Life Extension Forums




DHEA supplementation

Author Message
 Posted 3/19/2011 3:42:25 AM
Forum Associate

Forum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum Associate

Status: Member
Group: Contributors
Last Login: 12/16/2014 11:30:19 PM
Posts: 1,666, Visits: 2,470
blessed health (3/18/2011)
The Importance of Glutathione- I would like your opinion on this antioxidant that is known to increase you DHEA BY 46%/ Increase IGF-1 BY 41%/ and Decrease Tumor Necrosis Factor by 37%.

Appreciate your comment.

Can you point us to the study?
Post #1918
Add to Twitter Add to Facebook
 Posted 4/17/2011 12:47:09 PM
Forum Associate

Forum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum Associate

Status: Member
Group: Contributors
Last Login: 12/16/2014 11:30:19 PM
Posts: 1,666, Visits: 2,470
Interesting study:

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002025

"...Therefore, the current study meta-analyzed the results of genome-wide association studies (GWAS) performed in a total of 14,846 individuals from seven cohorts to identify common genetic variants associated with serum DHEAS concentrations. The findings not only advance understanding of how serum DHEAS concentration is regulated by genes but also provide clues as to its mechanism of action as well as Mendelian randomisation principles [26]....

... In summary, this first GWAS identified eight independent SNPs associated with serum DHEAS concentrations. The related genes have various associations with steroid hormone metabolism, co-morbidities of ageing including type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc fingers - suggesting a wider functional role for DHEAS than previously thought."


Tags:
Post #2176
Add to Twitter Add to Facebook
 Posted 5/23/2011 4:06:35 AM
Forum Associate

Forum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum Associate

Status: Member
Group: Contributors
Last Login: 12/16/2014 11:30:19 PM
Posts: 1,666, Visits: 2,470
Interesting study on DHEA effect on cognition (but i am afraid dose is too high IMO for longer term usage):

"...Conclusions: DHEA treatment improved memory recollection and mood and decreased trough cortisol levels. The effect of DHEA appears to be via neuronal recruitment of the steroid sensitive ACC that may be involved in pre-hippocampal memory processing..."

However, note also the cautionary statement:

"...The potential therapeutic implications of these findings need to be considered with considerable caution. Firstly, it is difficult to extrapolate the current positive effects of DHEA on memory and mood from this study in young healthy individuals to an elderly population with memory impairments. The current study investigated the effects of supraphysiological doses in a population with high baseline endogenous DHEA concentrations. It is unclear what dose would be required to produce similar effects, if these are possible, in a population with lower baseline DHEA concentrations. Secondly, the use of such high doses of DHEA as used here over the long term, could theoretically lead, via metabolism into active sex steroids, to adverse 548 effects, such as enhanced hormone-sensitive tumour growth (Wolkowitz et al. 2003). As a result, future investigations need to proceed with caution. This is despite a report that DHEA administration at pharmacological (but not physiological) concentrations inhibits angiogenesis, which is implicated in the pathologies of neoplasm, both in vitro and in vivo (Varet et al. 2004)..."


 Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men- a double-blind, placebo-controlled study (1)-1.pdf (7 views, 357.62 KB)

Tags:
Post #2537
Add to Twitter Add to Facebook
 Posted 5/29/2011 9:24:07 PM
Spectator

SpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectator

Status: Regular Customer
Group: Forum Members
Last Login: 5/29/2011 9:28:04 PM
Posts: 1, Visits: 40
Hi there, 

I'm a newbies here. This post is regarding to the DHEA+ IVF for women.

My wife been advised by the doctor to take up the DHEA of 100mg for twice a day + with Omega Q10 to increase the possibility of egg for fertility.

My concern are as below:

1. Anyone try with the above doses beofre? My wife at the age of 32.
2. Any side effect for the DHEA 100mg for twice a day?
3. The duration recommended by doctor for the DHEA is 3 months.

After the above, only doctor will advice us to continue our IVF. We did once before but there are only 1 egg which is successfully become an embro, so doctor would like us to take the above before we try out our 2nd IVF.

There are so many brand in the market for DHEA, anyone try any brand which is good? 

Hope to hear from you all. 

Appreciate for your reply


Tags:
Post #2633
Add to Twitter Add to Facebook
 Posted 5/31/2011 5:13:18 AM
Forum Coordinator

Forum Coordinator

Status: LE Employee
Group: Managers
Last Login: 14 minutes ago
Posts: 2,004, Visits: 7,452
Welcome tbchiang.  Further information on DHEA restoration therapy, including possible side effects, can be found at http://www.lef.org/protocols/metabolic_health/dhea_restoration_01.htm  

Life Extension has carried DHEA capsules for years.  See http://www.lef.org/Vitamins-Supplements/Anti-Aging-Longevity/Health-17000-1/Hormones.htm for a list of the DHEA supplements available. 

D Dye
Moderator


Tags:
Post #2639
Add to Twitter Add to Facebook
 Posted 6/5/2011 6:29:04 AM
Spectator

SpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectator

Status: Regular Customer
Group: Forum Members
Last Login: 6/5/2011 6:50:46 AM
Posts: 1, Visits: 4
New here first time post .  I have a question. I hear taking DHEA supplements causes hair loss in men is this true ? I have hair loss and don't want to take it if DHEA is going to worsen my hair loss problem .
Post #2688
Add to Twitter Add to Facebook
 Posted 6/6/2011 7:43:25 AM
Forum Associate

Forum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum AssociateForum Associate

Status: Member
Group: Contributors
Last Login: 12/16/2014 11:30:19 PM
Posts: 1,666, Visits: 2,470
I would first check if I am deficient in DHEA and take a full blood test including hormonal status. LEF offers a great and convenient panel if you are located in the US.
Post #2700
Add to Twitter Add to Facebook
 Posted 6/6/2011 10:10:30 AM
Advocate

AdvocateAdvocateAdvocateAdvocateAdvocateAdvocateAdvocateAdvocateAdvocate

Status: Member
Group: Forum Members
Last Login: 1 hour ago
Posts: 86, Visits: 8,078
I have been taking DHEA supplements for over 15 years and I have not experienced any hair loss from it.
Post #2701
Add to Twitter Add to Facebook
 Posted 6/6/2011 11:03:28 AM
Forum Coordinator

Forum Coordinator

Status: LE Employee
Group: Managers
Last Login: 14 minutes ago
Posts: 2,004, Visits: 7,452
Hair loss is a possible side effect if DHEA converts to testosterone which in turn converts to dihydrotestosterone in a quantity sufficient to increase alopecia.  This doesn't happen for the majority of men and women who use DHEA.  If it happens to you, you could try using it with a 5 alpha-reductase inhibitor, such as beta-sitosterol. 
Post #2702
Add to Twitter Add to Facebook
 Posted 6/29/2011 7:49:23 AM
Spectator

SpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectatorSpectator

Status: Expired Member
Group: Forum Members
Last Login: 6/29/2011 7:43:16 AM
Posts: 1, Visits: 2
do you have a list of qualified practioners ?
Post #2919
Add to Twitter Add to Facebook


Similar Topics

Expand / Collapse

Reading This Topic

Expand / Collapse