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PQQ and Mitochondrial bio-genesis questions?

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 Posted 4/5/2012 4:13:34 AM
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Perhaps your immunity is low, but my best guess this time of year is maybe allergies, outdoor or indoor.  The way I deal with supplements is that if it causes me concern, I don't take it.  I rely on the ones that work for me or have really good science behind them.  Maybe it is not the PQQ, but lack of something else that is causing your colds.  Doesn't PQQ come from KIWI?  If so, then KIWI is, also, loaded with vitamin C...must work together.
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 Posted 4/10/2012 2:29:41 PM
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Death to confusion?
A good question for me too.
--G


Plover (2/25/2011)
Are you saying that plain PQQ might not be safe unless taken with other things or that it is unsafe with vitamin C? This is very confusing.  The article in the LEF magazine did not  elude to any problems that could come from taking PQQ.
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 Posted 6/4/2012 11:10:17 AM
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phoenixironfist (4/4/2012)
DDye (12/19/2011)
These nutrients can be consumed during colds or influenza.
I was taking 10mg a day (Mitochondrial energy optimizer) and I got a cold four times.. Not sure if it was related to the PQQ somehow. I stopped the PQQ and didn't get the cold again. Could the cold be a mitochondrial side effect as in overdoing it somehow? I was exercising too when I didn't have the cold. My diet is usually a low carb one which I've just read can trigger mitochondrial biogenesis too.....


Pheonixironfist, I've actually noticed the same thing during my experiments with PQQ... CoQ10 alone doesn't cause any problems, and actually produces a noticeable increase in energy. However, once I add PQQ to the mix, I start having cold symptoms 3-5 days later (runny nose, congestion, yellow mucus, lower energy). This has happened to me twice now! Both times, the only thing I added was PQQ.

I don't know what the mechanism is (maybe PQQ suppresses immune function in some way?), but definitely something to watch out for.

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 Posted 6/4/2012 11:16:58 AM
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Have been taking PQQ for a year now and have had fewer colds than usual.  Attributing it to PQQ would be premature, as it could be due to a number of factors.

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 Posted 6/4/2012 11:24:57 AM
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DDye (6/4/2012)
Have been taking PQQ for a year now and have had fewer colds than usual.  Attributing it to PQQ would be premature, as it could be due to a number of factors.


All I'm stating is my experience, take it for what it's worth, but I've started taking PQQ daily two times now and both times I've come down with a cold 3-5 days after starting PQQ (no other factors changed)...

Other than those two instances (which admittedly were pretty mild and abated once I discontinued PQQ), I haven't really been sick in over 2 years. It just seems like there might be something else here we're missing, and I think it's definitely worth investigating. Is there any research on PQQ's effect on immune function?
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 Posted 6/4/2012 11:30:30 AM
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These were the only two relevant abstracts retrieved in a medline search for PQQ, pyrrolequinoline quinone, immune and/or immunity:

http://www.ncbi.nlm.nih.gov/pubmed/19803551

http://www.ncbi.nlm.nih.gov/pubmed/8169668


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 Posted 6/19/2012 6:33:47 AM
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I didn't have another cold - thanks to taking some ginger tea/water too -  and I've recently resumed taking the supplement, but not daily (I take it for 4 days and then 3 days I don't. On 2 of those I take a maca supplement instead.) I didn't get another cold by the way. 
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 Posted 4/6/2014 8:36:28 AM
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Looking around, trying to discover the typical amount of pyrroloquinoline quinone found in the diet, I'm finding evidence to point to the idea that most people are consuming this essential nutrient at the rate of less than 600 mcg. per day, and someone who eats from an extremely healthy diet that includes fermented foods is going to get maybe more in the range of about 1 mg. per day, possibly even 2 mg. per day. Given this, it seems that even a supplementation of 1 mg. of day to insure intake could provide benefit.
I'm interested in pqq because it appears to be an essential nutrient. Theoretically, CoQ10 is made by your body and not an essential nutrient while pqq is (though supplementing with CoQ10 is definitely helpful).

I've decided to both save money and go about experimenting with pqq slowly by measuring a tiny daily dose of powder that I eyeball-measure to be somewhere between 1 and 3 mg. per day.  Even just this tiny dose, over the past month I've felt like I'm noticing a difference in recovery times between sets of sprinting exercise, I may start upping my dose here soon.



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