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Mitochondrial energy optimizer

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 Posted 12/21/2011 10:07:02 PM
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Can anybody offer feedback from their experience with this supplement?
Post #4574
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 Posted 12/26/2011 3:17:44 PM
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Dear Triplecrown,

I can offer you a litle anecdotal experience on it:

When taking anything containing lipoic acid and ALC (even back when it was called by the far less jarring name of chronoforte - product namers please note!) it does give me a little extra physical + mental energy and cognitive boost.

As regards it's anti-glycation and TNF Alpha surpressing functions I can but assume that they work as advertised as I have not undertaken blood testing while only taking this supplimen in isolation.

Hope this helps?

Sincerely, Robert.
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 Posted 12/27/2011 6:32:00 AM
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Beside a very subjective increase in physical energy/endurance and mental energy (e.g. I feel I can stay up working lale at night if necessary without much efforts) I was looking at a more objective result in my blood works, e.g. on HbA1c as glycation indicator but found nothing impressive. However, I am not sure whether HbA1c is a good indicator or MEO not effective to that scope. I am waiting for new results and if I find something interesting I will report. Btw, I am supplementing separately the ingredients of the MEO and like R-ALA, ALC and carnosine mostly. What I found a bit discouraging is the apparent lack, AFAIK, of human studies on R-ALA but i keep using it with ALC mostly based on LEF recommendation and works by B Ames (see also Juvenon)
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 Posted 1/26/2012 10:30:42 AM
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Do most people take this twice a day on an empty stomach.  I'd prefer to take it all at once in the morning. also, is there a water soluble coq10 to take with it?
Post #4982
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 Posted 1/26/2012 10:40:07 AM
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The recommendation is:

"Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.

This product can be taken with or without food."


Coenzyme Q10, by its nature, is fat soluble.  It is therefore best absorbed with some kind of fat.

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 Posted 5/17/2012 10:59:23 AM
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... What I found a bit discouraging is the apparent lack, AFAIK, of human studies on R-ALA but i keep using it with ALC mostly based on LEF recommendation and works by B Ames (see also Juvenon)

Sorry to quote myself but I need to probably correct this. At least the following study, despite a bit old and done over a short period of time, shows a very positive result of lipoic acid supplementation against oxidative stress for healthy humans.

"In vitro studies have shown that alpha-lipoic acid (LA) is an antioxidant. There is a paucity of studies on LA supplementation in humans. Therefore, the aim of this study was to assess the effect of oral supplementation with LA alone and in combination with alpha-tocopherol (AT) on measures of oxidative stress. A total of 31 healthy adults were supplemented for 2 months either with LA (600 mg/d, n = 16), or with AT (400 IU/d, n = 15) alone, and then with the combination of both for 2 additional months. At baseline, after 2 and 4 months of supplementation, urine for F2-isoprostanes, plasma for protein carbonyl measurement and low-density lipoprotein (LDL) oxidative susceptibility was collected. Plasma oxidizability was assessed after incubation with 100 mM 2,2'-azobis (2-amidinopropane) hydrochloride (AAPH) for 4 h at 37 degrees C. LDL was subjected to copper- and AAPH-catalyzed oxidation at 37 degrees C over 5 h and the lag time was computed. LA significantly increased the lag time of LDL lipid peroxide formation for both copper-catalyzed and AAPH-induced LDL oxidalion (p < .05), decreased urinary F2-isoprostanes levels (p < .05), and plasma carbonyl levels after AAPH oxidation (p < .001). AT prolonged LDL lag time of lipid peroxide formation (p < .01 ) and conjugated dienes (p < .01) after copper-catalyzed LDL oxidation, decreased urinary F2-isoprostanes (p < .001), but had no effect on plasma carbonyls. The addition of LA to AT did not produce an additional significant improvement in the measures of oxidative stress. In conclusion, LA supplementation functions as an antioxidant, because it decreases plasma- and LDL-oxidation and urinary isoprostanes."

http://www.ncbi.nlm....pubmed/10569644


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 Posted 8/17/2012 10:02:32 AM
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I notice I lose weight easily when I'm taking one capsule a day. I do low carb too and exercise too. In the afternoon I take one capsule of C0Q10 too.
Does it happen to anyone else?

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 Posted 12/17/2012 9:40:11 AM
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I take LE's Mito EO 2-4 days a week as an overall energizing and cognitive support supplement based largely on the lipoic acid and acetylcarnitine, treating the rest mostly as a bonus.  It's a little on the pricey side, but the quality of ingredients (e.g. the R form and the arginate) and the "bonus" ingredients IMO justify it.
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 Posted 12/28/2012 10:50:58 AM
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I'm somewhat confused with the dosing recommendation of twice per day or all at once..which is it?.  LEF contends that 1000 mg of carnosine is necessary to overcome the enzyme that degrades carnosine.  If one splits the dose, does that render the carnosine ineffective at mitigating glycation?
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 Posted 1/3/2013 9:11:12 AM
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According to Product Development:

An individual does not need to take all fourcapsules together in order to protect against protein glycation, but it isideal to take enough carnosine to saturate the carnosinase enzyme (generallyconsidered 500 mg carnosine at a time) to make enough carnosine available tothe rest of the body.


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