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PQQ and Mitochondrial bio-genesis questions?

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 Posted 5/25/2011 11:29:06 AM
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Have you considered that your symptoms could be from something else other than PQQ withdrawal? Someone mentioned statin drugs.  Are you on a statin, especially one like Lipitor?  If I was taking a statin drug and got the symptoms you have, that would be the end of statins for me.  I have a friend whose doctor assumed it was depression.  Her problems started after the statin was started.  She went downhill quickly.  Her husband said to me that her final diagnosis was ALS and she was evaluated at a big respected medical center and they linked the ALS with the statin that she was on. I concentrate on healthy fats and have an HDL of 87 every time it is checked.

Could you possibly be depressed?  Involutional Melancholia can set in about 40-55 years.  Is your blood sugar too high? Is it possible that the PQQ is lowering your blood sugar and that it goes back up when you stop taking it?  Are you getting enough quality sleep?  Are you taking allergy medicines?  Evaluate what drove you to start supplementing with PQQ.  Was there a particular need or feeling of something wrong before taking PQQ.   Are you taking prescription drugs?  Have you had your thyroid checked?  Maybe you should get a medical work up.

I take PQQ basic in the AM and plain in the PM. I, also, take a lot of other supplements, many from LEF. I am 71 and take no prescription drugs.  Some days, but not too many,  I have a total pill fast and take nothing and eat little.  I ran out of the PQQ and was out over a month and noticed no change.  It is normal for me to have some days that are not so active and feel a little down.  If I have more than two of those days, I take one per day of  my Sam-E 200 mgm pills for about two to three days.  That gets me up and hopping again. I used to take it more often for osteoarthritis of the hip.  That went away in about six months on Sam-E after having had it for years. 

For some reason I've had a lot more energy lately and I think it is related to sleeping much better most of the time,  healthy food, lots of pure water,  more activity (exercise), losing 12 pounds (not easy) over the last year and supplements.  I started taking supplements in my 20's because I had an unhealthy habit, smoking.  I kicked that almost 8 years ago.  I, also, avoid doctors since they make me nervous. They order way too many tests and x-rays that I kindly have refused.  Sometimes things just go away on their own. About every two-three years, I will take blood tests, EKG's etc that they order.

Probably if I were as young as you are, I would be going to the doctor if something was making me weak and driving me to bed in the daytime.

I would, also, be interested in hearing if anyone else is having withdrawal from PQQ.
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 Posted 11/14/2011 2:17:32 PM
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Hi 

There was a discussion about the right time to take PQQ in regard to taking Anti Oxis. 

Was there a solution?

I have the Two per Day, Resveratol with grape, PQQ, Dig. Enzymes, Green Tea Extract, ALA, Black Tea Extract, Q10, Carnitine, Quercetin, Carnitine, Chlorella, Spiruella.

I take most of it after waking up with a protein shake on a non regular basis except for the two per day which I talk in the morning and the evening. 

Should I not take the PQQ with the other sups? What about training days? 

And maybe its a bit OT but it was also a discussion about Anit Oxi and intense training. Should I avoid any Anti-Oxidants after work-out?

Best regards

Raphael
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 Posted 11/15/2011 4:37:43 AM
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We stopped taking PQQ. It did not seem to do anything.  We took both varieties for quite a while. I have heard that PQQ comes from Kiwi fruit and we always eat a lot of that.
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 Posted 12/18/2011 2:40:15 AM
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Just wondering, what is the recommended thing to do if you are taking PQQ and CoQ10 and get a cold or flu?

Should one stop the PQQ for the time being as it could interfere in the body's recovery process, or should one keep taking it? 

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 Posted 12/19/2011 4:27:39 AM
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These nutrients can be consumed during colds or influenza.
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 Posted 12/19/2011 4:30:24 AM
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thanks Smile
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 Posted 12/19/2011 1:46:54 PM
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I was interested in the comment that kiwi contains pqq, so looked up this table of foods containing it.  Coke contains a significant amount of pqq...I wonder why?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136652/pdf/biochemj00065-0028.pdf
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 Posted 12/19/2011 3:00:02 PM
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No wonder I didn't see any results from PQQ.  That list looks like my kind of food, not to mention that I take Quercetin, citrus biofavinoids, Reserveratrol and more!  I am already healthy.
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 Posted 1/16/2012 7:45:30 PM
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@Plover
"No wonder I didn't see any results from PQQ.  That list looks like my kind of food, not to mention that I take Quercetin, citrus biofavinoids, Reserveratrol and more!  I am already healthy."

The amounts listed in the ref. that charmed linked to are ng/g (= ng/ml). A nano gram is 1/1000 of a micro gram which is 1/1000 of a mili gram (mg). So it's one millionth of a mg. The values shown in the foods are in tens of ng/g. Natto is has the highest level at 61 ng/g. So if you ate a kg (2.2 lbs) of natto you would get 1000 x 61 ng = 61 micro grams = 0.061 mg. So you would have to eat 170 kg (360 lbs!) of natto to get the same amount as there is in a 10 mg supplement.

I don't claim to know what's going on here (that the supplement is providing way more than one could get from food). Possibly the supplement is not very well absorbed. Or perhaps it's like B-12 where therapeutic doses can be 1000x higher than the RDA.

I do agree that if you are already quite healthy you are less likely to notice an improvement. Not just with PQQ, but with most supplements. The trick is to figure out which ones are most likely to help you stay that way in spite of the fact that they don't make you "feel better" in the short run.
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 Posted 1/17/2012 4:33:49 AM
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Welcome, R Barkley.  Am in agreement with your statement concerning most supplements, that one doesn't feel unless grossly deficient.

D Dye
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