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How to reverse grey hair

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 Posted 11/10/2013 5:19:49 AM
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If I'm not mistaken, Dr Karin merely speculated pseudocatalase might reverse grey hair.  What has been established is that it helps with vitiligo. 

There have never been peer-reviewed studies  (or even a single study) on psedocatalase and grey hair. 

Unfortunately, the low-life scammers twisted Dr Karin's study on vitiligo and the speculation that it MAY (not WILL) work for grey hair and made a fast buck on a lot of desperate people.

If you disagree with this, then provide the link to the peer reviewed medical journal that has a study on pseudocatalase and grey hair.

Or, provide a link to a pseudocatalase product that has been proven to reverse grey hair in dozens of people with before and after photos.

There is no such product.  If there was, they wouldn't be selling it on eBay with a kitchen-made label and they wouldn't be taking down negative consumer reviews or operating out of their home. 

Maybe pseudocatalse can help reverse grey hair.  But so far, no one has proven it.
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 Posted 11/10/2013 8:19:46 AM
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Couldn't agree more StarGazer2
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 Posted 11/11/2013 4:47:07 AM
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Truth and Beauty, welcome to the Forums.

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 Posted 11/11/2013 5:52:19 AM
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@Stargazer - Shallreuter's journal stated that eyelashes regained pigmentation when employing PC-KUS.

"For generations, numerous remedies have been concocted to hide gray hair," Dr. Gerald Weissmann, editor-in-chief of FASEB Journal, said in a statement. "But now, for the first time, an actual treatment that gets to the root of the problem has been developed."

That would be pretty ballsy for him to speculate and risk losing such a prestigious position, along with damaging his reputation. I would think he has more insight than anyone on this forum.

Our own Pseudocatalase(forum member), has delved into Shallreuter's work.  He has claimed that reversing gray hair is not only possible, but his subjects have actually had some success. He said that success is greater restoring pigmentation in vitiligo patients when hair follicles are present in those areas.  Of course he has something to gain because he is selling a product, but he has been upfront, and has responded to every question he has been asked.

Any help here Pseudocatalase would be appreciated.

I am providing a link to an article that I found interesting

http://www.uvornotuv.com/pdfs/PC-KUS.pdft 
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 Posted 11/11/2013 6:24:33 AM
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Hi, Pseudocatalase. I have some questions.

First, a little about myself.

I'm 25 years old. I first started getting random white hairs (1-2) about 3 years ago. Currently, my hair is < 1-2% gray/white. However, it is progressing, albeit very slowly.

Graying under the age of 35 does have a negative psychological effect. It's not ruining my life, but it is a stressor, especially as a young single male. If I could stop the progression or at least slow it down by many multiples I would consider that a success.

Questions:

How common is the growth of "light hair" if one has dark hair naturally? (I haven't been blond since I was 6 years old).

What is the shampoo made of? Is it just a "raw shampoo" with nothing in it? I can't use regular shampoo. It drys the hell out of my scalp.

What do you think would happen if I use it 2-3 times a week? Remember, I'm only trying to stop or greatly stall the progression. In theory it should be enough to immediately halt any further build up of hydrogen peroxide and over the long term possibly lower the levels, right?
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 Posted 11/11/2013 7:16:11 AM
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StarGazer2 (11/10/2013)
If I'm not mistaken, Dr Karin merely speculated pseudocatalase might reverse grey hair.  What has been established is that it helps with vitiligo.


Vitiligo and gray hair have similar biological causes (although it's possible there are more that haven't been found), so while it is speculative, it's definitely not a gigantic leap of faith. It appears that gray hair can be treated cosmetically and it's a far easier problem to solve than balding.

StarGazer2 (11/10/2013)
There is no such product.  If there was, they wouldn't be selling it on eBay with a kitchen-made label and they wouldn't be taking down negative consumer reviews or operating out of their home.


There are no products because the research and theories are essentially brand new. The pseudocatalase/gray hair thing hit back in May? Not long ago at all. I personally think we're on the brink of a mass marketed treatment (1-3 years). L'Oreal filed their patent back in 09 (which was magically "stumbled upon" by the press back in June). It takes many years to get a product from development to shelves. Could you imagine if they released something that left people bald or with green hair after a year of use?

