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A new NAD+ supplement from LEF ? ( hopefully )

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 Posted 3/1/2014 9:57:53 AM
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There is a lot of buzz recently in anti aging forums surrounding a new study from David Sinclair of resveratrol fame 
http://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13
Niacinimide Riboside ( Niagen ) has been shown to come close to what Sinclair used to boost NAD, more so than regular niacin.    There is evidence that CD38 reduces NAD+ and inhibiting it with flavonoids like C3G, apigenin etc is synergistic.
We show that pharmacological inhibition of CD38 results in higher intracellular NAD+ levels, Finally, apigenin administration to obese mice increases NAD+ levels"
http://diabetes.diabetesjournals.org/content/62/4/1084.short

I think that a supplement combining the two would be important for LEF to consider.  I am already supplementing this on my own with what is available.   The problem with flavonoids for CD38 inhibition is bioavailability ....this is where LEF's expertise could come into play
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 Posted 3/6/2014 7:49:31 AM
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hi Kevn:

Your suggestion has been forwarded to Life Extension's Product Development Department.

D Dye
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 Posted 3/6/2014 7:59:40 AM
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Interesting suggestion, indeed Smile
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 Posted 3/6/2014 8:34:44 AM
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The use of the flavonoids is interesting for the support of NAD. The use of Niagen is over rated. I bought a couple of bottles of this product early on and have since discovered that it is only twice as potent as niacinamide as far as increased NAD. The Niagen is expensive and the capsules are only 100 mg in their max dosage cap. However, nacinamide is much more effective than niacin in obtaining higher NAD levels. 

The discovery itself is a further update and some clarification of old news for the use of niacinamide with resveratrol. Go to Life Enhancements site type in Krebs cycle or niacinamide and see that they have been recommending the use of niacinamide since the early MIT studies years ago. 
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 Posted 3/7/2014 2:12:34 PM
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"However, nacinamide is much more effective than niacin"


Somebody correct me if I'm wrong here, but isn't there some independent benefit of the "niacin flush" you can only get from niacin?

I long ago read some health guru make the pitch about how the niacin flush  will clean your arteries and otherwise does all sorts of amazing things for your cardiovascular system that cannot come from niacinamide.

I make a point to subjecting myself to an intense, red, all body flush with a treatment of about 750 mg of quick-release niacin taken once per month (in addition to daily, regular supplementation).


Anyone care to advise me further/otherwise?

Thanks!



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 Posted 3/7/2014 4:18:02 PM
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Fastingly,

The niacin flush is part of the circulatory system benefit of niacin, which can favorably impact lipids, despite a recent study that concluded that it had no protective effect (and it may not have one in some people).  The histamine-releasing effect of niacin has other benefits.  Niacinamide and niacin also may have longevity benefits, yet niacinamide's effect in this area has been argued both ways.

D Dye


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 Posted 3/7/2014 6:46:15 PM
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Sounds good but its a three things you should be taking maybe four with niacin 
Q10 blend with Omega-33333 
Resveratrol
DHEA 
Good multi -calcium good amount of Vit D

http://ca.linkedin.com/pub/norm-lawlor/47/85/5bb
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 Posted 3/8/2014 8:18:18 AM
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Nicotinamide riboside is different from Niacinimide or niacin, and is a more direct NAD+ activator.   It's mechanism of action has nothing to do with the flushing effect that niacin users want to increase HDL.
It's the closest one can get to the molecule used in the Sinclair study.
 In eukaryotes, nicotinamide riboside is a newly discovered NAD+ precursor that is converted to nicotinamide mononucleotide by specific nicotinamide riboside kinases, Nrk1 and Nrk2. In this study, we discovered that exogenous nicotinamide riboside promotes Sir2-dependent repression of recombination, improves gene silencing, and extends lifespan without calorie restriction. "
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 Posted 3/9/2014 12:27:11 PM
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Just so readers don't get confused nicotinamide and niacinamide are two different terms used interchangeably to describe the same thing. Nicotinamde riboside is a form of B3 found in milk and beer that is effective in increasing NAD. Niagen is the commercially available product for nicotinamide riboside.

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 Posted 3/15/2014 7:53:26 AM
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Two well known scientist in this area (working in my Country) are Johan Auwerx and Carles Cantó and Nestlé is behind.

"...We show that NR supplementation in mammalian cells and mouse tissues increases NAD+ levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities. Consequently, our results indicate that the natural vitamin NR could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function..."

https://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900192-1

I would definitively try NR if LEF makes it to their standards.

Today you can find other sources, e.g. in EU: http://www.supersmart.com/en--Anti-aging--Nicotinamide-Riboside-125-mg--0632


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