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Anything to expect when taking L-Carnosine?

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 Posted 2/9/2012 3:44:03 PM
Spectator

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I've been using 500mg daily for about a month.

Has anyone felt or seen any benefits from L-Carnosine?

Thanks.
Post #5151
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 Posted 3/1/2012 9:04:09 AM
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I was about to begin supplementation with 500 mg carnosine twice a day; however, I have changed my mind.  The reasoning for this high dosage, which has been supported by LEF, is to flood the carnosinase enzymes which break down carnosine into component amino acids alanine & histidine.  However, I use a much lower dosage - perhaps only 50 mg - maybe 100 to 200 mg. for several reasons:

The first is carnosinemia, a genetic defect in carnosinase resulting in high blood levels of carnosine.  I don't know if these people live longer, but they do have the following symptoms: seizures, demylination, axonal degeneration, temors  and mental retardation. 

Marios Kyriazis an anti-aging reseracher, reports that in a study using 50 mg. carnosine for 1 to 4 months, the following positive effects were reported:  "Five users noticed significant improvements in their facial appearance (firmer facial muscles), muscular stamina and general well-being. Five others reported possible benefits, for example better sleep patterns, improved clarity of thought and increased libido. The rest did not report any noticeable effects. This is not surprising because supplementation with carnosine is not expected to show any significant noticeable benefits in a short time, but it should be used as an insurance against deleterious effects of the aging process. If any benefits are noted, these should be considered as an added extra bonus. It is worthwhile persevering with the supplementation long term, even if you do not experience any obvious benefits, as you will still be well protected against aging."  He questions the need to flood the carnosinase enzymes.  He also reports 'I have not noticed any side effects in those using up to 200mg a day, even after 2 years of continuous use. I have only noticed one case of disturbing muscle twitching in a patient using 1000mg of carnosine a day for a few days. This improved after stopping the carnosine.' 

Although he saw no side effects at 200 mg., If it were causing mild neuronal side effects, they might not be noticed as witnessed by an 80% loss of DA neurons before signs of parkinson's disease are apparent. 

Reading articles on carnosine without any mention of carnosinemia shows the pathetic knowledge level of the writers.  This is as bad as those with no awarness of the nutrition literature.

Wayne


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Post #5385
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 Posted 3/6/2012 5:05:43 AM
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Life Extension has received no reports from members who have purchased carnosine in regard to adverse effects related to carnosinemia. 

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 Posted 8/4/2012 7:29:07 AM
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Has anyone experienced a lot of changes after adding carnosine? Some supplements seem to help you a little each day, but others seem to start a change process that takes weeks or months to stabilize.

I've been taking 500 mg carnosine 2x for about six weeks. At first I didn't notice anything, but the past few weeks I feel like everything is changing rapidly. I'm tired for a few days, then have plenty of energy. Yesterday I was irritable at lunchtime, then almost manic in the afternoon, then irritable again at bedtime. Increased libido today, after almost none for a month. Decreasing muscle pain (fibromyalgia) over the past month. The only other thing I changed recently was to increase inositol (from 2600 mg to 5200 mg).

What are others experiencing with carnosine?

Thanks,
Elaine
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 Posted 8/4/2012 7:39:20 AM
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I have been taking 1000 mg of carnosine daily for several years and have not had any adverse side effects.
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 Posted 8/9/2012 7:08:13 AM
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Has anyone here looked into Beta-Alanine? There is a lot of research showing that it does a better job of raising intra cellular carnosine levels than carnosine itself, somewhat in the same fashion as L-Citrulline vs L-Arginine.

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