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Why do hormones deplete with age?

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 Posted 3/8/2012 4:20:36 AM
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No.

That was in answer to your second question, concerning hGH.  Even with hGH, my reply stated that it may accelerate the aging process, because that hypothesis is based on animal and other nonhuman research.


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 Posted 3/8/2012 5:16:13 PM
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It seems to be the aspect we understand the least about ageing - hormone depletion over time. Everything else seems to have a reason; from UVA causing collagen loss, wrinkles to form, to glycation causing other problems inside, free radicals, telomeres shortening etc. But what of hormones? They just deplete....for a laugh. Generally your body does things that make sense. You cough when your lungs contain unwanted particles, your body digests food when ready, excretes waste as necessary....it all makes sense. But this doesn't.

I really think finding out at least the reason for hormones depleting is gonna be the biggest step towards anti ageing. Before you find out the real reason, you can't attempt to prevent it. Supplementing hormones that deplete is not the best method, but perhaps the only method. Its like subsidising a trader who consistently loses money instead of finding out why he loses money trading and fixing that. Easier said than done though in this case.
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 Posted 3/9/2012 5:16:03 AM
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Our bodies, like most machines, are transducers:  they change energy from one form to another, more useful form.  But the conversion is not 100% efficient, so there is entropy created in the form of oxidants.  This is why it is necessary to take anti-oxidants to counteract this effect.  If you maintain the correct chemicals in your body, you will produce the correct kind and quantity of hormones.
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 Posted 3/11/2012 6:25:45 PM
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I read Breakthrough by Suzanne Somers and she gave the following explanation (I'm not remembering the exact way it was described in the book but this is close).  I'm also drawing from information I've read on hypothyroidism/Hashimoto's disease.  I'm not a medical professional so...take this for what it is.

The thyroid gland is, literally, made from cells that hold the T3 hormone.  As the gland releases the hormone over time, it does so by releasing cells and physically decreases in size.  As we age, the gland naturally shrinks.  The problem is, our endocrine system was only designed to support us through out late 30's (this is when death naturally occurred before all of today's medical advances that have allowed us to live longer).  Think of it as a tank of fuel the body runs on - when it runs out, you die.  (I don't mean that you literally die when the thyroid runs out....I mean, you die when you run out of hormones).

I've read elsehwhere that, with Hashimoto's, the immune system will attack the thyroid, destroying tissue, which forces a release of T3 into the bloodstream (which the body needs).  Again, this implies (to me) that the tissue itself IS the hormone.  You only have so much thryoid tissue....so much adrenal tissue....etc

This is where I'll inject my own ideas (which may not be accurate).  You may have read that when you supplement, your body senses the additional hormone and slows its own production.  This wording is a little misleading.  It doesn't slow production - it slows release.  To say it slows production, implies it has the ability to generate an additional hormone supply.  I don't think this is the case.  You have the supply you were born with and that's it.  I think the cells may shrink and expand just like any other cell can - but you're not ever going to generate more thyroid tissue.  I'm guessing the same holds true for all of the other glands too.

So the only thing doctors can do is either figure out how to genetically modify us so we are born with larger endocrine glands (bigger fuel supply) or, figure out a way to make the gland regenerate.  Neither seems like an easy task.

There's a guy who owns a yahoo group dealing with anti-aging and HRT.  He actually advocates the use of insulin long before you are diabetic (the idea being you reduce the demand on your pancreas now so you have insulin later).  I found the idea interesting (maybe radical) but never thought seriously about using insulin at this point in my life.  I'm definitely one to push the boundaries but this is one I've yet to try.


41 yr old female, Maryland
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 Posted 3/12/2012 4:20:06 AM
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I don't think your hypothesis is correct, but its good to be open minded in the field of medicine and health.  That's how new discoveries are made:  by thinking outside the box.
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 Posted 3/13/2012 6:33:59 AM
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Organs and glands wear out with time, just like any machine.  You therefore have to supply energy and nutrients exogenously to repair the glands or help them to function.  This means taking certain precursor molecules like, for instance,  iodine and phenylalanine to help the thyroid operate properly.
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 Posted 8/16/2013 12:24:34 PM
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When I read these comment, I never see anybody refer to the brain/mind thought process....I can give you the reasons to your questions, however, it will take too long here.   However, I will approach another important subject, one you guys have given any thought to.   From the age of 25 years sperm is splitting, dividing, ageing, declining, deteriorating, worsening, weakening and increasingly mutating. So he is already on the decline.  By the time a man is 50, he has 850 mutations in his sperm.   Women's eggs do NOT split, divide, age, decline, deteriorate, worsen, weaken and never mutate. Her eggs remain the same from her teen years until she reaches menopause.   Everything a man takes into his body on a daily basis, food, nutrition, negative thoughts, environmental toxins, totally everything, drugs, smoking and alcohol, crosses the threshold of his sperm....causing more mutations that he passes onto his offspring.... A man should NOT have children over the age of 40 years.   Look up "paternal age effect" on the internet and see the problems sperm is causing...men's mutating sperm, (along with, genes keep switching on and off on a daily basis), cause schizophrenia, autism, every mental disease, breast cancer in women and hundreds of diseases....even still-births and pre-eclampsia in pregnancy....older men are causing a big problem, with splitting, ageing, declining, worsening, weakening mutating sperm, and older men's  produce children with less intelligence.....it is men's sperm that has brought the decline in health in the entire population. Men's own sperm has betrayed them.   Remember that everything, and I mean everything, even bad thoughts, crosses the threshold of the sperm....increasing mutations....Dr. R. De Avene. 
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 Posted 8/18/2013 12:47:45 AM
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Transpower (3/5/2012)
As we age, entropy sets in, and we must counteract this by energy.  Our bodily chemistry degrades and so we must supplement to keep our bodily chemistry functioning like it was when we were young.  The whole point of orthomolecular medicine is to determine which chemicals decline as we age and therefore what natural chemicals to take in from the outside to counteract the decline.


So very well stated Transpower. You, at times, so very well state what this life extension all about. I do believe BHT [ butylated hydroxytoluene ] is among the very best compounds available at this time for life extension. In my opinion and a very many others BHT does in fact counteract the decline as you put it by deactivating free radicals and reactive oxygen species. As people age their bodie`s cells gradually lose the ability to cope with those extremely destructive chemical entities. Myself and many others believe BHT is of great value in aiding people`s bodies in coping with said destructive chemical entities. A proven means of counteracting this entropy you discussed to some limited degree.   ...Oscar
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 Posted 9/7/2013 7:42:42 PM
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"Women's eggs do NOT split, divide, age, decline, deteriorate, worsen, weaken and never mutate. Her eggs remain the same from her teen years until she reaches menopause. "

i'm sorry but this is plain WRONG. women's eggs do deteriorate starting mid twenties and it accelerates after 35. that is why so many women are experiencing infertility now because they delayed childbearing: additionally research is showing that this also has an influence on the development of breast cancer.

everything they expose themselves to has a detrimental effect on eggs and it erodes quality over time. that is why young people who trash their bodies can still get pg but after years of it, it makes them infertile. long term smoking speeds up menopause by 2-4 years.

fertility doctors can weed out unhealthy sperm and supplementation and daily ejaculation can help with quality; there is no treatment or procedure for egg selection or rejuvenation.

try searching for terms 'getting pregnant after 40' and you will find out all about it.
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 Posted 9/12/2013 9:26:33 PM
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It is very common in men and women when it comes to depletion of hormones as the age passes. but at the same time it is not neccessary to stay with less hormone level through out. Hormone by name primarily testosterone is one of the main thing for the growth of hormone level in the body.
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