Also, in fairness to Pseudocatalase (the forum member) he has been pretty transparent. I wouldn't box him in with the rest as he has never claimed the possession of some "miracle cure", just that it MIGHT work and him and his colleagues are testing it (although I do wish there was even more transparency, i.e. photos with the testing). 

I wouldn't be surprised if psueodocatalse does work, but doesn't reverse gray hair completely. It could be a product that stops/prevents graying and MAYBE reverses it. The level of effectiveness is probably determined by age, health, and amount of time already spent graying. We just don't know.
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 Posted 11/11/2013 7:25:03 AM
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@ladd, it seems fairly common, but that was during summer months. Seems to be darkening now. The shampoo is a very basic shampoo with ingredients chosen so that they will not react with the pseudocatalase. If you cannot use most shampoos, then you will likely not be able to use it. For using less frequently, I don´t recommend it. Hydrogen peroxide is created by skin cells on a fairly regular basis. It is a natural part of the immune response of skin cells, and serves to attack invading bacteria as well as signalling macrophages to infiltrate. If you used the shampoo every 2-3 days, I think the effect would be greatly diminished. 

@wisdom1st, yes, we have seen success in multiple people. The rate of restoration of pigment is pretty comparable to that in vitiligo, which is to say very slow and patchy. It´s not like you start using the shampoo and hair starts growing in dark at the root immediately. Instead, some gray hairs get pigmented in the first month, and each month thereafter a small percentage of white hairs restore pigment (in all honesty, it is probably close to 5% of the white hairs each month). It is a frighteningly slow process, which is no different from vitiligo (Schallreuter spent her career begging people to be patient enough to let the process take its course).  

I know people want to see more photos, and we will post some each few months, but the rate of restoration is slow, and it is quite easy for a skeptic to claim we are trying to manipulate lighting etc. The real truth is that the people using it who have seen effects are quite confident that it works, but that it works slowly. 
  
I think we´ve been clear in this forum about the rate of return. We also expect that as some factors that contribute to graying of hair are different from vitiligo, we cannot be certain that 100% pigmentation is achievable. The hair follicles are also reacting to overall inflammation level (cytokines, corticosteroid levels, etc), and these are not going to be impacted by the use of pseudocatalase. But, if you want to use the shampoo and see if some small percentage of natural pigment returns in the first 3-4 months, that is what we are after. 
Post #10896
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 Posted 11/11/2013 8:13:00 AM
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"So at least some of the Depo M is actually bubbling...but it seems like just some of the recent stuff?? What were they thinking?? 

And even with doing the peroxide tests how can we know that it will actually reverse gray hair anyway?? Surely we should have been seeing SOME positive results by now?? I have pretty much lost hope because i think it is impossible to reverse!!"

Romi's post was very interesting and he raises some excellent points. In my mind (and being an engineer who likes to deconstruct a problem) there are two very big hurdles to overcome with both vitiligo and gray hair treatment:

1) Expiration of the active compound. This obviously affects every product we've been testing thus far and apparently each one available appears to suffer from rapid expiration (depending on the containing media of course). And the carrying media you often expect to work can render the compound inert. For example - I just ordered the eBay product from pseudocatalase and mixed it with distilled water. Turns out that's the worse you can do as water dilutes it and renders it completely ineffective after a few days. Not what you would expect and even J (the guy who sells it) was surprised when replicating the experiment. So we need to constantly test - every other day is probably recommended.
2) Skin penetration. It's very much possible that some of pseudocatalase compounds may test out well in vitrio but are unable to properly penetrate the skin - perhaps due to molecule size or other bound components. This is something that will be extremely difficult to test unfortunately and is outside the realms of home experiments. 

If both problems can be addressed then I think a viable treatment has very high odds of working.
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 Posted 11/11/2013 9:50:00 AM
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Pseudocatalase (11/11/2013)
@ladd, it seems fairly common, but that was during summer months. Seems to be darkening now.


For clarification. What about the already naturally fully pigmented hair? Does that change color too?

TBH this is the biggest obstacle for me. I don't want my good hair (99%) to change (start growing noticeably lighter), BUT I'm willing to take a risk if I can slow or prevent the process. 

