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new molecule to switch off appetite found - sodium acetate

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 Posted 5/13/2014 9:01:23 AM
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About 2 weeks ago, I ran across this link:

http://www.telegraph.co.uk/science/science-news/10796569/Pill-to-switch-off-hunger-possible-as-anti-appetite-molecule-discovered.html

Dug out the journal paper in Nature behind this article here:

Dietary fibre acts on brain to suppress appetite

http://www.nature.com/news/dietary-fibre-acts-on-brain-to-suppress-appetite-1.15127

and

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

http://www.nature.com/ncomms/2014/140429/ncomms4611/full/ncomms4611.html

This research seems to indicate that certain types of fiber (inulin), in fruits and veggies, that during digestion in the colon by (unspecified) bacteria results in the release of the acetate ion into the bloodstream.  The acetate ion finds it's way to the hypothalamus region of the brain where hunger is controlled, and switches off the hunger.

I tried this myself:

Well, if one mixes vinegar and baking soda (acetic acid and sodium bicarbonate), a violent reaction ensues with lots of fizzing as large amounts of CO2 are evolved.  When the reaction is finished, sodium acetate is what is left over (byproduct).

Sodium acetate and sodium diacetate are used in food to impart a "salt and vinegar" taste to chips, etc.  So it is safe to eat, at least in 2-3 gram quantities.

I started off mixing vinegar and baking soda (about 1 TBSP). Slowly added vinegar until no more CO2 was produced, so I had sodium acetate dissolved in water.  I did not boil it out to dry it first, but just diluted the liquid and drank it.  It tasted like salt and vinegar potato chips (without the chips).  It did a huge suppression on my appetite for about 36 hours. I had no hunger whatsoever.  I was not sick or nauseated.  I still ate what food I needed to ok. A rough estimate of this dose is probably roughly equal to the original volume of baking soda, or about 1 rounded TBSP.  No wonder it knocked out appetite for 36 hours!

I bought a 6lb can of "sodium acetate FCC"  (food grade) for about $30, nearly a lifetime supply. Buying food grade sodium acetate is much cheaper and much less hassle than making sodium acetate from vinegar and baking soda.

Day two, I took none, appetite slowly returned 1/2 way through the 2nd day.  3rd day I took about 1/2 gram, but still had some hunger. Increased to about 1 gram next day, more appetite surpression, but a little hunger. Now, I am back up to the two-three gram range (1/4 - 1/2 rounded TSP approx), and it is working pretty well.  This is probably similar to the amount one would get by eating a large double bag of salt & vinegar chips.

I read elsewhere that a .1 molar solution of sodium acetate has a pH of 7.8 - 8.9, depending on how much CO2 is dissolved into the water used to make up the solution.

The first day seems to have a much more pronounced effect, and then more is needed later on.  Also, I chewed up and swallowed some of the undissolved crystals, and did not have any irritation of the esophagus or stomach.

LEF might want to investigate putting this into a pill as a product?

I also take LEF "Advanced Anti-Adipocyte Formula" (product 01509), and lots of other LEF supplements, cinnamon, tri-sugar shield, etc.  It is possible these may multiply the effect of the sodium acetate.

Food grade (FCC) sodium acetate is readily available on the internet, for about $5 per 1lb jar, and $30 for 6 lb jar.  Also 50lb bags avail.  My weight loss rate has increased, and health seems normal.

--ghg


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 Posted 5/14/2014 5:03:22 PM
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Fascinating ghg2, thanks. I've been experimenting with this over the past 24 hours ever since I read your post.  I concocted my own "brew" and have been sipping what I roughly calculated to be about 3 grams sodium acetate based on the reagents of baking soda and vinegar used.
It certainly had the immediate effect of ruining my appetite Wink   . . .
I'm experimenting by eating only 500 calories in 36 hours to observe what happens. So far, the effects have been immediate, like I said, but not long-lasting at all, but still experimenting.
In the past, I've had great success with using large amounts of inulin fiber to decrease appetite, but the problem with flatulence is so great that the idea of this instead was certainly a welcome one!  



