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How to reverse grey hair

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 Posted 2/18/2014 5:46:35 AM
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"Peptide TA-5" would be the name for a proprietary peptide. . . is it the same as Melitane® ? Anybody know?  Still trying to investigate the claims of the latter. . . here's a marketing brochure to download that is filled with textbook-style informative descriptions:
http://www.quetzalquimica.com/images/MELITANE%20marketing%20brochure_8.5X1127-08-2008.pdf



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Post #11938
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 Posted 2/19/2014 2:38:36 AM
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Just wanted to know. I started with the pseudocatalase shampoo in January, did it for three weeks and then I ran out of product ( I had ordered in the mean time but nothing has arrived yet). Today is my 4th day I'm not able to use it and I don't know when exactly it will arrive. Will a 1 week break mean that I have to start all over or the results will come in slower?

In the mean time I'm still taking the supps to decrease cortisol ( ashwagandha and fo ti)

I'm also looking out to see what melitame does. As it works to increase MSH it should also darken light ( non greying hair) My lashes are very pale naturally.
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 Posted 2/19/2014 5:33:45 AM
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@Ajanthony - No doubt that baking soda is powerful. I've used it to remove the acidic corrosion on car batteries, and some toothpastes contain it as well.  My guess is that it will not penetrate the skin (scalp) where the H202 accumulates. Maybe that is the the purpose  for adding the manganese chloride in the mixture of psuedocatalae

@DDye - interesting article on the D3. Thank you.

@Ladd - I agree on genetics being the far superior culprit of why one's hair grays. I know people who've smoked all their lives, and have maintained most of their hair pigmentation, and the same goes for alcohol. I know people who have never smoked, an their as white as the driven snow.

@psuedocatalase - I often see the Shallreuter treatment for vitiligo as pseudocatalase + calcium.  Do your products have the + calcium? Is it possible that rinsing the hair with a water/calcium chloride mix a few times per week could be beneficial for the results using pseudocatalase?
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 Posted 2/19/2014 6:58:00 AM
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@wisdom1st, yes, we provide calcium in Pc-KUS. I am uncertain about the CaCl2 rinse. 

@fastingly  Peptide TA-5 is not melitane, it is something else. Melitane would be acetyl hexapeptide-1.

@stefanovic, send an email, and we can track down when your product went out. 
  
For those curious about melitane, I think it has great potential. Alpha melanocyte stimulating hormone (Alpha-MSH) is the natural response to UVB exposure. It triggers multiple pathways both in the skin and centrally that relate to different things, including stimulating melanocytes. Alpha-MSH is a 13 amino acid peptide. Lucas Meyer isolated the binding sites as 4 amino acids in the 13 amino acid chain, modified these 4 amino acids into a 6 AA peptide, acetylated it, and tested it for binding and alpha-MSH-like activity in vitro and in vivo. You can bet they ran through a LARGE number of peptides in their efforts to find the smallest one that would work well. As such, it is, BY FAR, the best bet on the market for topical use. The other Alpha-MSH drugs are actually longer than Alpha-MSH (more than 13 amino acids), so their skin penetration would be worse. You would really need to inject them to see a response (which people seem to do, anyway). Kudos to Lucas Meyer, I hope it can help people with vitiligo and graying hair. 
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 Posted 2/19/2014 8:11:28 AM
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email has been sent ( @ pseudocatalase)


I saw another doctor today and he noticed that my B12, folic acid, copper and zinc havent been checked. The doctor I saw before was so into the cortisol story that she forgot about the rest ( that's truly what many doctors are like over here, they only hear what they wanna hear)
That's so typical. I bet many of you have been through the same kinda situations.

I hope some people ( also blondes to see the effect on lighter hair) can start with the melitame soon. 
Post #11954
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 Posted 2/19/2014 12:09:04 PM
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I monitored a small but very real benefit when I first started taking resveratrol a few years ago. Watching closely over time I noticed a regrowth of receding hair line of one quarter to one half inch and intergrowth of dark hairs turning white or solid gray areas into a salt and pepper mix. It was limited but real. I'm trying time release resveratrol next along with pterostilbene. A renewed change effect would be welcome.

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 Posted 2/22/2014 9:41:13 AM
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A VERY OLD (1967) paper regarding MELITANE active ingredient MSH:

http://www.nature.com/jid/journal/v49/n3/full/jid1967143a.html

"Effect of the Alpha Melanocyte Stimulating Hormone on Mammalian Hair Colors1

David Clive and Richard Snell MD, PhD

1 From the Section of Dermatology, Department of Medicine and the Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut

Received 12 April 1967.


SUMMARY(1) The effect of clipping and MSH on hair color has been studied in mature male guinea pigs.

(2) Hair samples were obtained from the scalp and anterior abdominal wall at monthly intervals for 3 months. The hairs were mounted on slides and hair color counts were performed.

(3) Clipping increased the proportion of dark to light colored hairs in the majority ofMSH AND HAIR COLOR321the animals and this effect was seen to be greatest in the scalp of the red animals and the anterior abdominal wall of the black animals. In a few of the animals the opposite effect was noted.

(4) Alpha MSH increased the proportion of dark to light colored hairs, and this effect was greatest in the black animals.

(5) It was concluded that the process of clipping can influence follicular melanogenesis and that alpha MSH stimulates melanogenesis in a manner similar to that seen in epidermal melanocytes."

Strange that it took almost 50 years to  come up with a anti gray hair product based on MSH ...

TO LEF :

LEF sells cosmetics. Why not developing a anti gray hair shampoo combining MSH, pseudocatalase, etc. ? It would be a blockbuster and could boost LEFs cash flow enormously ... What do u think ?



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 Posted 2/22/2014 12:14:24 PM
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Maybe Sodium Bicarbonate in water mixed with two parts DMSO to carry it thru the epidermis might work. Had an associate who used to swear by it for toothaches.
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 Posted 2/22/2014 3:33:14 PM
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(4) Alpha MSH increased the proportion of dark to light colored hairs, and this effect was greatest in the black animals.

This means it should also darken light ( non greying) hair so it could help darkening very pale eyelashes too. Could be a good thing for me and some others as well.
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 Posted 2/23/2014 7:05:39 AM
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hi Zeno,

Your request has been forwarded to Life Extension's Product Development Department.

D Dye
Moderator


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