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Benfotiamine: good or bad ?

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 Posted 6/15/2011 9:56:20 AM
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In reply to triplecrown, your question has been forwarded to Dr Michael Smith for his commentary. 
Post #2802
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 Posted 6/15/2011 11:58:02 AM
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out there (6/14/2011)
Hi Albedo,

You mentioned about how high doses of folic acid and selenium promoted tumor growth.  What would be considered a high dose of selenium?  My wife is currently taking 200mg a day of selenium and has had breast and colon cancer in the past so is this a concern?

Thanks,

Out There

Hi Out There. I do recollect concerns for folic and benfotiamine (in this thread) but not for selenium. Please search on the web and talk to your doctor and/or oncologist. There is lot of information on preventive effects of selenium (and would not exceed 200 mg), this study abstract points to benefits against angiogenesis so supplementation might be good choice.
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 Posted 6/16/2011 6:43:19 AM
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Albedo,

Thanks so much for getting back to me so fast.

Out There
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 Posted 6/16/2011 8:01:09 AM
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albedo (2/14/2011)
Hoping for some critics I just wish to let you know I cut by 4 the carnosine recommended dose in LEF formula (1000 mg). I understand that according to LEF a dose less than 1000 mg might be ineffective but I do not wish to take risks with large doses of benfotiamine.

Any critics on this?


Hello albedo, I will present my thoughts on all this: Moderation in all things is best in most cases [ not all cases for everyone at all times], including any and all supplements, exercise and such. Too much of anything is generally BAD for anyone. Our species, people, evolved in an environment that did not include excessive amounts of any particular nutrient.
    Never the less: I do see life enhancing value in supplements. But what is the ideal dosage for all the different people ? Hopefully, in this forum, we can find some guidance about all this amongst each other.
   Also, importantly: the knowledge base has grown exponentially in the last 50 years or so about all this and many new and important discoveries have been made and investigated. It is an ongoing process with many questions left unanswered and new ones appearing, arising constantly.
   The goal is life extension and enhancement. We wish to live a long time with a youthful physical body. Eternal Youth the ultimate goal.
   Some risks including cancer are associated with excessive amounts of some supplements. There is a growing body of evidence that BHT [ butylated hydroxytoluene ] taken in small dosages [ 100mg to 400mg ] per day REDUCES the risk to many cancers in a very many mice studies beginning with Dr. Denham Harman`s back in the 1950s and 1960s.
   I also only very recently ran across some important discoveries being look into by some Canadians and others about a compound with very promising results as a treatment for many cancers and maybe all cancers. I will dig up a link to all that now and post it here:  http://www.escapistmagazine.com/forums/read/18.283841-Canadian-Scientists-Cure-Cancer-No-One-Notices
  How can the importance of this discovery be overstated ? Yet, it remains IGNORED, by conventional medicine and the alternatives community. You hear, read very little about it. How can this be ? That article answers that question very well. Please do read it.   ...syntax
Post #2815
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 Posted 6/18/2011 1:50:00 AM
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Hello Syntax, thank you for the time you took to put together your thoughts on this which I appreciate.
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 Posted 6/18/2011 12:16:19 PM
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I've found a abstract report here http://www.nature.com/cdd/journal/v17/n4/full/cdd2009149a.html 
which states AGES/RAGE may be a cause of tumors in the first place because they sustain autophagy and limits apoptosis.

So Benfotiamine may be good because it inhibits AGE/RAGE, but on the other hand there is this thiamin tumor study. Which state Benfotiamine may promote tumor development by shuttling glucose through the pentose pathway.

So now I'm even more confused, but have decided to supplement with LEF's recommendation of 400-500mg daily.

It would be great if Dr. Smith or somebody with obviously more brains than me gave their opinion in the matter.


Post #2837
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 Posted 8/24/2011 12:16:27 PM
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hello triplecrown/advocate!
please... do you have any more info on the thiamine tumor study you mentioned in post 2837?
thanks,
robertc2
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 Posted 9/1/2011 10:57:06 AM
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Hey Robert ,
This is what I was referring to in post 2837. Sorry it took me a while to get back to you Smile
http://www.benfotiamine.org/excessthiamine.htm
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 Posted 10/7/2011 11:16:49 AM
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Good or bad? This is definitely on the good side:

"Powerful beneficial effects of benfotiamine on cognitive impairment and β-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice"


http://brain.oxfordjournals.org/content/133/5/1342.long

What I found particularly interesting (but did not read the fully study, sorry) is the apparently uniqueness of benfotiamine vs all other thiamine derivatives.


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 Posted 12/28/2011 4:08:36 AM
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What I find strange in the following study, when comparing with the link posted above (post#3878) is that, while clearly confirrming better absorption than thiamine, benfotiamine apparently shows no increase of thiamine in the brain

"Our results show that oral administration of benfotiamine leads to significant increases in thiamine, ThMP and ThDP levels in blood, liver but not in the brain. This difference is in agreement with the known pharmacological profile of benfotiamine, i.e. the beneficial effects of the drug concern peripheral tissues but not the central nervous system. Like disulfide derivatives, benfotiamine may be useful for the treatment of acute peripheral syndromes of thiamine deficiency because it is better absorbed than thiamine, but in contrast to sulbutiamine, it seems to be devoid of specific effects on brain function."

http://www.biomedcentral.com/1471-2210/8/10


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