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 Posted 4/24/2011 11:04:17 PM
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Has anybody got experiences taking Melatonin. If so at what dosage level and how often?  I've read its probably not wise to take it long term, because it may cause your body to stop producing it naturally. I was thinking about taking it maybe 1-3 times a week for helping me get to sleep. (I work a night shift and find it extremely hard sometimes to go to bed when I get home in the morning-I figured melatonin might possibly help).

Also is it best to take instant release or sustained release?

Any thoughts?
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 Posted 4/25/2011 2:47:27 AM
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I take small doses (2-3 mg/week, hence an average of ~0.3 mg/d) not really as sleep aid but rather for its antioxidant and anti aging proprieties.

Here just few of the studies you can find on this, lot more into LEF's site:

The report concludes with the suggestion that melatonin, alone or in combination with other antioxidants, be considered for routine usage to potentially combat some of the neural ravages of aging.
http://p973.ccmu.edu.cn/4-zuixinjinzhan/3/PartV/2.pdf

Thus, melatonin has been shown prophylactically to reduce amyloid beta protein toxicity of Alzheimer's disease, to reduce oxidative damage in several models of Parkinson's disease (dopamine auto-oxidation, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine), to protect against glutamate excitotoxicity, to reduce ischemia-reperfusion injury, to lower neural damage due to gamma-aminolevulinic acid (phorphyria), hyperbaric hyperoxia and a variety of neural toxins.
http://www.ncbi.nlm.nih.gov/pubmed/9770244

While exogenous melatonin did not have any significant effect on the GSH levels of the different brain regions in the younger rats, it significantly increased in the aged group. Exogenous melatonin can prevent the increased production of age-related lipid peroxidation products and might have a potential role for retardation of age-related oxidative events.
http://www.ncbi.nlm.nih.gov/pubmed/18755164

Melatonin's function as a free radical scavenger and antioxidant is likely assisted by the ease with which it crosses morphophysiological barriers, e.g., the blood-brain barrier, and enters cells and subcellular compartments. Whether the quantity of melatonin produced in vertebrate species is sufficient to significantly influence the total antioxidative defense capacity of the organism remains unknown, but its pharmacological benefits seem assured considering the low toxicity of the molecule.
http://www.ncbi.nlm.nih.gov/pubmed/9194681


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 Posted 4/26/2011 6:32:17 AM
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Have used melatonin since the 90s with good results.  Sustained release may work better for many people since melatonin has a short half life.  Otherwise one can take an additional dose if one wakes up during the night.
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 Posted 4/26/2011 10:45:41 AM
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Be careful with melatonin...I think everyone has a different experience with the hormone.  The first time that I took it I had a relaxing and deep slumber, but every time I took it after that it did little to improve my sleep but left me very irritable and cranky the next day.  It took me about a month to figure out that melatonin was causing my irritability, but once I ceased taking it my normal mood immediately returned.   
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 Posted 4/26/2011 6:05:54 PM
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You might want to read the previous discussion on this topic HERE


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 Posted 4/27/2011 9:13:03 AM
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Thanks for all your responses

DDye, What is the dosage amount of melatonin do you take and do you  take it every night?
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 Posted 4/27/2011 9:15:09 AM
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Around 1 milligram is taken as needed.
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 Posted 4/28/2011 5:53:33 AM
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If you wake up feeling groggy, or as if you have a hang over, your dosage is too high and/or you didn't allow enough sleep time.  For example, if you take a proper dose, but get half the sleep time you need, you may wake up groggy.  If you take too high of a dose but get a long, uninterrupted sleep, you may still wake up groggy.  Accurate dosage and sleep times are important.


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Seize every opportunity to put your best foot forward.

Anything worth doing is worth doing well.
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You can't expect to do business today, with yesterday's tools, and be in business tomorrow. - Author Unknown
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 Posted 4/30/2011 3:46:00 AM
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I take between 300 - 600 mcg ! One capsule swallowed one opened and powder sprinkled onto my tongue.

It depends on if I have had any stimulants after 3pm. Ie a late coffee or even, heavens above a chocolate biscuit. I seem to be very sensitive to all stimulants these days.

I have found that generally females need less melatonin than males. My husband has taken 6mg a night and swears it has not made any difference to his sleep.

FlyingPud
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 Posted 5/2/2011 4:28:47 AM
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With melatonin, less is often more.  Some people get better results with a lower dose.
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