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Two per day multivitamin update

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 Posted 11/5/2013 4:57:08 AM
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Hi!

I just learned about the new changes that LEF has done on its multivitamin "Two per day".
Glad to see that mixed tocopherols and the active forms of vit. B2 and B6 have been added! Well done.

I'd be interested in knowing how many mg of riboflavin 5’-phosphate and pyridoxal 5’-phosphate does the multivitamin contain?

LEF has also changed a little bit the composition of zinc ( now it's zinc citrate + OptiZinc® zinc monomethionine) without modifying the total amount which is still 30mg.
Is there any particular reason behind this choice (adding zinc citrate)? 


Suggestions for next improvements:

- change the manganese form from gluconate to amino acid chelated forms, which have a better bioavailibity
- change the magnesium form. Magnesium oxide has in fact a poor bioavaibility that greatly influence its effectiveness in the body( the oxide form is supposed to absorb about 30%) Magnesium aspartate, lactate, citrate and glycinate each have bioavailability four times greater than the oxide.
I can imagine that the reason that led LEF to this choice was due to the high elemental content of magnesium and ease-of-use in manifacturing. However personally I'd prefer having even lower dosages of magnesium in the "Two per Day" but in a form that the body can better use.

Thanks

Alessandro


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 Posted 11/6/2013 3:45:44 AM
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I'm glad to see that active B-vitamins as well as a little bit of mixed tocopherols have been added! That's a considerable improvement (although I would have hoped for more than just 20mg of mixed tocopherols). I also like the fact that cholecalciferol has finally been substituted for ergocalciferol, as it is the more physiological form of vitamin D.

The only remaining drawback, however, is that the beta-carotene still seems to be the synthetic form. It really should be replaced with the natural form (e.g. Betatene), like in the mix. Maybe next time?

I also noticed that the amount of lipoic acid has been reduced from 125mg to 25mg, which is a pity, because it went down from a (probably) useful amount to "just another ingredient on the label". Is there any particular reason behind this decision other than cost?


Magnesium oxide has in fact a poor bioavaibility that greatly influence its effectiveness in the body( the oxide form is supposed to absorb about 30%) Magnesium aspartate, lactate, citrate and glycinate each have bioavailability four times greater than the oxide.

I'm affraid that is wrong. There are many such claims (mostly by sellers of fancy, expensive magnesium formulas) and all of them are either made up or rely on methodologically unsound studies.  There are in fact hardly any differences in the bioavailability of different forms of magnesium. Cheap mag oxide is just fine. See: http://translate.google.com/translate?langpair=de|en&u=http://www.pharmazeutische-zeitung.de/index.php?id=29065
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 Posted 11/6/2013 10:16:35 AM
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Welcome to the Forums, Alernd.

There are 10 mg riboflavin 5'-phsophate and 10 mg pyridoxal 5'-phosphate per serving.  Zinc citrate was added to the zinc provision because of its ability to be well absorbed.

The amount of lipoic acid was reduced to allow for additional ingredients.  Two-Per-Day's 4,500 IU beta-carotene is 99% synthetic beta-carotene and 1% natural beta-carotene.

Your suggestions and Timar's have been reviewed by Product Development. 

There are a few studies that show that other forms of magnesium than the oxide are better absorbed.  Because some of these forms have low elemental amounts of the mineral, which take up more space, not sure if their arguably better absorption is worth their inclusion on a volumetric basis.   

D Dye
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 Posted 11/8/2013 2:07:58 AM
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Thank you both for the answers!

Greetings
Alessandro

ps: definetly support  Timar 's request for replacing, when possibile, the synthetic form of betacarotene with the natural one.
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 Posted 11/21/2013 10:20:17 AM
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  Regarding the changes to Two-Per-Day Capsules - I definately prefer the previous level of 125 mg of Alpha Lipoic Acid, instead of 25 mg.  Also 30 mg PABA was removed in the new formulation.  Is there a reason for the removal of PABA, other than just making room for other ingrediants?

  I'm guessing that extra Alpha Lipoic Acid might fit in the capsules.  But, Life Extension probably wanted to standardize on the same formula for Two-Per-Day Capsules and Tablets.  (Although previously the formula differed with Capsules using Vitamin D3 while Tablets used Vitamin D2.)
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 Posted 11/21/2013 11:20:35 AM
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PABA was removed to make room for the natural mixed tocopherols.

D Dye
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 Posted 11/22/2013 8:47:05 AM
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I think it is hard to criticise changes to the formulation if you don't know the exact economics regarding cost and space (dried mixed tocopherols may be rather bulky and/or expensive). I'm currently formulating my own phyto blend so I know about the tradeoffs one has to make.

One suggestion I would have is to decrease the amount of B1 and/or B6 from 75mg to 50mg, which would be still plenty and to cut out the 25mg potassium citrate to make up space for more mixed tocopherols and lipoic acid.

If cost is the issue, I have to say that personally I would happily pay a few euros more per bottle for getting the best possible Two-per-Day formulation. With the Mix there seems to be a clear priority of quality over price. With the Two-per-Day I have the impression that price seems to be more of a priority (otherwise there would be no reason to use synthetic beta carotene for example). However, I think many poeple (like be) buy the Two-per-Day not primarily because of the low price but because they want to have the best available "basic" multivitamin formula, which is convenient to take and can be combined with other customized supplements. So maybe it would be a good idea to formulate the Two-per-Day with the same quality-over-price priority as the Mix.
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 Posted 10/30/2014 5:53:03 AM
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Hi DDye,

what is the purpose for adding a very small quantity of NIAGEN (Nicotinamide Riboside) in Two per day's new formulation? 

Thanks
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 Posted 10/30/2014 6:23:19 AM
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Nicotinamide riboside has been shown in studies to support mitochondrial health and promote pathways of longevity.

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 Posted 10/30/2014 12:43:42 PM
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At just 1 mg the amount is so small it seems that it was just added to say it's there. That amount wouldn't be significant.
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