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 Posted 1/25/2012 10:43:16 PM
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Has anybody tried the coffeegenic (chlorogenic acid) supplements? I'm interested in taking it for its reported glucose control capabilities. Just wanted to get others experiences if they have taken it. What are the positives/negatives? I run 3-4 times a week for 2-3 miles. Would taking this on days I run benefit the runs or adversely effect them?

Thanks
Post #4972
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 Posted 1/26/2012 1:34:15 AM
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Good question, me to.

The CoffeeGenic Green Coffee Extract 200ml has 6 mg of caffeine
versus the CoffeeGenic Green Coffee Extract 400ml has 12 mg of caffeine.
Which if can I take if I do not sleep well becaucse of coffee consumtion.



triplecrown (1/26/2012)
Has anybody tried the coffeegenic (chlorogenic acid) supplements? I'm interested in taking it for its reported glucose control capabilities. Just wanted to get others experiences if they have taken it. What are the positives/negatives? I run 3-4 times a week for 2-3 miles. Would taking this on days I run benefit the runs or adversely effect them?

Thanks
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 Posted 1/26/2012 9:29:52 PM
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Post #4988
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 Posted 2/8/2012 9:41:38 PM
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Anybody?
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 Posted 2/9/2012 4:57:36 AM
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From the report http://carcin.oxfordjournals.org/content/27/2/269.full.pdf+html

"Global hypomethylation, accompanied by region-specific hypermethylation, is a common characteristic in tumor cells."

"In summary, while no significant change in the global DNA methylation status was detected, treatment of cultured human breast cancer cells with caffeic acid or chlorogenic acid caused a concentration-dependent inhibition of DNA methylation in the promoter region of the RARb gene in cultured human breast cancer cells."

 



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 Posted 2/9/2012 10:10:09 AM
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Thanks for the reply DDye.

I remember reading in past studies that coffee intake increases homocysteine levels to a degree. I was just curious if the chlorogenic acid an cafeic acid in coffee is what produces this rise in homocysteine. Coffee in itself I think has at the most 150mg of chlorogenic acid. So if it is the culprit would taking 400mg  in supplement form be safe?

Other things also raise homocysteine levels, such as the drug metformin. They say to take additional b12 if on metformin.

Do you think taking in more vitamin b12 will offset the rise in homocysteine? (I already take 1mg of b12 a few times a week) or would b12 even  matter since chlorogenic acid possibly inhibits methylation altogether?

Sorry if I seem a little confused on the topic. I am. Ermm
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 Posted 2/9/2012 10:19:44 AM
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From the abstract: 

The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols.



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 Posted 2/19/2012 4:30:33 PM
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Reading abstracts aren't my specialty. I basically gather from this that chlorogenic acid inhibit methlyation and therefore would increase homocysteine. So in other words this = bad.

Coffeegenic is in a lot of LEF products(Glucose control, calorie control formula, mega green tea extract etc.) Will taking all these provide to much chlorgenic acid? Is there a upper limit in regards to dosage?
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 Posted 2/20/2012 4:32:08 AM
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When looking at nutrients, good/bad is not an accurate way to look at it.  Methylation for the most part is favorable to the body, but the methylation of specific genes is not. 

Yes, there is an upper limit to chlorogenic acid dosage.  According to a report prepared by the National Institute of Environmental Services:

"For both chlorogenic and caffeic acids, the oral LD50

for redwing blackbirds was greater than 100 mg/kg (0.282 and 0.555 mmol/kg, respectively).

Few toxic effects resulting from acute exposure to chlorogenic or caffeic acid were noted in the reviewed studies. In rats dosed intraperitoneally (i.p.), chlorogenic acid at 4000 mg/kg (11.29 mmol/kg) induced death in 4 of 6 animals, and caffeic acid at 1500 mg/kg (8.326 mmol/kg) induced death in 5 of 8 animals, but doses of chlorogenic acid and caffeic acid lower than 2437 mg/kg (6.878 mmol/kg) and 1250 mg/kg (6.938 mmol/kg), respectively, were non-lethal.

Subchronic exposure of mice to chlorogenic or caffeic acid in the diet reduced aryl hydrocarbon hydroxylase (AHH) and glutathione-

S-transferase (GST) levels in the intestine, but did not induce clinical symptoms of toxicity. In rats, the effects of feeding chlorogenic or caffeic acid in the diet include reduced kidney and adrenal weights (chlorogenic acid), hyperplasia of the forestomach (chlorogenic and caffeic acids), and increased antioxidant capacity (caffeic acid)."

(The LD50 is the amount of a substance it takes to kill half of the animals tested.)



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 Posted 2/20/2012 1:02:38 PM
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triplecrown (1/26/2012)
Has anybody tried the coffeegenic (chlorogenic acid) supplements? I'm interested in taking it for its reported glucose control capabilities. Just wanted to get others experiences if they have taken it. What are the positives/negatives? I run 3-4 times a week for 2-3 miles. Would taking this on days I run benefit the runs or adversely effect them?

Thanks

Hi Triplecrown. It looks an interesting product but I did not try it. I would (if I was not trying to put order on many other things!) and test my HgA1c at baseline and following 3 months supplementation. Does it make sense?


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