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 Posted 5/15/2014 4:27:26 AM
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fastingly, zinc, particularly zinc lozenges, and niacin have been used by some to suppress appetite. Also, having more excitement in one's life can divert attention from thoughts of food. (Not always easy to create, and one would want only excitement of the positive kind.) There are also subliminal CDs available to use for this purpose. Don't know how well they work.

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 Posted 5/16/2014 2:31:23 PM
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Well, my aforementioned try using the (vinegar+baking soda--> sodium acetate) solution was kind of interesting. My appetite was held at bay so long as I took many little sips of the beverage mixture every half hour or so, amounting to having at least double the amount suggested by ghg2.

There is likely more at play with fiber fermentation in the gut than just acetate, butyrate is another byproduct showing similar action. I'm hesitant to implement this into any long-term strategy of calorie restriction at this point, but it was worth a try.

DDye, I agree with you on the ideal approach to suppressing appetite.  I've trained myself over the past several years to compress my daily eating into a 6-hour window and regularly skip an entire day of eating with no problem.  But even with that, I still only manage to eat just exactly as many calories as my hypothalamus (mistakenly) thinks I need.  I remain at the opposite end of "normal" in bodyfat from where I would ideally prefer it to be. Calorie restriction remains an elusive goal and appetite is a ferocious beast to tame.



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 Posted 5/16/2014 5:13:36 PM
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Once attended an AIDS benefit buffet dinner.  Was loading up my plate when one of the patients in a wheelchair said to me "We wish we could eat like that." It made me thankful to have a healthy appetite.

My choice is to eat less than most Americans but not to be uncomfortable (unless doing something else that completely takes my mind off it).


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 Posted 5/17/2014 12:48:44 AM
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Fastingly, that is a great idea to add sodium acetate to a "water bottle". This solves several issues.  Sodium acetate is an anti-microbial, used in food preservation. A large single oral dose, could make it down to the colon and kill off beneficial microbes.

Secondly, water bottles are a problem, since bacteria starts to grow in them. I used to put a metal silver ribbon inside my water bottle to kill bacteria. I works for a few weeks, but iron, lime in the water eventually coats the strip rendering ineffective unless it is somehow cleaned off.  Sodium acetate in the water bottle should keep anything from growing in there.

Thirdly, sipping as needed, provides a time released type of solution that is easily tailored to individual needs.

--ghg
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 Posted 5/18/2014 1:03:13 AM
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All this sipping.........what could it do to teeth?
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 Posted 5/18/2014 9:52:21 AM
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Sipping would only kill mouth bacteria.  Since the solution is slightly alkaline, it will not erode teeth. Drinking Cola is very acidic and dissolves teeth.

--ghg
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 Posted 5/20/2014 12:16:35 AM
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Sodium acetate continues to work well for me.  1/3 to 1/2 TSP.. seems to kill hunger for about 5 hours now.

I would imagine that all of the acetates of sodium, potassium, calcium, magnesium, etc, and mixtures thereof, would have some effect.  This opens up a major new research area.  Being able to produce "optimum" supplements, without overloading on a certain ion (e.g. sodium). 

This opens up the field to have real "Diet drinks", that turn off your hunger.  Current mainstream "diet drinks" are loaded with aspartame, which has several negative effects like nerve damage, possible links to cancers, and making you gain weight, since they induce you to eat much more after consuming them.  Carbonated drinks also greatly acidify your body as well.  Sodium acetate is mildly alkaline, so it will not acidify.

--ghg
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 Posted 5/23/2014 6:06:28 AM
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The curious thing I'm wondering here is that alcohol yields tremendous amounts of acetate as it metabolizes in the body, yet alcohol is notorious for causing a stimulus in calorie intake--beer-belly anyone?-- (excepting with alcoholics where if metabolism is geared principally towards alcohol it causes appetite inhibition).


Hmmm. . .



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