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How to reverse grey hair

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 Posted 6/14/2014 6:23:38 AM
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Romi (6/13/2014)
@Gaizz

Have you performed the H2O2 test on Plus Tricomelan ?
Now... After 10 minutes, NOTHING...Sad

jamieh (6/13/2014)
Which one has 4%?
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 Posted 6/14/2014 11:40:04 AM
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It's good we're all trying a different melitane product. It should work after 2-3 months. The piz buin products contain melitane with carriers for skin darkening so with the right carrier for hair ( I'm using DMI) it is supposed to work.
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 Posted 6/16/2014 6:07:54 AM
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@stefanovic

I'm not sure the results will be gradual. It's a stimulant. Stimulants are instantaneous and have a ceiling. Imagine a graph that shoots straight up and then runs horizontal.

Last week I asked if you would be willing to share your before and after photos but you never responded. If you put up your photos from October and then your most recent ones it would be awesome. From there we can follow your progression into melitane in a really transparent and helpful way.

Looking forward to your results and hope it works out for you.
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 Posted 6/17/2014 4:27:17 AM
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@Ladd, it is a stimulant, sort of. In our preliminary tests, melitane accelerated changes in hair color, but was no panacea. Certainly some users that barely respond to pseudocatalase responded substantially to pseudocatalase plus melitane. Our best responding user to pseudocatalase responded only modestly better to pseudocatalase plus melitane.  
  
Our best understanding of this process remains. Hydrogen peroxide, inflammation, and skin cortisol lead to destruction of melanocytes. Pseudocatalase blocks hydrogen peroxide dependent destruction of melanocytes. A very slow replenishing process occurs that restores some color, and this process is boosted by UVB exposure, or use of alpha-MSH agonists like acetyle hexapeptide-1 (melitane). Hitting both pathways is better than hitting one in all users, but no one should expect to eradicate all their gray hair using this approach. Most people will get a quite noticeable difference in a year, and should start seeing changes in 3-4 months.  
  
The other issue is melitane users will have to tolerate a nice, healthy, brownish, natural looking tan (of the skin) that occurs from its daily use for more than 3-4 weeks. 
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 Posted 6/17/2014 7:03:50 AM
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@Pseudocatalase

Really interesting. Thanks for sharing your findings.

"Hitting both pathways is better than hitting one in all users, but no one should expect to eradicate all their gray hair using this approach. Most people will get a quite noticeable difference in a year, and should start seeing changes in 3-4 months."

Has anyone hit an obvious ceiling of reversal? Is there still a possibility of complete reversal over 1.5-2.5+ years?

Also, is there any risk in using an alpha-MSH agonist? Stimulating replication with something artificial is kind of scary at first glance.
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 Posted 6/17/2014 12:59:22 PM
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@Pseudocatalse:

Can you give your thoughts on what a good penetration carrier for Melitane could be? What are your thoughts on DMI for this?
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 Posted 6/18/2014 4:01:24 AM
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I have deleted those pics, just didn't want anything to remind me of that grey period.
At the moment my hair is dyed. I went to have a haircut 5 days after I had dyed it and the hairdresser already saw my roots. I don't understand why people say hair dye is a solution, you just have to re-dye it every 6-8 weeks.

I'm currently using the melitane with DMI as a carrier. Started using it last thursday so way too early to see any results.
I wonder if the MSH agonist are similar to melanotan. When I was on melanotan, I noticed hair darkening, also dose depending.

There was also a brand new pubmed article released on kudzu beans, I just can't read the contents: http://www.ncbi.nlm.nih.gov/pubmed/24924521?dopt=AbstractPlus

Lots of claims about kombucha tea are found online. I don't think scientific research has been done on this, but it also doesn't mean it cannot work.
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 Posted 6/18/2014 8:34:28 AM
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The original kudzu study as a refresher:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662917/

I think the new study (no access) is based off this excerpt from the old one:

"In addition, our unpublished data indicate that the extract from P. lobata promotes the expression of MITF and melanogenesis in vitro, and its topical application prevents hair graying in MITFvit/mi mice (Park, 2012, unpublished data)."

They probably go much deeper into HOW/WHY kudzu works.

Kudzu + PC-KUS is probably worth investigating.
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 Posted 6/18/2014 9:47:16 AM
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Do the tricomelan folk ship outside of Italy?
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 Posted 6/19/2014 10:03:24 AM
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This is of interest, if only in regard to its mechanisms http://www.nature.com/jid/journal/vaop/ncurrent/abs/jid2014202a.html

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