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A powerful, natural, anti-cancer supplement

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 Posted 11/20/2011 2:51:39 PM
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A powerful, natural, anti-cancer supplement

Kinases are a type of enzyme used extensively to transmit signals and control complex processes in cells. PAK's are serine/threonine protein kinases (enzymes), that among other things, are required for the growth and migration of certain tumors. The PAK1 kinase has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization.

More than 70% of human cancers such as breast, prostate, and such require kinase PAK1 for their growth.  Neurofibromatosis is a genetically-inherited disorder in which the nerve tissue grows tumors (neurofibromas) that may be benign or may cause serious damage by compressing nerves and other tissues.  Melanocytes also function abnormally in this disease, resulting in disordered skin pigmentation and "cafe-au-lait" spots. The tumors may cause bumps under the skin, colored spots, skeletal problems, pressure on spinal nerve roots, and other neurological problems. It was shown previously that neurofibromatosis associated tumors require the kinase PAK1 for their growth.

Artepillin C (3,5-diprenyl-4hydroxycinamic acid) from Brazilian green propolis, and CAPE (caffeic acid phenethyl ester), from New Zealand propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of neurofibromatosis tumors.  Artepillin C suppressess tumor angiogenesis.

It is shown for the first time that both Artepillin C (green propolis extract) indeed blocks the PAK1 signaling selectively, without affecting another kinase known as AKT. Furthermore, it was confirmed that both Artepillin C (green propolis extract) and Bio30® (New Zealand CAPE propolis extract) suppress almost completely the growth of human NF tumor xenografts in mice.

These results suggest that both CAPE and Artepillin C based propolis extracts are natural anti-PAK1 remedies and could be among the first effective neurofibromatosis tumor therapeutics available on the market and could be potentially useful for the treatment of PAK1 tumors.

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References:

Phytother Res. 2009 Mar;23(3):423-7. Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7177-82. Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.



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 Posted 11/23/2011 5:27:30 AM
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Anyone with multiple myeloma using Laminine.  A product made from 9 day old fertilized egg whites, shark cartilage and sea vegetables?

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 Posted 11/25/2011 4:16:00 PM
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Tom: What sources of green propolis extract can you recommend? i.e. - what companies do you trust that offer a high quality green propolis extract supplement?

-colbyhouse
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 Posted 11/25/2011 5:21:30 PM
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i answered that question b4. I don't know where it is but you can find it. Try searching the forum using the key words propolis or apitherapy.

-Tom


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Anything worth doing is worth doing well.
If you don't stand for something, you will fall for anything
If everything seems under control you're just not going fast enough. - Mario Andretti
You can't expect to do business today, with yesterday's tools, and be in business tomorrow. - Author Unknown
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