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Optimal Folate intake and blood level

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 Posted 8/30/2011 4:35:24 PM
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I have read various articles claiming that you should take anywhere from 400mcg-5mg of Folate per day. The Folate blood test only shows up to ">19.9 ng/mL". For me it appears I only need to take 400mcg to reach that level. I might not actually need any supplementation at all, but that is how much is in my vitamin. Is there any benefit to taking an amount of Folate above an amount which would put your blood level at ">19.9 ng/mL" on the test, eg 800mcg when 400mcg already maxes out the test.

Anyone happen to know of studies showing that taking huge doses of Folate, that would put the level well above the top of the test, range to be helpful?


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 Posted 8/31/2011 3:24:17 AM
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Hi calc,
the trio folic acid, b6 and b12 help to lower high levels Homocysteine. Sometimes TMG is necessary, too.
So, the question is not the folate level himself, it is you HCY level which make it necessary to take more folate (and the others maybe too).
Additional to the simple folic acid (400 - 800 mcg) I think it is wise to take the bioactive form Optimized-Folate-L-Methylfolate Item No. 01439.
Let test your HCY level and take additional to your LEF  Mix or Complete B Complex L-Methylfolate.
HCY is a good example to show that only the correct supplementation (maybe the 4 b-vitamins in individually correct amounts) to get the desired
effect  (maximum lowered HCY level) to stay healthy.
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 Posted 8/31/2011 5:21:56 AM
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If your blood levels of B6, B9 (Folic Acid), B12, are all above the normal range, then I don't see how taking more them would help. Making sure to have enough Choline/TMG of course would help, and isn't something that is easily testable, as far as I can tell so far, at least no direct blood test for them.

My last results were:

B6 - >100.0 (5.3-46.7)
B9 - >19.9 (>3.0)
B12 - 1710 (211-946)

With respect to homocysteine, what is the difference between the homocysteine test that is part of the amino acid panel and the standalone homocysteine test? The one in the amino acid panel always comes back as 0.0 for me.
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 Posted 8/31/2011 5:41:15 AM
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Your results are fine.
Of course, HCY standalone test or part of amino acid panel make no diff.
Crucial only the result which should be <8.
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 Posted 8/31/2011 5:55:07 AM
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Well the normal ranges listed for them are different which is why I was wondering about it.

I think I will ask the lab about it when I get my next set of results back.
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 Posted 9/4/2011 8:45:46 AM
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Anyone happen to know of studies showing that taking huge doses of Folate, that would put the level well above the top of the test, range to be helpful?


Hello Calc! Have you tested your homocysteine? I personally do not feel comfortable with huge dose of folate with respect to RDA and still concerned about the potential increased risks of prostate cancer. There were discussions on this and the old forum already. You might also wish to check THIS and the studies therein.


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 Posted 9/6/2011 6:56:33 AM
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Thanks albedo, that thread is very interesting.
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 Posted 9/9/2011 1:54:03 AM
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I heard a naturopath, Anne Gittleman I believe is her name, is mega-dosing folic acid (around 5 mg) for menopausal concerns. I've never heard for sure of high-dose folate supplementation advocated for a man. Seems like I've heard of people treating depression with above-RDA folate; but you'd want to do a lot of testing and be sure that's what you should be doing.

I got an LEF e-mail recently about how in a recent study risk for colon cancer, the cancer of most concern with folate, correlated negatively rather positively with higher folic acid.


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 Posted 9/29/2011 10:28:15 AM
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I looked into it some more and I am going to have the rbc folate test done. From my other test results it looks like my DHFR gene might not be functioning very well so it may be worthwhile taking Folinic instead of regular Folic Acid. The last time I had my Homocysteine test done was about a year ago but it was 6.7 which seems reasonable if not ideal (<6.3), and would seem to imply I don't have the MTHFR defect, and my dna results don't show any matching snps for that problem.

DHFR also apparently regenerates BH4 which some of my results seem to point towards that possibly be deficient, which is one of the reasons I think DHFR might not be working well. Also 11 out of the 12 snps tested for in that gene were hetero or defective, though apparently defects in DHFR are not currently well known.
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 Posted 10/6/2011 5:46:08 AM
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My RBC Folate level came back surprising high, especially for only 400mcg intake, like there may some sort of block in using it. Since I started taking Folinic I've been losing weight each day, if it continues it may be that I had the DHFR issue combined with some other Folate use issue. My wife's levels were even higher but as soon as she started Folinic her skin 'spots' cleared up dramatically. I'm not sure what the spots were, they looked like weird red blotches, but they weren't acne, and she has had them over the past several years.

One thing that was really odd was that the manual computation of RBC Folate = ((Folate Hemolysate * 21)/Hematocrit)*100 that I found online didn't even come close to the reported value of RBC Folate.

Folate Hemolysate 16.8
Hematocrit 46.7
Folate, RBC 1115

The computed value came up with only 755 for Folate, RBC, which is only 2/3 of the reported value.

My wife's values were:

Folate Hemolysate 15.8
Hematocrit 40.6
Folate, RBC 1206

Calculated 817, which is also 2/3 of the reported value, and actually exactly the same difference in percentage, 67.7% which seems odd.

Anyone happen to know why the values would be so divergent, and by the same percentage?
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