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D3 "half-life", absorption and toxicity

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 Posted 1/7/2012 1:37:05 PM
Spectator

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Here, Jared M. Skowron says that "toxicity normally occurs at 40,000 IU per day"

My question is 7 fold:

  1. What is the toxic form 1,25(OH)D3  or  25(OH)D3?
  1. With regard to toxicity, how long does the "toxic" form stay in your system?
  1. What causes D3 to be depleted or flushed from the system?  I assume exercise, anything else?
  2. What blocks D3? (both in the gut and in the system)
  1. In terms of usage and absorption how quickly does D3 build up in the system?
  1. Should D3 be cycled? (eg take it for 2 weeks then stop for 2 weeks).
  1. What impact does 5000 IU D3 have on the liver?
For example, if I take 2000 IU per day but I (could) use 5000 IU per day I could never develop a toxic level.  I understand that all people are different, and I'm not trying to find a safe dosage; I understand that I need to have blood tests.  What I'm trying to find out is, what is the typical effective level of absorption versus the body's ability to use/store D3. 

I ask because the LEF 2 Per Day vitamins have 2000 IU of D2 and the D3 supplements have 5000 IU.

The 2 Per Day (with the inferior D2) have the same warning as the 5000 IU.   Given the inefficiencies of absorption,  it seems odd that 2 doses of 2000IU D2 can be as risky (for lack of a better term) as one large dose of D3.

If Mr. Skowron is correct, wouldn't it be highly unlikely for one to reach 40,000IU by taking 2000 IU of D2 2x per day?  Unless of course vitamin D stays, unused, in the system for a long time. 


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 Posted 1/9/2012 2:34:02 PM
Spectator

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Please don't reply with instructions/info that I've already referenced in the questions. There is no benefit, to anyone, whatsoever, in doing that.

Please don't ask me about what I do, or who I am, it is considered advertising not social interaction.
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