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A new NAD+ supplement from LEF ? ( hopefully )

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alc
 Posted 4/15/2014 6:10:48 PM
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After I red about the study that prof. Sinclair did and published in December, I googled for NAD+

I found out that Biotivia is developing a product that they claim is doing the same thing, like the study did.

http://www.biotivia.com/

You might read on their web site about  MitoTrans* (NAD+)

http://www.biotivia.com/nad_plus_mitotrans_antiaging.html

I'm interested in reading others comments/thoughts about this product that Biotivia is producing.

Adrian
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 Posted 4/16/2014 11:00:36 AM
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alc (4/15/2014)
After I red about the study that prof. Sinclair did and published in December, I googled for NAD+

I found out that Biotivia is developing a product that they claim is doing the same thing, like the study did.

http://www.biotivia.com/

You might read on their web site about  MitoTrans* (NAD+)

http://www.biotivia.com/nad_plus_mitotrans_antiaging.html

I'm interested in reading others comments/thoughts about this product that Biotivia is producing.
Adrian


Interesting. I have read somewhere that NAD itself is too large of a molecule to be absorbed.  Perhaps their delivery system gets around that.  There isn't any reliable data regarding NAD enhancement in humans with any specific product or dosage of products.   According to Guerante and Sinclair, NR being a small molecule is the best and most direct precursor of NAD
This is another reason that it would be interesting to see how LEF addresses this, and which molecule they will choose to use.  The problem with anything other than plain old niacin, is patent issues. 
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 Posted 4/25/2014 3:19:04 AM
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DDye (4/14/2014)
Albedo,

Product Development provided the following response:

We greatly appreciate the feedback and are continuously scouring emerging research for synergistic and novel ingredients. However, we do not disclose information regarding our plans for future product development. 


OK thank you for the feedback.


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Post #12726
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 Posted 5/13/2014 7:03:20 AM
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albedo (3/29/2014)
There is a presentation from Guarente. If time I might try and go to understand better. Any question I can ask?
http://sv.epfl.ch/life-science-seminar

Date

May 9 

Time

11:00

Speaker

Leonard Guarente 

From

MIT, Laboratory for the Science of Aging and Koch Institute, Cambridge, USA 

Title

SIRTUINS, NAD and AGING 

Location

SV 1717a 

Host

Johan Auwerx 

Student lunch

Students : sign up for lunch 


Unfortunately the meeting was cancelled as per the following link:
http://memento.epfl.ch/event/sirtuins-nad-and-aging/
However, at the bottom of the link, following the abstract, you have a good link to a recent review work: "Calorie Restriction and Sirtuins Revisited". The paper replies to some of the recent challenges on the reported effect of sirtuins mediating CR hence extending longevity. Note at the very end: "Finally, supplementation with the NAD precursorsNMNor nicotinamide riboside has been shown to counteract aging (Ramsey et al. 2008; Mouchiroud et al. 2013) and may offer another strategy of keying sirtuin surveillance to forestall aging and diseases."


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Post #12816
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 Posted 5/18/2014 9:25:50 PM
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Niagen is NR cholride and not NR. I suspec the chloride form has bioactive differences than NR. NR is very expensive. NR chloride is much less expensive.
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 Posted 7/9/2014 5:40:21 AM
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In light of this information on the importance of NAD, would anyone advise if one should continue taking an NADH supplement? It sounds like this pseudohypoxia cell-aging occurs with imbalanced NADH at the mitochondrial cell level, so is taking a dietary supplement of NADH therefore somewhat counterproductive to the goals of life extension?


___________________________________________________________________________________________________


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 Posted 10/13/2014 6:05:12 PM
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Hi,

  Very interesting stuff. It would be reassuring to see info regarding safety and known side effects.
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 Posted 10/21/2014 4:57:42 PM
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I was just reading about it after seeing the new supplement and wondered if this reference has any relevance to NR?

http://www.ncbi.nlm....les/PMC3318212/

"Depletion of available methyl groups, whether from a poor diet or one with excessive nicotinamide, may be a common cause of epigenetic phenomena given the marked influence methylation has on gene expression in pluripotent and differentiated cells that maintain cellular identity [265]. The methylome is an important mediator of information and modifies gene transcription and translation including riboswitches affecting RNA metabolism and in toxicology pathways in concert with NAD and ATP and all appears to be involved in a number of diseases seen within the pellagra phenotype such as cancer and motor neurone disease [267272]. A major role for the methylome is well accepted for many cancers and their related epimutations sometimes working in concert with DNA sequence mutations in tumour suppressor and DNA repair genes and may well be modifiable by diet [273277]. There may be several mechanisms whereby such metabolic programming can be inherited and affect offspring [278]."


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 Posted 10/23/2014 11:38:14 AM
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LEF has started now to carry NIAGEN® Nicotinamide Riboside, here. I wonder how you considerer their new product and its price (to me it does not look a bad deal). I understand some of you (e.g. Kevnzworld) are already using NR. Which dosage?
Post #14044
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 Posted 10/23/2014 12:00:06 PM
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albedo (10/23/2014)
LEF has started now to carry NIAGEN® Nicotinamide Riboside, here. I wonder how you considerer their new product and its price (to me it does not look a bad deal). I understand some of you (e.g. Kevnzworld) are already using NR. Which dosage?


In the meantime I got some answers (e.g. on pricing) here:
http://www.longecity.org/forum/topic/73837-nicotinamide-riboside-nrniagen-vendor-vetting-and-discussion/?view=findpost&p=692457
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