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R- lipoic acid or R-dihydro-lipoic acid ???

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 Posted 12/14/2011 6:46:50 PM
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R-dihydro-lipoic acid =



1]As of now very few studies on human organs or in living animals available



2]No studies on; taken orally’ yet



3]No studies on its accumulative effect in moderation over time [which is wherethe r lipic acid gets so benefited



4]Admit that r-dhla in supplement form is very potent (but not necessarily benefiting);therefore even possible negative influence at interaction with cellular iron



5]weall always get anyways all out r-dhla efficiently by electrically reduce it andrelease it ;AND results shown to favor R-dhla over R-la may be just due totiming i.e. results obtained by supplement R-dhla is instant ,and from R-laonly after been converted to its reduction form



6]its the journey not destination it’s the mechanism the metabolic processconversion how results are obtained from consuming R-lipoic acid [mitochondrialpdh enzymes uses excess electrons from nadh that effects nad plus to nadh ratio]which we all miss at R-dihydro lipoic acid



Isthis assumption right or wrong???



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 Posted 1/18/2012 11:46:35 AM
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Are your questions about R-DHLA regarding a specific company's products (i.e. Geronova, who also sells the "Stabilized R-Lipoic Acid" raw material to supplement manufacturers, such as Life Extension)?

Geronova is the only brand that uses Dihydro Lipoic Acid in their products to the best of my knowledge.

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 Posted 1/25/2012 8:37:15 AM
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1. A medline http://www.ncbi.nlm.nih.gov/pubmed search of "lipoic acid" limited to human and animal studies retrieved 2,465 abstracts, however, a quick perusal shows that some of them involve human or animal tissue rather than live subjects. 

2. Limiting search results to human trials retrieved 162 results. 

3. There do not appear to be long term clinical studies.  This one http://www.ncbi.nlm.nih.gov/pubmed/17982894 had an observation period of 48 months, this http://www.ncbi.nlm.nih.gov/pubmed/10499773 describes a two year trial.

4. Scientistshave discovered that R-dihydro-lipoic acid exerts a number of antioxidant andneuroprotective actions that have not been seen with alpha-lipoic acid. Bothalpha-lipoic acid and R-dihydro-lipoic acid effectively scavenge a number ofradical species (hydroxyl radicals, nitric oxide radicals, peroxynitrite,hydrogen peroxide, and hypochlorite); however, only R-dihydro-lipoic acid hasbeen shown effective against superoxide and peroxyl reactive oxygen species. Inaddition, R-dihydro-lipoic acid has been shown to enhance the antioxidanteffects of CoQ10. By donating an electron to oxidized CoQ10, R-dihydro-lipoicacid has been demonstrated to prevent the formation of damaging pro-oxidants,while maintaining CoQ10 in its active antioxidant form to prevent peroxidationof susceptible biomembranes.

Iron hasdamaging pro-oxidant effects in the brain and may increase the risk forneurological conditions such as Parkinson’s disease. Researchers have foundthat neurons were significantly protected by R-dihydro-lipoic acid followingexposure to iron/hydrogen peroxide and amyloid beta-peptide. Interestingly,this effect was not seen in cells treated with alpha lipoic acid.

5. Alpha-lipoicacid, when administered orally, quickly crosses cellular membranes to entercells where it is rapidly converted into its reduced form, R-dihydro-lipoicacid (R-DHLA).  However, it makes more sense to take R-dihydro-lipoic aciddirectly because it is immediately usable, as the body does not have to convertit from alpha-lipoic acid.

6. NADH reducesalpha lipoic acid to R-dihydro-lipoic acid. DHLA in turn increases glutathionelevels which then helps to maintain healthy mitochondrial function.



 


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