Pseudocatalase (11/11/2013)
The shampoo is a very basic shampoo with ingredients chosen so that they will not react with the pseudocatalase. If you cannot use most shampoos, then you will likely not be able to use it.


Thanks. I shave my head (3/8th inch), so I can get away with using some sort of lotion (rinse out) or conditioner. If I buy some I will try to find something that has a similar consistency to shampoo/lotion, can be used regularly, and doesn't react with the pseudocatalase.

Pseudocatalase (11/11/2013)
For using less frequently, I don´t recommend it. Hydrogen peroxide is created by skin cells on a fairly regular basis. It is a natural part of the immune response of skin cells, and serves to attack invading bacteria as well as signalling macrophages to infiltrate. If you used the shampoo every 2-3 days, I think the effect would be greatly diminished. 


I'm familiar with the production of hydrogen peroxide. My reasoning is this: If hair X is pigmented 100% brown it would mean the H2O2 within hair follicle X has not reached levels capable of causing damage. We know the build up of H202 is a slow and gradual process and apparently so is removing it. Thus, in theory, if you have a bunch of hair like hair X, then you would only need to remove H2O2 as fast as it is produced? There is some sort of H202 "line". Above you get gray, below your hair repigments. We go gray because the natural H202 removal mechanisms slow down or stop completely (within the hair follicle)? I can't help but think that preventing gray hair with pseudocatalase is easier than reversing gray hair, especially since we have no idea what other damage H202 build up causes in the hair follicle. It may cause damage that can only be fixed with drugs which is why hair may not repigment fully with pseudocatalase alone (unfounded speculation, too early to tell, but possible). So, in summary I figure the amount needed to have a "prevention" effect would be less than a "reversal" effect. H202 should never reach a level that causes damage if it's consistently being "squashed down"?

What is the youngest age of the person you have using it for gray hair? What % of hair was gray? Is there any difference in effectiveness in comparison to the oldest participants?

Pseudocatalase (11/11/2013)
I know people want to see more photos, and we will post some each few months, but the rate of restoration is slow, and it is quite easy for a skeptic to claim we are trying to manipulate lighting etc. The real truth is that the people using it who have seen effects are quite confident that it works, but that it works slowly.


I don't think you'll face anywhere near as much skepticism as you think. You've been completely honest since you started posting here (awesome). I know the first photos you posted were met with some negative skepticism, but I could see the color change, it was clear. I personally never expected a man, whom I assume is 45-55 years old, would suddenly start sprouting perfectly pigmented hair. I'm sure most would here would agree.
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 Posted 11/11/2013 3:18:20 PM
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I trust Aussie David.  He (along with a few others of us here) go back to the original LEF board.    We've been here for 10 years. 

Pseudocatalase  - you said here if it doesn't work after 8 weeks, you would recommend that the user stops (which at that time added to your credibility).   So are you now telling those like Aussie David not to re-order when they are saying it's not working for them?    Or are you now telling customers it will take a long time? 

You were definitive before about the timeline for results.  

And multiple people could be 2 users. 

How about putting your product on Amazon where people can review it?  If you're that confident in your product, that would certainly be worth a lot more sales (or kill them).  Amazon has a way of shedding light on product quality.

************************

I said pseudocatalase might reverse grey hair but there is no product that has been proven to work.  

Amazing how logic gets twisted around here when you're living in the land of wishing and hoping.

"We have proof pseudocatalase products works because sellers are telling us it does.  And we believe it does because we wish real hard it does."  

I also said there have been no independent peer-reviewed studies showing the effectiveness of pseudocatalase and grey hair (meaning scalp hair).   Many vitiligo sufferers have lost pigmentation of eye lashes.   Yes, it works for vitiligo.

************************

This board has a long history of sellers who have come here and hawked their products.  Every one of them to date has been unable to come up with a product that works to the satisfaction of the users here. 

Newbie board posters aren't going to speak for the grizzled (pun intended) veterans.   If you don't like my skepticism, tough. 

I'll serve as the only watchdog if I have to.   This is the best grey hair forum because it's the toughest dogpound on claims. 
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