LifeExtension Metabolic Pathway Map Reveals New Phytonutrient Candidates
The health food stores and giant pharmacy chains are awash with a bewildering array of hundreds, if not thousands of natural (and otherwise) dietary food supplements and herbal extracts from the four corners of the world. Just walking down the aisles should institute some form of clinical depression.Where to begin? How does one separate the questionable legitimacies of folk remedies, old wives’ tales, heap big mojo shamanism, venerable ancient medical wisdom, mythology, cultural favorites, modern marketing snake oil hucksterism, etc. from actual fact and good medicine? As an alternative to taxing our already enfeebled brains, we hit on the best idea we’ve had in years. Instead of embarking on an interminable grand search, we let the world’s best and brightest topic specific professional brains do our thinking for us, and we went in with a strategic plan.
We embraced a copy of Disease Prevention and Treatment, published by The LifeExtension Foundation (LEF). Therein lies the combined efforts of ‘thousands of research studies and the clinical experience of physicians around the world' (to put it in LEF’s own words) devoted to the overriding purpose of life extension. After reviewing what LEF had to say, we used scientific publications and the internet to update and modernize our understanding. Having our CG/CM and CR/LE map in hand, and our three principal diseases to both direct our search and institute the strategic plan, we plunged in…
...The health food supplement world is awash in phytonutrient antioxidants, and our metabolic map has helped us to loosely classify them into three broad categories with considerable overlap. Simple antioxidants are, to put it simply, basically just antioxidants. Vitamin C is a simple antioxidant. In fact, if it doesn’t have a partner to defuse it, it becomes a pro-oxidant in its ROS activated state. Funnel antioxidants are antioxidants that both accept ROS from other antioxidants and pass their ROS activated electron(s) to a metabolic system to defuse them and to extract useful energy. For instance, the vitamin C, vitamin E, NAD sequence, sets vitamin E as a funnel antioxidant. Better yet, a little system like coenzyme Q (CoQ) and alpha lipoic acid funnel ROS energy from ROS and many other antioxidants, with CoQ being a requisite functional element in the metabolic pathway itself, for passing ROS electrons to the OX/PHOS system of mitochondria for energy capture as ATP production. In addition, alpha lipoic acid restores vitamin E and vitamin C to full antioxidant status by reducing their oxidized state; a possible recycling alternative to massive simple antioxidant dosing. Best of all, are giant macromolecular machine system antioxidants such as the mitochondrial OX/PHOS efficiency system of mitochondrial regenesis, as turned on by activated CR/LE. This third category is the big antioxidant player in our new understanding of the CR/LE phenomenon. Now, we are in a position to consider the functions of our winning candidates. Lastly, we are not going to list all of the impacts of our gold and silver medal winners, or this narrative would read like a phone book. We will bundle wherever possible and stick to main effects, hopefully, without short changing the reader.
The three big gold medal winners are … discussed here
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