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Homocysteine Resist - lower dose of B6

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 Posted 4/1/2013 10:22:51 PM
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Re: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001177,
There is no definition in the study of what is considered a moderate elevation.  The assumption is a difference of 20%.  Actual levels were never measured 
Quote : " These datasets did not include measurements of blood homocysteine, but homocysteine levels would be expected to be about 20% higher with TT than with CC genotype in the populations studied." 
So is a difference between 7 and 8.4, or between 10 and 12?   How accurate are these expectations?  
I agree that one doesn't need to be fanatical about homocysteine suppression if the level is below 10 after taking a relatively safe moderate dose of 5 methyl folate, 1000 mcg.  The risks of a higher dose, may outweigh the reward.  
Perhaps one could then take TMG.
Post #8581
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 Posted 4/1/2013 10:59:45 PM
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Strange, I cannot open the link, will check later during the week.
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 Posted 4/19/2013 5:45:27 AM
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One of my favourite health books: The H Factor Solution: Homocysteine, the Best Single Indicator of Whether You Are Likely to Live Long or Die Young 

I'm not lazy...i just don't finish anythi
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 Posted 4/20/2013 1:39:09 AM
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Thank you. Also read it and actually let me pay attention to my homocysteine. However Holford is quite controversial and in my case the protocol pretty failed as probably too oversimplified. I still think however there is a value for the general population.
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 Posted 4/20/2013 2:42:28 AM
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@Kenzworld (sorry, for some reason, I cannot quote your last post)

AFAIK there is no consensus on the optimal value of homocysteine even if LEF targets 7. I agree with you. My concern is maybe not really in the value itself but rather that it (was 14 one year ago and pretty sure it is rising) possibly hints to some kind of disfunctioning I should try to correct.

Also agree with you with the moderate intake of L-Methylfolate (interestingly LEF has (lowered?) the dose at 500 mcg in their "resist" formula). If I make a new try I would probably use 1000mcg L-Methylfolate, 1000mcg B12 as methylcobalamine sublingual and lower the dose of B6 they have in the formula.

We have on one side the low (if any) impact of high homocysteine on CVD which the study seems to show (hence not being obsessed!) and on the other side the higher prostate cancer risk (if any) which seems correlates with folate supplementation you might use to lower homocysteine.

For me this remains a dilemma !!

On rs1801131 (same as MTHFR A1298C) I am heterozygous GT (or AC, following different coding convention tha 23andme) and on rs1801133 (same as MTHFR C677T) I am homozygous GG (or CC). So I am set not that bad on the methylation path.

Also, when looking at the transulfuration path, converting homocysteine to cysteine:

On rs234706 (same as CBS C699T) I am heterozygous AG (or CT) and on rs1801181 (same as CBS A360A) I am heterozygous AG (or CT). As CBS looks to be up-regulating it means that even with a mutation the gene maybe works efficiently to lower homocysteine.

However, not only I have high level of homocysteine (14) but also high level of folates in blood tests (>33 nmol/l which is the high end of ref range) likely due to supplementation (very low dose of LEF multivit)

Confusing right? :-)

And of course, when trying talking to doctors, they have no clue of what I am trying to say!

Hey, one idea: why LEF does not take up this point and really makes a serious study linking genetics infos which many Members here must have in hands to the homocysteine status to the supplementation (or non-supplementation!)? So far, what I have seen, it is suggesting supplementation when high homocysteine based also on the quite frequent MTHFR gene mutation in the population. However, what about "personal supplementation" in function of our own genetic results? You can find this elsewhere (e.g. look for Dr Amy Yasko, e.g. HERE) but would like LEF looking into it? Could be a very interesting article in the magazine or a section in the book !
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 Posted 4/21/2013 2:44:09 PM
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Albedo,

Your suggestion has been forwarded to Life Extension magazine's editorial department.

D Dye
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 Posted 4/22/2013 11:10:14 AM
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Thank you DDye! Personalized nutrition similarly to personalized medicine is probably the nutritional approach of tomorrow. As big pharma is investing in the latter also big multinationals in nutrition are starting investing massively in the former. Incidentally, we might think of the folate cycle and MTHFR SNPs as an example of the approach.
Post #8748
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