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New Phytonutrient Candidates

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 Posted 1/11/2012 12:37:28 PM
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LifeExtension Metabolic Pathway Map Reveals New Phytonutrient Candidates

The health food stores and giant pharmacy chains are awash with a bewildering array of hundreds, if not thousands of natural (and otherwise) dietary food supplements and herbal extracts from the four corners of the world. Just walking down the aisles should institute some form of clinical depression.Where to begin? How does one separate the questionable legitimacies of folk remedies, old wives’ tales, heap big mojo shamanism, venerable ancient medical wisdom, mythology, cultural favorites, modern marketing snake oil hucksterism, etc. from actual fact and good medicine? As an alternative to taxing our already enfeebled brains, we hit on the best idea we’ve had in years. Instead of embarking on an interminable grand search, we let the world’s best and brightest topic specific professional brains do our thinking for us, and we went in with a strategic plan.

 We embraced a copy of Disease Prevention and Treatment, published by The LifeExtension Foundation (LEF). Therein lies the combined efforts of ‘thousands of research studies and the clinical experience of physicians around the world' (to put it in LEF’s own words) devoted to the overriding purpose of life extension. After reviewing what LEF had to say, we used scientific publications and the internet to update and modernize our understanding. Having our CG/CM and CR/LE map in hand, and our three principal diseases to both direct our search and institute the strategic plan, we plunged in…

...The health food supplement world is awash in phytonutrient antioxidants, and our metabolic map has helped us to loosely classify them into three broad categories with considerable overlap. Simple antioxidants are, to put it simply, basically just antioxidants. Vitamin C is a simple antioxidant. In fact, if it doesn’t have a partner to defuse it, it becomes a pro-oxidant in its ROS activated state. Funnel antioxidants are antioxidants that both accept ROS from other antioxidants and pass their ROS activated electron(s) to a metabolic system to defuse them and to extract useful energy. For instance, the vitamin C, vitamin E, NAD sequence, sets vitamin E as a funnel antioxidant. Better yet, a little system like coenzyme Q (CoQ) and alpha lipoic acid funnel ROS energy from ROS and many other antioxidants, with CoQ being a requisite functional element in the metabolic pathway itself, for passing ROS electrons to the OX/PHOS system of mitochondria for energy capture as ATP production. In addition, alpha lipoic acid restores vitamin E and vitamin C to full antioxidant status by reducing their oxidized state; a possible recycling alternative to massive simple antioxidant dosing. Best of all, are giant macromolecular machine system antioxidants such as the mitochondrial OX/PHOS efficiency system of mitochondrial regenesis, as turned on by activated CR/LE. This third category is the big antioxidant player in our new understanding of the CR/LE phenomenon. Now, we are in a position to consider the functions of our winning candidates. Lastly, we are not going to list all of the impacts of our gold and silver medal winners, or this narrative would read like a phone book. We will bundle wherever possible and stick to main effects, hopefully, without short changing the reader.

 

The three big gold medal winners are … discussed here

All our articles may be accessed via facebook.com/lepath

Contact us at:  lepath@yahoo.com


 



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Post #4789
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 Posted 1/27/2012 3:08:13 PM
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It would be nice to discuss this on the LEF forum, especially if we could see the graphics on the forum.
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 Posted 1/28/2012 2:38:38 AM
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I read quickly and have no pretension to understand it all but will get back to it. Interesting approach and another much needed tentative to put some order (see also the second link below) in an exploding domain of information (and misinformation) and much too often supplement marketing hype.

So can we say curcumin, silibinin and resveratrol should make definitively to our top ten (a message also for LEF?) with synergistic omega3/omega6 balanced and ALA? We can then potentially add CoQ10, EGCG, genistein and Vitamin K? I might have overlooked but could not find much on Vitamin D where your RDI is hard to get only from food and supplementation (moderate, 1000IU?) might also be recommend to stay in your 30-40 ng/mL (25OH) range.

Maybe two suggestions: one is to engage also discussion in another Forum (http://www.longecity.org/forum/) where there are quite a number of experts in LE/CR. I think your post will find interesting critics and support there. The other is also having a look to the references included in this lecture (by Michael Rae)

Thank you for sharing (liked also the cholesterol discussion).


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 Posted 1/30/2012 10:25:51 AM
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We are attempting to do that right now, but the file is rather extensive and the explanation is even moreso. We are going to need a few more days to think this through. However both the map and its description are a mere click away at www.facebook.com/lepath anytime you want them.
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 Posted 1/30/2012 10:41:01 AM
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We did not include any formal daily regimen because the Life Extension Foundation (LEF) already does so in its product recommendations and its disease prevention compendium. What we bring to the party is a life extension metabolic pathway description as a dynamic singularity. Such a description takes the loose parts of our previous disparate logics and ties them together into an integrated mechanism. We have been seeking such a hypothetical framework for decades, but it has only been during the last year or two that it has become possible. Our hypothesis is entirely consistent with the LEF philosophy presented ever since the compendiums publication in 2003. All we did was integrate it into a holism. Oh! Thanks for the link. We will take advantage of it.     
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 Posted 1/31/2012 1:34:06 AM
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Just a thought ....

I expect nutritional (incl. supplementation) regimes are quite general in term of individual response, i.e. something might or might not work for you vs another individual. Pharmacological interventions have the same problem but the level of investment and resources put in research and clinical trials by the pharma industry is probably such that the problem is mitigated. Would it make any sense to include in your framework personal genotype and genomic information as a kind on "input". Maybe complex interactions and paths can be modeled and computerized giving another potential approach to personalized nutrition (a bit like personalized medicine)?

Does it make any sense ?
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 Posted 2/3/2012 11:46:56 AM
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You bet. It makes bucketloads of sense, but at this time, more so from a scientific than practical sense because of the immense expense of individual genotyping followed by the meta analysis of matching genotypic expression to metabolomic function. Once we budget research to such a mammothly dollar intensive small scale effort (say, a few thousand people, with a couple hundred from each of, all major ethnicities) we just might be able to classify humanity into a manageably sized set of metabotypical pattern groups to allow a single individual's test matching to one of the groups in terms of a particular food supplement regimen. Even after (or if) we can create relevant categorization, a shotgun metabolomic analysis would still be necessary for each person because genotypic analysis does not include the post tranlational enzymatic and regulatory protein modifications that have an immense impact upon integrated metabolic flux: and we would need a detailed flux analysis under CG and CR conditions to identify unusual pathway segment enhancements and blockages. It is important to note that the life extension metabolic pathway is so ancient and conserved that major disruptions fail quality control during embryogenesis, resulting in spontaneous termination. It is the fairly rare and minor disruptions that survive and suffer the metabolic consequences that the vast majority of us do not share. The supplements we discuss, lightly modify core systems that must be highly functional if we are to exist at all.   . . . . . . lepathway  
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