture might be of benefit to prevent nausea, spirituality/prayer can reduce anxiety as well as yoga, meditation and group support.

Of course you have the weaponry of nutrition you teach us. I would be careful about antioxidants which might interfere with chemio. With what you mentioned (e.g. curcumin) I would consider green tea and also grapeseed extract (proanthocyanidin) the latter has supportive studies HERE  and HERE (though only in vitro). I would also look at melatonin, e.g. see HERE.

I hope this help. if there is something effective for you mother, I trust you have all means to find it!


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 Posted 4/23/2012 4:07:01 AM
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Dr Smith may be willing to work with her.  Another option might be Cancer Treatment Centers of America.
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 Posted 4/29/2012 12:11:05 PM
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The most frightening thing about all of this is the fact that cancer is a silent killer. Anyone can have cancer lurking inside and be asymptomatic. My mom must have had it for years before it caused fluid on lungs and thus outward symptoms.

A medical program I was watching the other day talked about a man who just suddenly died during dinner. Autopsy reveled he had colon cancer which spread throughout his body for years undetected. The cancer finally caused a blood clot, possibly giving him a silent heart attack destroying a part of his heart. Eventually the area of his heart was too weak to withstand the pulsation, bursting a hole filling the sac around the heart with blood, choking his heart.  This is what they postulated from the autopsy. They assume if he had any symptoms the cancer would have been found. All of this was occurring inside his body even though he looked and felt healthy.

So my point to that last bit of information is to demonstrate how serous cancer is and how any of us could have it and not know. Pretty scary if you ask me.  It's important to take measures to prevent it.  The immune system is vital. When the immune system is strong it can whisk away damaged cells and such before they mutate and spread.

What I've found so far is suppressing TNF Alpha and NF-KappaB, is important. A few links below:

NF-kappaB in cancer: from innocent bystander to major culprit.

Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.

An Essential Role for NF-kappa B in Preventing TNF-alpha-Induced Cell Death

Another interesting link about CAPE:

Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells.


-------------------------------------------------------------------------------------
Seize every opportunity to put your best foot forward.

Anything worth doing is worth doing well.
If you don't stand for something, you will fall for anything
If everything seems under control you're just not going fast enough. - Mario Andretti
You can't expect to do business today, with yesterday's tools, and be in business tomorrow. - Author Unknown
------------------------------------------------------------------------------
The case against dietary fats >>  CLICK HERE


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 Posted 4/30/2012 10:03:14 AM
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I thought I'd post information I find so that it may help someone else dealing with this horrible disease.

Another therapy is targeting the cell proteasome via its activity inhibition. This approach prevents the cell from degrading/removing proteins/waste creating build up and eventually cell death. Unfortunately as with most cell-targeted therapies, they actually accelerate the aging process via the death of healthy cells.


The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer

Velcade (Bortexomib) the first FDA approved, proteasome inhibitor drug.


-------------------------------------------------------------------------------------
Seize every opportunity to put your best foot forward.

Anything worth doing is worth doing well.
If you don't stand for something, you will fall for anything
If everything seems under control you're just not going fast enough. - Mario Andretti
You can't expect to do business today, with yesterday's tools, and be in business tomorrow. - Author Unknown
------------------------------------------------------------------------------
The case against dietary fats >>  CLICK HERE
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 Posted 4/30/2012 11:22:33 PM
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Doesn't everyone have cancer? Our cells multiply and divide trillions of times. One would have to be pretty naive to think that each time a cell divides that it divides perfectly without any flaws. Hopefully in the near future we'll find a means to root out these rogue cells through nanotechnology, stem cell research, etc. That is if the powers at be will let us. I guess for the time being there are a few nutrients that can be taken to boost the immune system and or decrease the spread and growth of these malignancies.
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